Arizona Diamondbacks vs. San Diego Padres Pick – MLB June 21, 2022

The Arizona Diamondbacks and San Diego Padres meet again following a 4-1 win for the home team on Monday night. Yu Darvish locked down the D-backs, as he allowed 4 hits and 1 earned run inning across 7 innings.

Conversely, Zach Davies gave up all the runs for Arizona. Davies yielded 4 hits and 4 earned runs through 6 innings of work.

Manny Machado was not active last night, but the Padres have some good news regarding his ankle injury. Machado didn’t go on the injured list, and it appears he won’t have to at all.

That’s a deep sigh of relief for a team that will need Machado in the lineup to compete with the Dodgers in the NL West. The Padres are currently at 42-27 and in a tie with the Dodgers for the lead.

The NL West is on the table for the top-3 clubs. The Dodgers look good, but they’re not great. They have holes that can be exploited in 2022. Their usually scary rotation isn’t so much this season.

San Diego was supposed to duel with the Dodgers last year. That didn’t happen, as the Giants took their spot and ultimately won the NL West. The Giants can get involved again this season as well.

The Diamondbacks are improving, but still two or three years away.

Arizona is going into this one with a record of 32-37 and 10 games behind the Dodgers in the NL West. If you recall the long losing stretch they went on last year, this is a big improvement from 52-110 in 2021.

The D-backs beat the Twins in two of three games before the loss last night. They were coming off a 7-1 win on Sunday afternoon.

The Diamondbacks are looking to send Zac Gallen to the bump. Gallen can be tough to beat, but hasn’t been at his best as of late. Sean Manaea counters for the Padres.

Head below for our free Diamondbacks vs. Padres prediction on June 21, 2022.

Arizona Diamondbacks vs. San Diego Padres Live Betting Odds:

The following odds are courtesy of Bovada:
Teams Spread Moneyline Total
Arizona Diamondbacks +1.5 (-195) +115 Over 6.5 (-115)
San Diego Padres -1.5 (+165) -135 Under 6.5 (-105)
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Team Data Arizona Diamondbacks San Diego Padres
Overall Record 32-37 42-27
Away/Home Record 15-18 18-13
Batting Average .215 .240
Batting Average Away/Home .221 .223
Runs Per 9 4.13 4.73
Team ERA 4.24 3.48
Team ERA Away/Home 4.68 3.15

Diamondbacks vs. Padres Prediction:

Zac Gallen was flying through lineups to open this season and in Cy Young form. He’s going into tonight with an ERA of 2.91 and a 0.98 WHIP. That’s rock solid, and if Gallen holds those numbers through September, it wouldn’t be a bad season.

Gallen has been more efficient at home, with a 2.57 ERA and 0.83 WHIP in 42 innings. He’s still good on the road, but a drop to a 3.52 ERA and 1.26 WHIP across 23 frames.

In his previous 16.1 innings on the bump, Gallen posted a 4.91 ERA and 1.23 WHIP.

That’s not very Gallen-line. The Phillies ripped him for 7 hits and 4 earned runs in 1.2 innings two starts back. He looked better in his latest performance, with 2 hits and 2 earned runs conceded in 7 innings.

This Padres roster has had success against Gallen, and it isn’t because of Machado. Machado is hitting just .200 versus Gallen.

The Padres are hitting .260 with 4 home runs and 8 RBIs in 49 at-bats as a team. Gallen is one of the better hurlers in the National League, but he hasn’t escaped the Padres without suffering damage.

San Diego is in the top-10 with 4.71 runs per 9 innings, but the pitching staff has been leading the club to wins.

The Padres are fourth in the majors with 3.77 runs against per 9 innings and a .222 batting average. The bullpen has posted a 3.52 and a 1.11 WHIP.

Arizona Diamondbacks vs. San Diego Padres Betting Trends:


  • Record (Last 10): 4-6
  • 0-5 overall in their previous five second game of a series
  • 5-13 overall in their previous 18 games on a Tuesday
  • 0-4 overall in their previous five games versus the Padres
  • 1-4 overall in their previous five games at San Diego
  • 21-61 overall in their previous 82 games versus the NL West


  • Record (Last 10): 5-5
  • 6-2 overall in their previous eight games after a win
  • 4-1 overall in thier previous five second game of a series
  • 6-1 overall in their previous seven games after conceding 2 or fewer runs
  • 8-3 overall in their previous 11 games versus a right-handed starter
  • 17-5 overall in thier previous 22 games versus a starter with a WHIP less than 1.15

  • Sean Manaea enters Petco Park with an ERA of 3.95 and a 1.15 WHIP. He was in good form in back-to-back starts, allowing 1 run to the Brewers and Mets in big wins.

    He couldn’t tame Wrigley Field, which can be a tough place to pitch defending on the breeze in the outfield.

    Manaea allowed 8 hits, and 5 earned runs to the Cubs last week. Despite that poor start, Manaea has allowed 3 or fewer earned runs in six of his previous eight starts.

    The Diamondbacks have been useless versus Manaea in his career. He has been one of their toughest assignments.

    The D-backs are hitting .065 with just 1 RBI in 43 at-bats. Ketel Marte has two doubles and an RBI in 16 at-bats, but that’s their only offense.

    This isn’t exactly a fade of Gallen, but he does face a worthy challenger in Manaea at Petco tonight. I’m going with the Padres to repeat on Tuesday night.


    Diamondbacks vs. Padres Pick
Kyle E / Author

Kyle is a veteran of TheSportsGeek and has spent nearly a decade providing accurate sports picks and writeups here. He has been a sports handicapper for 10+ years and started sharing his picks and thoughts in 2011 at TheSportsGeek. His expertise spans across multiple sports, including the NFL, NCAAF, MLB, NHL, and horse racing. Prior to writing for TheSportsGeek, Kyle was a fantasy football expert, who ultimately parlayed it into a successful sports betting career. You can find his picks daily only at TheSportsGeek.

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