Houston Astros vs. Seattle Mariners Pick – MLB May 27, 2022

The Houston Astros and Seattle Mariners are at T-Mobile Park for a three-game series. The ‘Stros are in Seattle following back-to-back wins over the Cleveland Guardians.

They dropped the series opener, 6-1, but fired back with a 7-3 and 2-1 win. In their most recent win, the Astros rode the hot arm of Cristian Javier to a 2-1 win at Minute Maid Park. Javier allowed 3 hits and no runs across 5.2 innings of work.

The Guardians added a run in the top of the 7th against Blake Taylor to mess with the runline, but that was their only offensive production. With the win, the Astros are a 29-16 team with a 2.5-game advantage on the LA Angels.

The Astros are in control of the AL West, with the Texas Rangers eight games back the next closest team besides the Angels. How much confidence does anyone have in the Angels staying up with the Astros?

Mike Trout and the Angels are running out of excuses if they can’t do it this season. The pitching staff is finally doing their part, so we’ll see if that sticks. Houston has no problems with their pitching staff, especially tonight with Justin Verlander on the mound.

The Mariners are looking to end a seven-game losing streak tonight.

Seattle is coming off a 4-2 loss to the Oakland Athletics on Wednesday. That was a tough couple of games as heavy favorites in both versus a beatable opponent.

The Mariners were coming off getting swept against the Boston Red Sox in four games. As a result of this recent slide, the Mariners have regressed to 18-27 and last in the AL West.

Houston has an 11-game advantage on the Mariners going into the series opener. They handled the Mariners easily in their latest series earlier this month.

It was an easy sweep for the ‘Stros at Minute Maid Park, with a 3-0, 4-0, and 7-2 win. Verlander will look to keep it on versus the Mariners. Chris Flexen is expected to start at home in this one.

Head below for our free Astros vs. Mariners prediction on May 27, 2022.

Houston Astros vs. Seattle Mariners Live Betting Odds:

The following odds are courtesy of Bovada:
Teams Spread Moneyline Total
Houston Astros -1.5 (-125) -210 Over 7.5 (+100)
Seattle Mariners +1.5 (+140) -135 Under 7.5 (-120)
Betting Site
Bonus Bet Now
1BetOnline Logo BetOnline
50% up to $1,000 Go to Site
2 Bovada
50% up to $1,000 Go to Site
3 BetUS
125% up to $2,500 Go to Site
4 Everygame
100% up to $500 Go to Site
5 SportsBetting.ag
100% up to $1,000 Go to Site
6 MyBookie
100% up to $1,000 Go to Site
Team Data Houston Astros Seattle Mariners
Overall Record 29-16 18-27
Away/Home Record 15-10 10-9
Batting Average .229 .232
Batting Average Away/Home .232 .250
Runs Per 9 4.35 4.00
Team ERA 2.81 4.35
Team ERA Away/Home 3.29 3.96

Astros vs. Mariners Prediction:

Justin Verlander is getting older, but he continues to get better like a fine wine. Verlander is also coming off an injury. He had one start in 2020 and missed all of last season.

Despite missing time, Verlander is looking better than ever across eight starts. He is going into T-Mobile Park with an ERA of 1.22 and a 0.72 WHIP. In 33 innings on the road, Verlander is on fire with a 0.55 ERA and a 0.64 WHIP.

JV has been untouchable in his most recent outings. In his previous three starts, Verlander has a 0.00 ERA and 0.64 WHIP.

The 39-year-old blanked the Twins, Nationals, and Rangers going into Seattle. He’s seen the Mariners twice this season, both resulting in wins of 4-0 and 7-2. Verlander allowed 2 earned runs in 14.2 innings.

The Mariners are mediocre at the plate, and a matchup against Verlander likely isn’t going to improve anything.

In 64 at-bats, the Mariners are hitting .193 with a .227 OBP against Verlander. While the offense can be better, it’s the pitching letting the Mariners down.

They are 29th in the majors with 1.4 home runs allowed per game and a .746 OPS against for 27th. The Mariners are 24th with 4.74 runs allowed per 9 innings and a team ERA of 4.35 as opposed to a 2.81 ERA for Houston.

Houston Astros vs. Seattle Mariners Betting Trends:


  • Record (Last 10): 6-4
  • 9-1 overall in their previous ten games versus the AL West
  • 4-1 overall in their previous five games versus a team with a losing record
  • 7-2 overall in their previous nine games versus a right-handed starter
  • 15-6 overall in their previous 21 games after a win
  • 4-1 overall in their previous five games versus the Mariners


  • Record (Last 10): 2-8
  • 3-7 overall in their previous ten games at home
  • 1-4 overall in their previous five games after a loss
  • 1-6 overall in thier previous seven games versus the AL West
  • 0-5 overall in their previous five games versus a right-handed starter
  • 2-6 overall in their previous eight games in the first matchup of a series

  • Chris Flexen is entering this one with an ERA of 4.98 and a 1.43 WHIP. The Mariners wanted to see better out of him this season. He posted a 3.61 ERA and 1.25 WHIP in a breakout campaign in 2021.

    Flexen has shown signs of regression, though, and a solid start versus the Astros would be good for his confidence.

    He’s going into tonight with an ERA of 8.79 and a 2.02 WHIP. Opponents have notched a .417 OBP versus Flexen in his last 15 innings on the hill.

    The ‘Stros are hitting .272 with 3 home runs and 10 RBIs against Flexen. They’ve had success, with 4 earned runs in 8 innings versus him this season.

    Flexen has the potential to be good in any given start, but it’s going to be tough with a red-hot JV on the other side. Look for Flexen to fail to keep pace, with the Astors edging away for a 6-3 win at T-Mobile Park.


    Astros vs. Mariners Pick
Kyle E / Author

Kyle is a veteran of TheSportsGeek and has spent nearly a decade providing accurate sports picks and writeups here. He has been a sports handicapper for 10+ years and started sharing his picks and thoughts in 2011 at TheSportsGeek. His expertise spans across multiple sports, including the NFL, NCAAF, MLB, NHL, and horse racing. Prior to writing for TheSportsGeek, Kyle was a fantasy football expert, who ultimately parlayed it into a successful sports betting career. You can find his picks daily only at TheSportsGeek.

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.