NFC West Players You Must Draft For Fantasy Football in 2021

NFC West Fantasy Football Background

Who are the NFC West players you must draft for fantasy football in 2021?

Today’s post will cover players from all 4 NFC West teams that will improve your fantasy football team whether you play on a weekly or annual basis. You’ll probably find a few names you did not see coming today, too, so we’re looking at more than just the obvious studs from each team. Brace yourself for a few sleepers and even some ultimate boom-or-bust selections.

Are you ready to discover a few more players to add to your queue?

Arizona Cardinals

Kyler Murray is the obvious stud for the Arizona Cardinals, and he may be the most coveted player in the NFC West for fantasy football. Murray improved in every facet of the game in 2020 and, if it weren’t for a late-season injury, would have eclipsed the 4,000-yard passing mark.

Murray totaled 37 touchdowns and nearly 5,000 all-purpose yards. Now that he has even more weapons in the receiving units, what will Year 3 look like? Expect Murray to eclipse Lamar Jackson and Patrick Mahomes as the league’s best fantasy option at quarterback.

DeAndre Hopkins logged 115 receptions in 2020 with 1,407 yards and 6 touchdowns. If the Cardinals did not stagnate later in the season, Hopkins probably would have surpassed 125 receptions and 1,500 receiving yards. Like Murray, he’s one of the most coveted options at receiver.

Rondale Moore is injury prone, so he may drive you away in the later rounds. However, Moore, when healthy, was one of the most productive players at the collegiate level, logging 35 receptions in just 3 games. He’s basically Wes Welker with speed.

And it makes him a potentially dangerous player.

Chase Edmonds looked good when they called his number in 2019 and 2020 after a subpar rookie season. As the team’s new RB1 who can run and catch, he will hold some hefty value in PPR leagues. But when given a breather every now and again, he’s also a productive runner.

He’s an RB2 in fantasy football.

James Conner came over from the Pittsburgh Steelers. Like Moore, he’s productive when healthy. His injury prone reputation may drive you away, but given his size and credentials, he could resurge into an outstanding option.

Christian Kirk has been on and off the fantasy football radar.

But he’ll reward owners from time to time. Now that A.J. Green and Rondale Moore are in town, it will open up even more options for Kirk to succeed and reward fantasy owners for taking a chance on him.

Los Angeles Rams

Matthew Stafford has had seasons where he was a dynamic QB1 for the Detroit Lions. Now in Los Angeles, Stafford has more potential than ever before with the chances he will get down there along with his supporting cast on offense. He will be a QB1 in deeper leagues with over 12 owners.

Cam Akers won’t be drafted in most leagues because of his Achilles injury. However, he’s a good option if you play in a Keeper League or a Dynasty League. Given his performances in 2019 and his steady improvement, he’s more than worth taking a flyer on.

Darrell Henderson will probably step in as the RB1 in Akers’ absence. Henderson rushed for 624 yards in 2020 for 4.5 yards per carry, and he also tacked on 5 rushing touchdowns. He could be in for a breakout season since Akers won’t be able to suit up, so don’t be surprised if he’s an eventual RB1.

Kupp recorded 92 receptions, so he’s more than valuable in PPR leagues. While he didn’t impress in yards (974) or touchdowns (3), his sure handedness will make you take a flyer on him in the early rounds of your fantasy draft.

Robert Woods also recorded 90-plus receptions.

Like Kupp, he lacked in receiving yardage with 936 yards. However, he scored 6 touchdowns and is more valuable if you play in a PPR league. Woods is also one of those players who has become more productive since he arrived in Los Angeles.

Tyler Higbee disappointed fantasy owners in 2020 with just 44 receptions and 5 touchdowns.

However, he’s a sure-handed target who will be a threat in the red zone with Matthew Stafford at quarterback. He may not be a TE1 in most fantasy leagues. But he’s a viable TE2 who can morph into a TE1.

And remember:
Higbee won’t be in a timeshare this season with Gerald Everett, who logged respectable numbers and took a few receptions from Higbee in 2020.

San Francisco 49ers

Trey Lance is the obvious choice if you’re playing in a Keeper or Dynasty League. He will see the field in specific packages and you can make a bet that he will get a full look in 2022. If he’s there toward the final rounds in your Keeper League, take him. He’s also worth spending an early-round pick on in Dynasty Leagues.

Jimmy Garoppolo:
He isn’t the hottest quarterback on the fantasy football market. However, he is a decent option for a QB2 in deep leagues. And even in more shallow leagues, he’s worth taking a flyer on if you wait until the late rounds to take a QB2. The 49ers are clear that he will be their quarterback in 2021.

Raheem Mostert may be the most underrated player in both reality and fantasy football. If Mostert didn’t struggle with injuries in 2020, he’d probably be a top-rated running back in fantasy football. However, given his injuries and number of backs on the depth chart, he’s a clear handcuff.

Trey Sermon is the back you need to handcuff Mostert with. Sure, Jeff Wilson is a good option too, but Sermon’s draft status will probably supersede Wilson, who has only had one good stretch in a single season. If push comes to shove, draft Sermon.

He will see playing time.

George Kittle remains one of the league’s most productive tight ends. Some of us don’t value tight ends as much as we do running backs. Others do. If you’re in the latter, Kittle is your guy if the top performers like Travis Kelce and Darren Waller are gone.

Brandon Aiyuk burst onto the scene and has logged 60 receptions for 748 yards and 5 touchdowns.

Aiyuk only played in 12 games, so imagine what he can do when he’s healthy for an entire season. He could easily make The Leap and develop into a high-end WR2 or even a WR1.

Deebo Samuel is worth taking a flyer on. Given his injuries, he may scare you away. However, he logged 33 receptions for 391 yards in just 7 games. He’s more than worth taking a look.

Seattle Seahawks

Russell Wilson looked like the MVP in both the NFL and in fantasy football. Even at 33, he’s still going strong, and he will once again serve the role as QB1 to any team that drafts him. Look for Wilson to have a repeat season. And if they “let Russ cook,” then there is no stopping him. Draft him.

DK Metcalf is literally something from another species.
The 230-lb Calvin Johnson clone logged 83 receptions, 1,303 yards, and 10 touchdowns. He’s, at worst, a third-round pick, and you’d do well to draft him sooner. Especially now that we know just how fast he is these days.

Chris Carson is injury prone, and you may shy away from him for that reason. However, there’s no denying that when healthy, he’s one of the league’s best players. He logged 5 touchdowns, 681 rushing yards, and 4.8 yards per carry in 2020.

Tyler Lockett is the only player keeping teammate DK Metcalf from becoming one of the league’s top receivers. Lockett is especially valuable in PPR, given his 100-reception season, 1,054 receiving yards, and 10 touchdowns. He’s a clear-cut WR1.

Gerald Everett comes over from the Los Angeles Rams.
As a TE2 in LA, he recorded 41 receptions, 417 yards, and 1 touchdown. What will he do as a TE1? He’s one of those players you won’t pick early, but he’s a smart pickup late in the draft. Because with Wilson at quarterback, Everett will score often.

Rashaad Penny is the deep sleeper. They say he’s a bust, and maybe he has been to this point. But besides last season’s injury-riddled debacle, Penny has played well in limited action and when healthy. He’s one of those guys worth considering for the last pick of your draft. The deep sleeper pick.


The NFC West has a few highly sought-after players all over the place in fantasy football. Not just that, they’re also said to be the NFL’s toughest and most competitive division.

After reading this post, you can conclude that they are competitive in more ways than one. Do yourself a favor and draft some of these valuable players to improve your fantasy football team at online sportsbooks or against your friends.

Who are your favorite fantasy football players from the NFC West? Which of the above players would you build your team around? Let us know in the comments.

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Rex Hoffman / Author

Rex Hoffman is a passionate sports writer, with over five years of experience covering sports journalism in line with the Vegas betting landscape. His favorite subjects include football, basketball, and baseball. As a Las Vegas resident, he enjoys finding an edge against the local sportsbooks and aims to share his extensive knowledge with both beginners and experienced bettors. Rex also dabbles in horse racing wagering and enjoys typical casino fare like blackjack and poker in his spare time.

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