Chicago White Sox vs. Seattle Mariners Pick – MLB April 6, 2021

The Chicago White Sox and Seattle Mariners are scheduled to meet for the second game of this three-game series on Tuesday night. The White Sox put together a high-quality performance to jump out ahead in the first matchup. Carlos Rodon went into lockdown mode on the hill, as he conceded just 2 hits and no earned runs through 5 innings of work.

Rodon notched 9 strikeouts in an impressive showing for the White Sox. It was a rough series in Anaheim for the White Sox, so it must have been nice to put together a complete outing. Yasmani Grandal was responsible for 3 runs, as he went 2-for-4 with a deep home run. When your catcher is raking at the plate, that’s a big positive.

The White Sox didn’t need much offense with how Rodon was dealing on the bump. Justus Sheffield had a rough go of it to open the 2021 campaign. He allowed 8 hits, 2 walks, and 4 earned runs. The White Sox out hit the Mariners 10-3, so the win was much deserved on Monday night.

They were able to quickly bounce back after a tough 7-4 loss against the Los Angeles Angels on Sunday Night Baseball. After tying the game up at 4-4 in the top of the 9th, the Angels scored 3 runs in the bottom half to take back the lead for good. The White Sox won behind a big offensive performance Friday, 12-8, but losses in three of four games.

Lucas Giolito received the Opening Day nod on Thursday in Anaheim. The loss was at no fault of Giolito, who held up well with 2 hits and 2 earned runs conceded. Giolito lasted 5.1 innings on the bump. Those were the only 2 earned runs that were allowed by the White Sox. A White Sox error helped give the Angels the edge on the scoreboard. Giolito hopes to receive some better run support in his second attempt in 2021.

The Mariners slipped to 2-2 on the season with the loss. They had some success to open the season with two wins against the San Francisco Giants, 8-7 and 4-0. Chris Flexen was terrific in the series finale against the Giants. He went 5 innings with 4 hits and no runs allowed. James Paxton, who has circled back to Seattle after failing in New York, looks to get his career back on track in a familiar setting. Head below for our free White Sox vs. Mariners pick on April 6, 2021.

Chicago White Sox vs. Seattle Mariners MLB Betting Odds:


  • White Sox -1.5 (+110)
  • Mariners +1.5 (-130)

  • White Sox -138
  • Mariners +128

  • Over 7.5 (-115)
  • Under 7.5 (-105)


White Sox vs. Mariners Prediction:

Lucas Giolito did his part on Opening Day, but failed to receive much run support from the offense. Giolito is off to a solid start with a 3.38 ERA and 0.75 WHIP. The Angels hit just .111 against Giolito, though the White Sox managed to lose the game. The Angels have a fairly strong lineup, so Giolito chewing through them like that was an impressive way to open the season. Giolito held teams to a .184 batting average last season, so no surprise that he held the line against the Angels.

He had a terrific spring training as well. Giolito posted an ERA of 1.17 and 0.87 WHIP through 23 innings. That form was able to carry over in the regular season against the Angels. His counterpart on the other side tonight, James Paxton, is looking to get back to form in Seattle. The Big Maple started his major league career in Seattle in 2013 and spent six years there before signing a big contract to play for the Yankees.

Like Sonny Gray, Paxton failed as a Bronx Bomber. Gray regained his form when he exited New York, so we’ll see if it’s the same for Paxton. Paxton recorded an ERA of 6.64 and 1.48 WHIP last season with the Yankees through just five starts and 20.1 innings. Injuries were a big part of Paxton failing to stick in New York, too. He couldn’t stay healthy last year, which certainly didn’t help matters. Paxton pitched 8.1 innings in spring training and held up well with 4 hits and 1 earned run allowed.

He was strong in spring training with the Yankees, though, so maybe not the best barometer to measure his future success in the regular season. The White Sox are hitting .333 against lefties this season, which continues the trend from last season. In 2020, the White Sox hit .254 against righties and .285 against left-handed pitching. Despite only five games into the regular season, we already know that the White Sox are great against lefties. This looks like a good spot to back Giolito at a reasonable price.


Our Bet
Kyle E / Author

Kyle is a veteran of TheSportsGeek and has spent nearly a decade providing accurate sports picks and writeups here. He has been a sports handicapper for 10+ years and started sharing his picks and thoughts in 2011 at TheSportsGeek. His expertise spans across multiple sports, including the NFL, NCAAF, MLB, NHL, and horse racing. Prior to writing for TheSportsGeek, Kyle was a fantasy football expert, who ultimately parlayed it into a successful sports betting career. You can find his picks daily only at TheSportsGeek.