Chicago Cubs vs. Arizona Diamondbacks Pick – MLB May 13, 2022

The Chicago Cubs are in the desert for a three-game series at Chase Field. They are coming off a three-game series in San Diego against the Padres.

Their trip to San Diego went pretty well with a series win. The Cubs won two of three games, including the rubber match on Wednesday, 7-5.

Keegan Thompson lasted 4 innings with 5 hits and 2 earned runs allowed. The offense took care of the rest of the work, as they punched Nick Martinez for 4 hits and 5 earned runs.

The Cubs aren’t where they’d like to be at this point in the season, though. They enter Chase Field with 11-19 and eight games behind the Milwaukee Brewers for the lead in the NL Central.

Chicago has six losses in their previous eight attempts. They haven’t gotten off to a hot start, but there weren’t too many expectations for them in 2022.

The Cubs were a wildcard team, with anything possible from this squad. They can certainly be better than eight games below .500.

The Diamondbacks are off to a promising start this season after a disastrous campaign in 2021. They finished at 52-110 and last in the National League.

They’re off to a 17-15 start this season. I don’t think it comes as too much of a surprise. The Diamondbacks have had some young talent brewing in their minor league system.

This is a season about progress, and then perhaps in the next two years, the Diamondbacks are going to compete again. Arizona will send Zach Davies to the bump while Drew Smyly counters for the Cubs.

Head below for our free Cubs vs. Diamondbacks pick on May 13, 2022.

Chicago Cubs vs. Arizona Diamondbacks Live Betting Odds:

The following odds are courtesy of Bovada:
Teams Spread Moneyline Total
Chicago Cubs +1.5 (-185) -102 Over 9 (-105)
Arizona Diamondbacks -1.5 (+160) -118 Under 9 (-115)
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Team Data Chicago Cubs Arizona Diamomdbacks
Overall Record 11-19 17-15
Away/Home Record 7-8 9-9
Batting Average .237 .199
Batting Average Away/Home .246 .181
Runs Per 9 4.11 3.71
Team ERA 4.22 3.55
Team ERA Away/Home 4.57 3.18

Cubs vs. Diamondbacks Prediction:

The Cubs are looking to get more productivity out of Drew Smyly tonight. Smyly has been fine going into Friday night. He enters with an ERA of 3.04 and a 1.23 WHIP through five games.

Smyly is going into Chase Field with an ERA of 5.14 ERA and a 1.50 WHIP in his previous three attempts. He doesn’t have a win with a record of 0-3 during that time against the Dodgers, Braves, and Pirates.

Smyly allowed 6 hits and 2 earned runs through 4.1 innings of work in his latest start. This was a tough assignment versus the Dodgers, so Smyly didn’t have it easy.

Arizona needs to work in improving offensively, but the Diamondbacks’ pitching staff has been in good form.

Zach Davies has been tough on hitters this season. He’s been on fire in his most recent outings.

The former Milwaukee Brewer enters with an ERA of 3.34 and a 1.21 WHIP.

Chicago Cubs vs. Arizona Diamondbacks Betting Trends:


  • Record (Last 10): 3-7
  • 1-5 overall in their previous first game of a series
  • 0-5 overall in their previous five games after a win
  • 0-4 overall in their previous four games after scoring 5 or more runs
  • 15-41 overall in their previous 56 games versus a team with a winning record
  • 10-26 overall in their previous 26 games versus a right-handed starter


  • Record (Last 10): 7-3
  • 5-1 overall in their previous six games as a betting favorite
  • 6-2 overall in their previous eight games at home
  • 5-1 overall in their previous six games as a betting favorite at home
  • 5-1 overall in their previous six games after their opponent concedes 5 or more runs
  • OVER is 4-1-2 in their previous seven games as an underdog

  • Davies has been on fire with just 6 hits and no runs allowed in his previous two games. He went 11.1 innings without allowing a run in those performances.

    The Cubs are hitting .122 with 3 home runs against Davies in 84 at-bats. He played for the Cubs in 2021 and would like to show them up in this one.

    Davies posted an ERA of 5.78 and a 1.60 WHIP last season after having success with the Padres and Brewers. The Cubs quickly gave up on Davies following that campaign.

    I’m sure that Davies is motivated to pitch well against a team that wanted to send him packing after one season.

    He has a good history against this lineup, so Davies may not need the motivation. I’m on the D-backs to open this three-game tilt with a win at home over the Cubs.


    Cubs vs. Diamondbacks Pick
Kyle E / Author

Kyle is a veteran of TheSportsGeek and has spent nearly a decade providing accurate sports picks and writeups here. He has been a sports handicapper for 10+ years and started sharing his picks and thoughts in 2011 at TheSportsGeek. His expertise spans across multiple sports, including the NFL, NCAAF, MLB, NHL, and horse racing. Prior to writing for TheSportsGeek, Kyle was a fantasy football expert, who ultimately parlayed it into a successful sports betting career. You can find his picks daily only at TheSportsGeek.

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