Houston Astros vs. Minnesota Twins Pick – MLB May 10, 2022

The Houston Astros and Minnesota Twins open a three-game series at Target Field on Tuesday night. Houston is coming off a sweep of the Detroit Tigers this past weekend. They leaned heavily on their pitching staff in three 3-2 wins and a 5-0 win on Sunday.

In their most recent matchup, Jake Odorizzi was in great form through 5 innings. Odorizzi allowed just 1 hit, and the bullpen took care of the rest for the Astros. Christian Javier and Hector Neris combined to prevent no hits on the bump.

Houston is on a seven-game winning streak going into Minnesota. They haven’t lost since a 3-2 final against the Toronto Blue Jays on May 1. The pitching staff has been unhittable over the last two weeks.

The Astros are going into Minnesota with a record of 18-11 and a game behind the LA Angels for the lead in the AL West. Yes, the Angels finally look like they’re for real in the Mike Trout era for once.

Could the AL West be a duel between the Astros and Angels? I put the Astros ahead of the Angels for their pitching staff, but we’ll see. There is a lot of baseball to be played through the summer.

The Twins equal the Astros, as they go into Tuesday with a record of 18-11. They’re coming off a sweep of the Oakland Athletics following a 4-3 win on Sunday. The Twins allowed just 4 runs through three games, including a 2-1 and 1-0 win.

Minnesota has won seven of their previous nine attempts. In a division that was expected to be wide-open this season, the Twins have a three-game advantage on the Cleveland Guardians.

It was expected to be wide-open, but the Twins were not a top contender to win the AL Central.

The Astros are scheduled to send Justin Verlander to the mound against Joe Ryan of the Twins. No, this Ryan is not related to Nolan Ryan if that’s what you were wondering. He’s off to a red-hot start in his first full-time season after getting his feet wet in 2021.

Head below for our free Astros vs. Twins prediction on May 10, 2022.

Houston Astros vs. Minnesota Twins Live Betting Odds:

The following odds are courtesy of Bovada:
Teams Spread Moneyline Total
Houston Astros -1.5 (+130) -142 Over 7 (-105)
Minnesota Twins +1.5 (-150) +119 Under 7 (-115)
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Team Data Houston Astros Minnesota Twins
Overall Record 18-11 18-11
Away/Home Record 9-7 11-4
Batting Average .218 .235
Batting Average Away/Home .214 .228
Runs Per 9 5.19 3.90
Team ERA 3.96 4.18
Team ERA Away/Home 3.66 4.37

Astros vs. Twins Prediction:

The Astros have been getting timely pitching this season from their entire staff. They are the fourth-best team in the majors, with 3.30 runs allowed per 9 innings. Teams are hitting just .216 versus the Astros this season.

The Astros have a cumulative ERA of 2.95 and 1.10 WHIP as a team. This goes for the rotation and bullpen. The bullpen is the second-best unit in the majors with a 2.61 ERA and 1.13 WHIP. Unfortunately for the Twins, they have to deal with Justin Verlander tonight.

Verlander is looking to build on a hot start this season. This is to be expected from JV, but there were some question marks if his arm was still alive after sitting out a year ago. He still appears in prime form off an injury and 39 years old.

Verlander is going into this evening with an ERA of 1.93 and a 0.70 WHIP. His opponents have tallied a pedestrian OBP of .203.

His best work has come on the road in 2022. Verlander has notchd an ERA of 0.90 and a 0.65 WHIP through 20 innings away from Minute Maid Park.

The Twins are hitting .165 with 3 home runs against Verlander in 66 at-bats. It isn’t just Verlander. Minnesota will have to contend with a dangerous ‘Stros bullpen, too.

Houston Astros vs. Minnesota Twins Betting Trends:


  • Record (Last 10): 8-2
  • 7-0 overall in their previous seven games
  • 10-1 overall in their previous 11 games as a betting favorite
  • UNDER is 4-0 in their previous four games versus the NL Central
  • UNDER is 6-1 in their previous seven games on the road
  • UNDER is 7-1 in their previous eight games after one-day off


  • Record (Last 10): 7-3
  • 9-0 overall in their previous nine games at home
  • 5-1 overall in their previous six games as an underdog
  • UNDER is 13-3-2 in their previous 18 games as an underdog at home
  • UNDER is 13-2-2 in their previous 17 games versus the AL West
  • UNDER is 3-1-1 in their previous five games at home

The Twins likely have to rely on Joe Ryan to pitch better than Verlander in this one. Ryan could make do it considering his recent form.

He made five starts last season with a 4.05 ERA and 0.79 WHIP. There was a lot of promise with that one, and in five attempts this season, Ryan has a 1.63 ERA and 0.83 WHIP.

There are always two or three young pitchers that emerge every year. Ryan could be one of those rookies that break out in a big way. He is going into this one with an ERA of 1.02 and a 0.68 WHIP in his previous three starts.

The Astros haven’t been that strong at the plate. They’ve relied heavily on their pitching. The offense isn’t that hot at the moment.

Houston is 27th in the majors with a batting average of .217. They’ve scored 3.86 runs per 9 innings for 23rd.

Note that The Twins are the third-best pitching staff going into Tuesday. Teams have scored just 3.25 runs per 9 innings against Minneosta pitching this season. Ryan has played a role in giving the pitching staff a nice lift.

I’m looking at a 3-2 or 4-2 final at Target Field in this series opener in Minnesota. It should be a close call late in the game, with the winner coming down to the bullpens. I’d bet the UNDER in a low-scoring contest.


Astros vs. Twins Pick
Kyle E / Author

Kyle is a veteran of TheSportsGeek and has spent nearly a decade providing accurate sports picks and writeups here. He has been a sports handicapper for 10+ years and started sharing his picks and thoughts in 2011 at TheSportsGeek. His expertise spans across multiple sports, including the NFL, NCAAF, MLB, NHL, and horse racing. Prior to writing for TheSportsGeek, Kyle was a fantasy football expert, who ultimately parlayed it into a successful sports betting career. You can find his picks daily only at TheSportsGeek.

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