Houston Astros vs. Los Angeles Angels Pick – MLB April 5, 2021

The Houston Astros and Los Angeles Angels get a brief two-game series underway at Angel Stadium on Monday night. The Angels are coming off a wild win to get out to a 3-1 start in the 2021 campaign. After the White Sox forced a tie in the top of the 9th following a quiet 3 innings with no runs, the Angels responded with 3 runs in the bottom of the 9th to avoid extra innings. Tough beat if you had the UNDER in that matchup. That is going to happen if you bet on baseball enough, though. Avoiding bad beats is impossible if you’re going to wager on Major League Baseball regularly. One game on the bump and already Shohei Ohtani is limping off the field.

According to reports, Ohtani is fine, but he had a collision at home plate and was removed from the game with a limp. Angels’ fans are keeping their fingers crossed that Ohtani can stay healthy for a whole season, but getting through one game seems to be a problem for him. There was speculation that Ohtani was only going to be a one-way player, but he’s doing his best to live up to his original billing as a dominant force on the hill and at the plate. It’s crazy to think that he’s already a 26-year-old. If it weren’t for injuries, he’d maybe be living up to expectations, but we haven’t seen enough out of him as a pitcher.

Note that Ohtani was not scheduled to play against the Astros tonight anyway. He played in all four games in the opening series against the White Sox and pitched last night. Ohtani will be evaluated because of the injury, but reports suggest it is not serious, fortunately. It’s a strong start this season for the Angels. The White Sox are a quality opponent and the Angels took three of four games against them. We’ve seen this act before from the Angels before, though. They can look great in one series and completely lost in the next.

The Astros are fresh off a 9-2 blowout of the Oakland Athletics on Sunday. It was their fourth straight win and a sweep of the A’s. Chas McCormick at the back of the lineup was responsible for the most offense for the Astros. He cleared the bases with one swing of the stick for a 3 RBI night at the plate. For the third consecutive game, the Astros scored 9 runs. Combined with 8 runs on Opening Day, the Astros scored 35 runs in four games. Not too bad of a start at the dish. Head below for our free Astros vs. Angels pick on April 5, 2021.

Houston Astros vs. Los Angeles Angels MLB Betting Odds:


  • Astros +1.5 (-180)
  • Angels -1.5 (+160)

  • Astros +105
  • Angels -115

  • Over 9.5 (-110)
  • Under 9.5 (-110)


Astros vs. Angels Prediction:

The Astros are swinging a hot bat going into Anaheim. It will be on Jose Quintana of the Angels to slow down the Astros’ offense. They’ve been getting production from up and down their lineup to open the season. Despite facing resistance from fans in Oakland, the Astros used it as motivation to sweep the Athletics. They very well could use that motivation to prove people wrong all season long. It certainly seemed to be true for at least one series.

Quintana must be focused and ready to perform tonight. Since recording an ERA below 4.00 in six of his first seven seasons in the majors, Quintana has regressed a bit and has posted an ERA above 4.00 in three straight years. He had a career-low ERA of 4.68 in 2019, and then followed up with a 4.50 ERA last season in his final season with the Cubs. Quintana still belongs in a major league rotation, but his better days are behind him at this juncture. He’s conceded 9 RBI against the Astros across 89 at-bats in his career. With the ‘Stros bats on fire, Quintana has a big chore ahead of him on Monday night.

Luis Garcia got his feet wet in the major leagues a season ago. He made a total of five appearances with one start. Garcia held up well with an ERA of 2.92 and 0.97 WHIP. Opponents were hitting just .167 against him. However, it can often be difficult to duplicate that success in the following season. Especially in a season where he only made five starts through 12.1 innings. A lot more is going to be asked of him this season as a member of the rotation. His spring training was rocky to say the least.

Garcia posted an ERA of 7.94 and 1.94 WHIP. Instead of a .167 batting average, the opposition was hitting .333 against Garcia. The Angels were stymied against Garcia in his MLB debut last season. They scored just 1 earned run on a long ball. This time around, expect the Angels to have a better grasp on Garcia. The OVER has gone 9-0 in their last nine meetings with an average of 13.5 runs scored during that stretch. I’m on the OVER in what should be an entertaining contest in Anaheim.


Our Bet
OVER 9.5
Kyle E / Author

Kyle is a veteran of TheSportsGeek and has spent nearly a decade providing accurate sports picks and writeups here. He has been a sports handicapper for 10+ years and started sharing his picks and thoughts in 2011 at TheSportsGeek. His expertise spans across multiple sports, including the NFL, NCAAF, MLB, NHL, and horse racing. Prior to writing for TheSportsGeek, Kyle was a fantasy football expert, who ultimately parlayed it into a successful sports betting career. You can find his picks daily only at TheSportsGeek.