Virginia Tech Hokies vs. Duke Blue Devils Pick – NCAAB December 22, 2021

The Virginia Tech Hokies and Duke Blue Devils headline the Wednesday card on the college hardwood. Duke is going into tonight with just one blemish on their resume.

They are in excellent standing at 10-1, with a loss at Ohio State on November 30 their only loss. The Blue Devils responded with three wins in a row in blowouts following that loss.

Duke made it look easy, most recently an 87-56 win over the Elon Phoenix on Saturday. This came after a textbook 96-67 win over Appalachian State.

This season, their biggest win was an 84-81 win over the Gonzaga Bulldogs in Las Vegas on November 26. The Blue Devils look like a national contender, and voters agree as they’re ranked No. 2 in the NCAA.

The only team higher than Duke is the defending champion Baylor Bears. Baylor is easy, and Duke has to be the easy second choice. There isn’t any controversy here.

The distance between Duke and Baylor to Purdue at No. 3 is pretty considerable. I’m not overly high on Purdue yet; they may not even be the best team in the Big Ten.

ACC foe, Virginia Tech, has gotten off to a solid start this season. They’re not going to scare off top contenders, but Duke could be in for a fight tonight if the Blue Devils take them lightly.

The Hokies head to Duke with an 8-4 record, with some ups and downs thus far. They are coming off a 86-49 win over St. Bonaventure after losing on the road at Dayton as 2.5-point favorites, 62-57.

Four of Virginia Tech’s losses have come in their last six attempts. Memphis, Xavier, Wake Forest, and Dayton all handled the Hokies. Is Duke up next over the Hokies? Head below for our free Virginia Tech vs. Duke pick on December 22, 2021.

Virginia Tech Hokies vs. Duke Blue Devils Betting Odds and Team Statistics:

The following odds are courtesy of BetUS:

Teams Spread Moneyline Total
Virginia Tech Hokies +9 (-110) +360 Over 138.5 (-110)
Duke Blue Devils -9 (-110) -440 Under 138.5 (-110)
Team Data Virginia Tech Hokies Duke Blue Devils
Overall Record 8-4 10-11
ATS Record 8-4-0 6-3-2
Away/Home Record 2-1 8-0
ATS Away/Home 2-1-0 4-2-2
Points Per Game 71.6 86.1
Points Against Per Game 56.5 64.4
Field Goal % 46.2 49.1
Three Point % 40.0 37.0

Virginia Tech vs. Duke Prediction:

Virginia Tech will have to put their best effort forth on Wednesday night. They’ve come and gone this season, with one night a good effort and then a bad effort.

This is their toughest assignment yet, and for the Hokies to keep this one close for a potential upset, they need their best form at Cameron Indoor Stadium.

The Hokies go into tonight with 71.6 points per game for 190th in the NCAA. They can shoot from the perimeter but can’t do much else.

If Virginia Tech is going to challenge in the paint, then this will not go well. Virginia Tech lives and dies by the three.

When Virginia Tech isn’t hitting from outside, that’s how they get behind in a hurry. The Hokies are 11th in the NCAA, with a three-point percentage of 40%.

However, Duke has held their opponents to a 31.8% three-point percentage. Virginia Tech can’t just depend on the three to keep up.

Virginia Tech Hokies vs. Duke Blue Devils Betting Trends:

Virginia Tech

  • 6-13 ATS in their previous 19 games as an underdog
  • 5-12 ATS in their previous 17 games on the road
  • 2-7 ATS in their previous nine games after allowing less than 50 points
  • 4-13 overall in their previous 17 games versus Duke
  • 0-8 overall in their previous eight games versus Duke at Cameron Indoor Stadium


  • 3-0-1 ATS in their previous four games at Cameron Indoor Stadium
  • 4-1-1 ATS in their previous six games
  • 3-1-1 ATS in their previous five games as the betting favorite
  • 3-0-1 ATS in their previous four games a win by more than 20 points
  • 8-0 overall in their previous eight games versus Virginia Tech at Cameron Indoor Stadium

It’s hard to see how Virginia Tech will keep this within double digits. The only way is getting hot from the outside, and they can’t miss.

However, even if Virginia Tech is hot in the first half, I could see Duke making adjustments and stopping them after halftime.

The Blue Devils are fifth-best in the NCAA with 86.1 points per game, so they might have to spray away from three, and hope shots fall. That doesn’t appear like the best game plan, though.

Duke is shooting 49.1% from the field and over 50% at home. Through eight at Cameron Indoor, the Blue Devils have scored 89.8 points per game. The Hokies likely don’t keep pace.

I’m siding with the Blue Devils in a point spread that looks a few points too short. They should record an 84-70 win or thereabout to cover.


Virginia Tech vs. Duke Pick
Kyle E / Author

Kyle is a veteran of TheSportsGeek and has spent nearly a decade providing accurate sports picks and writeups here. He has been a sports handicapper for 10+ years and started sharing his picks and thoughts in 2011 at TheSportsGeek. His expertise spans across multiple sports, including the NFL, NCAAF, MLB, NHL, and horse racing. Prior to writing for TheSportsGeek, Kyle was a fantasy football expert, who ultimately parlayed it into a successful sports betting career. You can find his picks daily only at TheSportsGeek.

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