St. Louis Cardinals vs Arizona Diamondbacks MLB Pick – September 25th

The MLB is set up with another exciting Wednesday of baseball as fifteen games hit the board for September 25. We are in the last few days of the MLB season as a few teams are left fighting for positioning and a playoff spot. One of the games on Wednesday afternoon will be between the St. Louis Cardinals and the Arizona Diamondbacks. This game will start at around 3:40 PM Eastern time.

St. Louis has earned a record of 90-68 to this point in the season, which has them sitting in the top spot of the NL Central. The Cardinals hold a three and a half-game lead in their division as they try and lock it up. St. Louis has won six of their last seven games and will look to keep this strong stretch going as they earn another road victory to finish out this series.

The Diamondbacks have posted a record of 81-77 to this point in the season, which is good enough for second place in the NL West. Arizona has recently been eliminated from this season’s postseason run. The Diamondbacks have lost ten of their last sixteen games, which has not helped their cause. Arizona will still try and end the season strong.

These two teams have had strong seasons, but unfortunately for the Diamondbacks, they have been eliminated from postseason contention. St. Louis still has not secured their spot as division winners, so they will come out and look to win the final game of this series. I expect a strong final matchup between the Cardinals and the Diamondbacks.

Previous Matchups

The first series of the season was in St. Louis between July 12-14. The first game was a strong one, but a two-run homer by Ketel Marte ultimately gave the Diamondbacks a 4-2 win. The second game was another strong one. Tyler O’Neill racked in four RBI’s as he had a homer and a double to give the Cardinals a 4-2 win. Adam Wainwright had a strong start in the final game as he allowed four hits and no runs through seven innings to help St. Louis win 5-2.

The first game of this series was on September 23 in Arizona. Tommy Edman, Paul Goldschmidt, Yadier Molina, and Harrison Bader all hit home runs for the Cardinals to help them earn an important win. St. Louis was able to get the hits early and hold off the Diamondbacks push just enough to escape with a 9-7 win.

Last night’s late matchup was the second game of the series. Dexter Fowler hit a home run early to get it started. Ildemaro Vargas tied it up in the bottom of the ninth with a solo homer of his own. Caleb Joseph then tied it up again in the bottom of the thirteenth. Vargas hit a walk-off single in the bottom of the nineteenth inning to give the Diamondbacks a 3-2 win.


Paul Goldschmidt has been putting up a really strong season for St. Louis. Goldschmidt has earned 151 hits, 33 home runs and 95 RBI’s. Kolten Wong has 136 hits, 11 homers and 59 RBI’s. Paul DeJong has 135 hits, 29 homers and 77 RBI’s, while Marcell Ozuna has posted 114 hits, 29 home runs and 88 RBI’s. Seven other players have hit double-digit home run numbers for the Cardinals this season.

Eduardo Escobar has earned 169 hits, 35 home runs and 118 RBI’s on the season. Nick Ahmed has put up 138 hits, 19 homers and 81 RBI’s. Christian Walker has 134 hits, 27 homers and 67 RBI’s. Adam Jones has posted 125 hits, 16 homers and 66 RBI’s. Carson Kelly has 76 hits, 18 home runs and 46 RBI’s on the season.

St. Louis is missing Kolten Wong for Wednesday afternoon’s game. The Diamondbacks have been hit hard by Ketel Marte’s injury who is out for the season. The Cardinals hitting lineup is slightly better, but both teams have some players that can beat you deep. The pitchers will look to keep the game like last night instead of the first game of the series.


Michael Wacha will be the starting pitcher for Wednesday’s afternoon game. Wacha has gone 6-7 through 28 games this season. He has earned an ERA of 4.68 and a 1.536 WHIP in those games. Wacha’s last start came against the Chicago Cubs. He pitched four innings and allowed five hits and one run in a no decision.

Merrill Kelly will be the starter on the mound for Arizona in this matchup. Kelly has a record of 12-14 through his 31 starts. He has put up a 4.31 ERA and a WHIP of 1.303. Kelly’s last start was against the San Diego Padres, where he allowed two hits and no runs through seven innings as he won his second win in a row and third in four starts.

Kelly has had the better season stat wise so far. Wacha has gone less than six innings in his last four starts and he could have another shorter night in this game. If Kelly can put up another long start, I believe it could be enough to give the edge to Arizona to pull off the win. This pitcher duel should be a good one early.

Pick Overview

After late night’s game, I believe both teams will be a bit tired for this afternoon’s game. I believe that this gives St. Louis an advantage that will lead to their victory. The Cardinals have a better depth hitting lineup and Wacha has been doing well as of late. I believe that he is due for a later and stronger night, which could help St. Louis get the win.

BetOnline has the Cardinals listed as a -115 against the money line. This gives a slight edge to the road team as they try and take this series. I believe that this line is accurate and has quite a bit of value. I like St. Louis to take this game and as only slight favorites in this game, I think that the Cardinals are a good bet.

The Bet
Andruw Burling / Author

Andruw Burling has been writing sports picks since 2017, covering mainly NHL and NBA content, but doing work in other sports as well. Andruw grew up in Las Vegas and has been around sports since a young age. He grew up a huge NHL and NBA fan and continues to use that knowledge in his content today.