Baltimore Orioles vs. St. Louis Cardinals Pick – MLB May 11, 2022

The Baltimore Orioles and St. Louis Cardinals meet for the second of three games at Busch Stadium on Wednesday night. The Orioles are fresh off an impressive effort in the series opener last night.

Kyle Bradish lasted 7 innings with 4 hits and 2 earned runs allowed. The Cards scored 2 runs in the bottom of the 6th to cut into a 5-0 Baltimore lead, but they couldn’t get any closer than 5-3 in the 9th inning.

The Cardinals are on a three-game skid after taking a split against the San Francisco Giants and opening this series with a loss. They’ve regressed to 16-13 and three games behind the Milwaukee Brewers in the NL Central.

Patrick Naughton went 3.1 innings with 5 hits and 3 earned runs allowed. He didn’t set the bullpen in a good position to win this game, but the bats could have stood to provide more run support.

St. Louis had won five of six games before losing their last three games. It’s been an acceptable start this season for the Cardinals. I’d say it is going as expected in St. Louis at 16-12 going into this evening.

After scoring 3 runs in back-to-back attempts, the Cardinals will look to get the bats going against Spenser Watkins tonight. Watkins is in good form for the O’s going into this one.

The Orioles are off to a respectable start this season with a record of 13-17 and fourth in the AL East. They are 8.5 games behind the New York Yankees for the lead in the division.

There isn’t anything wrong with what they’ve done so far for the O’s expectations. Baltimore is still in a rebuilding phase, which they hope to be out of in the next year or two. They seem to be making small steps forward in 2022.

The Orioles finished with a record of 52-110 last season. Being competitive and should progress would be a success in 2022.

The Cardinals are expected to counter Watkins with Miles Mikolas. Mikolas is on a heater to open this season. He’s been in some of the better form on the mound in the National League.

Head below for our Orioles vs. Cardinals prediction on May 11, 2022.

Baltimore Orioles vs. St. Lous Cardinals Live Betting Odds:

The following odds are courtesy of Bovada:
Teams Spread Moneyline Total
Baltimore Orioles +1.5 (-110) +175 Over 8.5 (+100)
St. Louis Cardinals -1.5 (-110) -215 Under 8.5 (-120)
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Team Data Baltimore Orioles St. Louis Cardinals
Overall Record 13-17 16-13
Away/Home Record 4-10 7-6
Batting Average .233 .236
Batting Average Away/Home .227 .237
Runs Per 9 3.36 4.75
Team ERA 3.59 3.51
Team ERA Away/Home 4.97 3.85

Orioles vs. Cardinals Prediction:

Spenser Watkins is off to a fine start, as he carries an ERA of 3.22 and a 1.39 WHIP going into tonight. He was rolling right along, but is on the heels of his worst performance this season.

Watkins allowed 7 hits and 3 earned runs across 4.2 innings versus the Twins in a 5-3 upset. Despite Watkins struggling to get out of innings quickly, the bullpen stepped up nicely for the Orioles.

He’s been putting opponents on base, which has been a concern going into Wednesday. Watkins has recorded a .371 OBA in his last three starts, so batters are finding a way on the bases.

Eventually, that will catch up to Watkins if he isn’t careful. He posted an ERA of 3.77 and a 1.47 WHIP during that stretch.

Watkins is in his second season in the majors after a 8.07 ERA in 16 games in 2021.

After failing to get into form in his first season in the majors, Watkins can’t get any worse, and he has been much better than his work a year ago. This is his first appearance versus the Cards in his career.

Baltimore Orioles vs. St. Louis Cardinals Betting Trends:


  • Record (Last 10): 7-3
  • 3-7 overall in their previous ten games versus the National League
  • 3-8 overall in their previous 11 games as an underdog
  • 2-10 overall in their previous 12 games versus the NL Central
  • 0-5 overall in their previous five games versus a right-handed starter
  • 18-60 overall in their previous 78 games on the road


  • Record (Last 10): 5-5
  • 4-1 overall in their previous five games as a betting favorite
  • 6-2 overall in their previous eight games at home versus the American League
  • 6-2 overall in their previous eight games on a Wednesday
  • 20-7 overall in their previous 27 games after allowing 5 or more runs
  • 35-16 overall in their previous 51 games as a betting favorite

Miles Mikolas is off to the best start of his career and appears to be back to 2018 form. Mikolas posted a career-high 2.83 through 32 starts that season.

He followed up with a 4.13 ERA the following season, but is getting back to where he was four years ago. Mikolas is going into Wednesday night with a 1.53 ERA and 0.99 WHIP in 36 innings of work.

Mikolas has a solid history against the Orioles and has success versus this current lineup. The Orioles are hitting .199 with a .223 OBP and 2 home runs in 100 at-bats.

In six attempts this season, Mikolas has allowed more than 1 earned run in just two outings. He’s coming off another good performance six days ago against the San Francisco Giants.

Mikolas led the Cards to a 7-1 win over the Giants after a 1-earned run outing through 5.2 innings.

Mikolas has conceded 1 or no earned runs in four of his last five starts following his 2022 debut. He owns a 1.35 ERA and 0.95 WHIP in his last three trips to the bump going into this evening.

The Cardinals need a positive response, and Mikolas is the perfect guy to have on the bump at Busch Stadium for that tonight. I like where the O’s are going, but the Cards should be at least 2 runs better in this one.


Orioles vs. Cardinals Pick
Kyle E / Author

Kyle is a veteran of TheSportsGeek and has spent nearly a decade providing accurate sports picks and writeups here. He has been a sports handicapper for 10+ years and started sharing his picks and thoughts in 2011 at TheSportsGeek. His expertise spans across multiple sports, including the NFL, NCAAF, MLB, NHL, and horse racing. Prior to writing for TheSportsGeek, Kyle was a fantasy football expert, who ultimately parlayed it into a successful sports betting career. You can find his picks daily only at TheSportsGeek.

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