USC Trojans vs. Kansas Jayhawks Pick – NCAA Tournament March 22, 2021

We have eight more games scheduled on Monday in the Round of 32 of the NCAA Tournament. The Oral Roberts Golden Eagles are the darling of the tournament, as the No. 15 seed pulled off another upset on Sunday. This time a 81-78 win over the Florida Gators. Oral Roberts is off to the Sweet Sixteen and playing with house money now. No matter what happens from here on out, Oral Roberts’ season has been a major success.

Are we going to see more wins from the dogs on Monday? We will likely see a couple more underdogs win straight up on Monday. The USC Trojans are a 1-point favorite, so we aren’t going to see an upset here one way or another despite what the seeding indicates. The biggest upset on the board would be the Oklahoma Sooners beating the Gonzaga Bulldogs. For the Sooners to win, they’ll have to end a perfect season for Gonzaga as a 14-point underdog.

No. 6 USC are small favorites over No. 3 Kansas in the latest game on Monday night. USC and Kansas will close out the Round of 32. Following this contest, the Sweet Sixteen is officially set for next weekend. That’s if no team contracts Covid-19. Knock on wood. Hopefully nobody has to, but that would force a team to drop out of the Sweet Sixteen, granting their opponent an automatic ticket to the Elite Eight. USC is coming off a 72-56 win over the play-in Drake Bulldogs.

Drake beat Wichita State by a point in the First Four, 53-52, but they were overwhelmed against USC on Saturday. When they went to a big lineup against Drake, the Bulldogs had no answers around the rim. The Trojans were able to respond after a 72-70 loss against the Colorado Buffaloes. Colorado led by McKinley Wright is a good team, so no shame in losing against the Buffaloes. The Jayhawks are feeling confident in their chances coming off four straight wins and a 93-84 win over Eastern Washington in the First Round. Head below for our free USC vs. Kansas pick on March 22, 2021.

Southern California Trojans (No. 6) vs. Kansas Jayhawks (No. 3) NCAA Tournament Betting Odds:


  • USC -1 ( -110)
  • Kansas +1 (-110)

  • Kansas OFF

  • Over 134.5 (-110)
  • Under 134.5 (-110)


USC vs. Kansas Prediction:

USC has to go to their size against the Jayhawks tonight. It paid off nicely against Drake, and while the Trojans are going to face a lot more resistance against Kansas, they still own a size advantage in this matchup. Kansas is going to have to hit their jumpers and the deep ball if they’re going to get by USC in this one. If their shots fall, they’re going to be moving on to the Sweet Sixteen. However, Kansas has been incredibly inconsistent from the field.

They are shooting 43.9% from the field for 186th in the NCAA. Kansas is averaging 73.3 points per game. In their previous five games, they’ve netted slightly more with 74.4 points. Before throttling Eastern Washington for 93 points, the Jayhawks scored 67 in a 67-62 win over a bad UTEP team, and 69 points in a 69-62 win over Oklahoma, then dropping out of the Big 12 Tournament because of Covid-19.

Relying on their jumper isn’t the best formula for success, but against a big USC lineup, they’re likely going to have to hope they get hot from outside. USC is 62nd in the NCAA with a field goal percentage of 46.5%. They’ve scored an average of 74.3 points per game, and conceding 64.1 points per game. The Trojans were incredibly efficient and underrated defensively. Teams have shot just 39.1% from the field against USC. That’s good for 11th in the NCAA.

The Pac-12 gets ripped for being the worst power conference in the NCAA, but the conference has been representing well this year in March. USC has been a sharp bet in March in recent memory. They’ve gone 5-0 ATS in their last five NCAA Tournament games. It might be an upset because of a No. 6 beating a No. 3 seed, but beyond that, it’s not a traditional betting upset. Jalen Wilson is expected to play for Kansas, but will not be close to 100%, as per Bill Self. Expect size to win out, as USC edges out Kansas by a score of 68-63 to get another Pac-12 team into the Sweet Sixteen.


Our Bet
Kyle E / Author

Kyle is a veteran of TheSportsGeek and has spent nearly a decade providing accurate sports picks and writeups here. He has been a sports handicapper for 10+ years and started sharing his picks and thoughts in 2011 at TheSportsGeek. His expertise spans across multiple sports, including the NFL, NCAAF, MLB, NHL, and horse racing. Prior to writing for TheSportsGeek, Kyle was a fantasy football expert, who ultimately parlayed it into a successful sports betting career. You can find his picks daily only at TheSportsGeek.