Miami Marlins vs. San Francisco Giants Pick – MLB April 22, 2021

The Miami Marlins and San Francisco Giants are scheduled to open a four-game series at Oracle Park on Thursday night. The Giants return home after a six-game road trip, which started in Miami and ended in Philadelphia. They lost two of three games against the Marlins, and then impressively won two of three against the Phillies. The Giants failed to complete the sweep on Wednesday, but it was still a good series for the Giants.

Like a lot of teams to open the season, the Giants have been up and down. However, there has been more good than bad for the Giants, as they head home with a record of 11-7. Winning the NL West is still going to be an impossible task, though. The Dodgers are already three games ahead, and the San Diego Padres are going to be a threat despite their slow start. That’s going to leave the Giants looking to reach the postseason another way.

The Giants very well could be the Marlins from last season in 2021. No one was expecting the Marlins to go to the postseason. They finished with a record of 31-29, and beat the Chicago Cubs in two straight games to win as a wildcard. The Marlins were prevented from going any further, but it was a successful shortened campaign nonetheless. Management just wanted to see progress from their team last season and that’s what they got.

Now comes the hard job of building on last season and improving. The Marlins have a bit of pressure now that people are expecting them to play solid baseball. No one is looking at the Marlins to go to the World Series, but there are expectations for another productive campaign. It’s too early to draw any conclusions, and that goes for the rest of the majors, not just the Marlins. They head into San Francisco with a record of 8-9. The Marlins are coming off a split against the Baltimore Orioles with a 7-5 loss and 3-0 win. Head below for our free Marlins vs. Giants pick on April 22, 2021.

Miami Marlins vs. San Francisco Giants MLB Betting Odds:


  • Marlins +1.5 (-156)
  • Giants -1.5 (+138)

  • Marlins +135
  • Giants -145

  • Over 8 (-128)
  • Under 8 (+107)


Marlins vs. Giants Prediction:

The Marlins will turn to lefty Daniel Castano to get this series started on Thursday night. Castano is off to a fine start after appearing in seven games last season. The 26-year-old rookie made six starts and a spot appearance out of the bullpen. He was rock solid with an ERA of 3.03 and 1.38 WHIP.

It was a good building block for Castano going into his first full season in the Marlins’ rotation. If he pitches like he did in his opening start against the Giants last week, then we’re going to see a lot of Castano with the Marlins this season. He gave up only 3 hits and 1 earned run in a 4-1 win over Anthony DeSclafani and the Giants.

Castano goes into the Bay Area with an ERA of 1.80 and 1.00 WHIP. He held the Giants to a .176 batting average in that outing. Castano is drawing a pretty big price as an underdog in the rematch in San Francisco. The oddsmakers and public aren’t confident in him duplicating that performance again. Veteran and former Toronto Blue Jay, Aaron Sanchez, will counter for the Giants.

Sanchez has been holding up pretty well with a 2.45 ERA and 1.23 WHIP through three starts and 14.2 innings. However, it’s tough to say if we can trust Sanchez. He hasn’t had a standout season since posting a 3.00 ERA and 1.17 WHIP in 2016 with the Blue Jays. Sanchez has regressed with each passing year, with a 4.25 ERA, 4.89 ERA, and 5.89 ERA between the Astros and Blue Jays last season.

The change of scenery didn’t help Sanchez much in Houston. He was expected to bolster the Astros’ rotation, but Sanchez never heated up. Sanchez recorded an ERA of 4.82 and 1.23 WHIP with the ‘Stros. I’m not at all interested in laying this price on Sanchez. You aren’t getting much value on the Giants in this spot. I will take my chances on the Marlins at this price to open up the series with a win.


Our Bet
Kyle E / Author

Kyle is a veteran of TheSportsGeek and has spent nearly a decade providing accurate sports picks and writeups here. He has been a sports handicapper for 10+ years and started sharing his picks and thoughts in 2011 at TheSportsGeek. His expertise spans across multiple sports, including the NFL, NCAAF, MLB, NHL, and horse racing. Prior to writing for TheSportsGeek, Kyle was a fantasy football expert, who ultimately parlayed it into a successful sports betting career. You can find his picks daily only at TheSportsGeek.

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