Arizona Diamondbacks vs. San Francisco Giants Pick – MLB September 28, 2021

The Arizona Diamondbacks find themselves in an important series in the Bay Area right after hosting the LA Dodgers in an equally important series. This has nothing to do with the Diamondbacks, clearly, as they’re going into the final stretch of the season with a record of 50-106. They are 52 games behind the San Francisco Giants for the lead in the NL West. That’s not what’s important.

What’s important is the NL West race between the Dodgers and Giants. The Giants are carrying a two-game lead over the Dodgers going into tonight. As soon as the Dodgers look like they’re going to jump ahead, the Giants block their attempt and keep their lead in-tact. The Dodgers have been the favorites to win the division even while playing behind for most of the season.

The Giants have been of the best value bets to win their division, and you didn’t even have to make the wager before the year started. For a team that wasn’t expected to compete for the divisional title, maybe compete for a wildcard, the Giants to win the NL West was the best bet of the year.

That’s not to say that the Giants are going to win, though. They could collapse in the final weekend, allowing the Dodgers to sweep in and steal the NL West on them. That might be difficult for the Giants to recover in the wildcard if they give this lead up after protecting the lead for months.

The Giants finish off the season with a three-gamer series against the Diamondbacks, and then a three-game tilt versus the Padres. They have to take advantage of these winnable games versus Arizona.

The Padres could give them some problems if they’re interested. The Giants are scheduled to give Logan Webb the starting call, while the D-backs are expected to counter with Luke Weaver. Head below for our free Diamondbacks vs. Giants pick on September 28, 2021.

Arizona Diamondbacks vs. San Francisco Giants Live Odds and Betting History:

The following odds are courtesy of BetOnline:

Teams Spread Moneyline Total
Arizona Diamondbacks +1.5 (+120) +224 Over 8 (+102)
San Francisco Giants -1.5 (-140) -250 Under 9 (-122)
Team Data Arizona Diamondbacks San Francisco Giants
Overall Record 50-106 102-54
Away/Home Record 20-58 49-26
Batting Average .232 .247
Batting Average Away/Home .219 .252
Runs Per 9 4.19 5.07
Team ERA 5.20 3.29
Team ERA Away/Home 5.41 3.37

Diamondbacks vs. Giants Prediction:

The Diamondbacks haven’t had a pleasant season. It included an epic losing streak that saw the Diamondbacks lose 24 straight games on the road. That said, they have nothing to lose at Oracle Park tonight. They won’t be playing with any pressure. However, that’s been the case all season for the Diamondbacks.

The D-backs helped the Giants on Saturday with a 7-2 win over the Dodgers. The Giants have to thank them for that effort. In the series finale on Sunday, the Diamondbacks faltered, 3-0, but the win on Saturday was a big deal in this pennant race. Luke Weaver was dropped by the Dodgers, 8-4, a couple of weeks back.

Weaver has allowed at least 3 earned runs in three straight starts for a 5.17 ERA and a 1.21 WHIP. He’s been a disaster on the road with a 7.94 ERA and 1.59 WHIP in his last 24.1 innings. Put Weaver in the desert at Chase Field and he’s much better off, where he has a 2.31 ERA and 0.90 WHIP across 39 innings.

Arizona Diamondbacks vs. San Francisco Giants Betting Trends:


  • Record (Last 10): 3-7
  • 11-50 overall in their previous 61 games on the road
  • 10-48 overall in their previous 58 games on the road as an underdog
  • 3-13 overall in their previous 16 games after a day off
  • 21-64 overall in their previous 85 games versus a team with a winning record
  • Luke Weaver ERA (Last 3): 5.17


  • Record (Last 10): 7-3
  • 5-1 overall in their previous six games
  • 6-1 overall in their previous seven games on a Tuesday
  • 40-13 overall in their previous 53 games versus a right-handed starter
  • 20-7 overall in their previous 27 games after a day off
  • Logan Webb ERA (Last 3): 5.29

Logan Webb is looking for a bounce back performance at home tonight. He has an ERA of 2.97 and a 1.11 WHIP, but has posted an ERA of 5.29 and a 1.18 WHIP in his previous three attempts.

Webb is back home at Oracle Park, so that should help after getting touched up on the road against the Padres. He conceded 4 hits and 4 earned runs in 4 innings for one of his worst outings in a while. However, Webb has been a much better hurler at Oracle Park.

He is going into Tuesday with an ERA of 1.76 and a 0.95 WHIP across 62 innings in the Bay Area at Oracle Park. Conversely, Webb has recorded a 3.96 ERA and 1.24 WHIP as a visitor on the road. Expect him to pitch in better form in this one following a rough trip to San Diego.

I’m backing the Giants to show up with a nice performance to knock off the Diamondbacks by at least 2 runs. They should have the runline covered in this one.


Diamondbacks vs. Giants Pick
Kyle E / Author

Kyle is a veteran of TheSportsGeek and has spent nearly a decade providing accurate sports picks and writeups here. He has been a sports handicapper for 10+ years and started sharing his picks and thoughts in 2011 at TheSportsGeek. His expertise spans across multiple sports, including the NFL, NCAAF, MLB, NHL, and horse racing. Prior to writing for TheSportsGeek, Kyle was a fantasy football expert, who ultimately parlayed it into a successful sports betting career. You can find his picks daily only at TheSportsGeek.

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