Minnesota Twins vs. Kansas City Royals Pick – MLB May 21, 2022

The Minnesota Twins and Kansas City Royals are on the diamond at Kauffman Stadium in Kansas City. The Twins opened this series last night with a 6-4 win.

Devin Smeltzer went 5.1 innings, with 5 hits and 1 earned run allowed, while Jose Miranda and Kyle Garlick chipped in with 2 RBIs each. They have the ultimate benefit of playing in the terrible AL Central.

Minnesota has no competition at the moment, with a record of 23-16 and a 3.5-game lead over the Chicago White Sox. The White Sox are at .500, with the Twins the only team in the AL Central better than even.

The Royals look like the worst team in the division this season. They are 1.5 games ahead of the Detroit Tigers for last, but the Tigers should pull ahead out of the basement over the Royals.

The Tigers are off to a slow start, though they are the better team than the Royals. That said, there have been some positives, notably in the pitching staff with Brad Keller and Zack Greinke. Greinke is wrapping his career up soon, though.

Keller is listed as No. 1 in the rotation and is the future as well. He is set to get the starting nod for the Royals at Kauffman tonight.

Rookie Joe Ryan is off to a quick start. He appeared in five games last year for an introduction to the major leagues. Ryan held up well in his first five starts, and he’s showing improvement in 2022.

Head below for our free Twins vs. Royals prediction on May 21, 2022.

Minnesota Twins vs. Kansas City Royals Live Betting Odds:

The following odds are courtesy of Bovada:
Teams Spread Moneyline Total
Minnesota Twins -1.5 (+115) -143 Over 7.5 (+100)
KC Royals +1.5 (-135) +120 Under 7.5 (-120)
Betting Site
Bonus Bet Now
1BetOnline Logo BetOnline
50% up to $1,000 Go to Site
2 Bovada
50% up to $1,000 Go to Site
3 BetUS
125% up to $2,500 Go to Site
4 Everygame
100% up to $500 Go to Site
5 SportsBetting.ag
100% up to $1,000 Go to Site
6 MyBookie
100% up to $1,000 Go to Site
Team Data Minnesota Twins KC Royals
Overall Record 23-16 14-24
Away/Home Record 10-8 8-13
Batting Average .238 .231
Batting Average Away/Home .245 .239
Runs Per 9 4.28 3.64
Team ERA 3.37 4.53
Team ERA Away/Home 3.74 4.17

Twins vs. Royals Prediction:

Joe Ryan has done everything asked of him this season. He started five games a season ago to gain some experience for 2022. Ryan posted an ERA of 4.05 and a 0.79 WHIP.

In his first full-time role in the rotation, Ryan is off to a fast start with the Twins. He’s learned from what he did wrong last season and has already appeared in more games in 2022.

Ryan is scheduled to make his eighth start this season. He made the rotation after a solid spring training and his form has carried over.

Ryan recorded an ERA of 2.39 and a 0.96 WHIP in seven attempts through 39.1 innings. He’s coming off a sharp outing against the Twins six days back.

Ryan held the Cleveland Guardains to 4 hits and 1 earned run across 6 innings of work.

His best effort has been on the road, where Ryan has posted an ERA of 1.67 and a 0.90 WHIP. He’s already looked in near-perfect form against the Royals.

Ryan shut down the Royals for 2 hits and no runs on April 21. In 12 at-bats against the Royals, they’re hitting .083 with no runs.

Minnesota Twins vs. KC Royals Betting Trends:


  • Record (Last 10): 5-5
  • 21-8 overall in their previous 29 games as a betting favorite
  • 10-1 overall in their previous 11 games versus the AL Central
  • 7-3 overall in their previous ten games on the road
  • UNDER is 5-2-1 in their previous eight games as a betting favorite
  • UNDER is 6-2-2 in their previous ten games versus a right-handed starter


  • Record (Last 10): 4-6
  • 3-9 overall in their previous 12 games at home
  • 1-9 overall in their previous ten games as an underdog at home
  • UNDER is 4-1 in their previous five games at home
  • UNDER is 11-3-1 in their previous 15 games versus the AL Central
  • UNDER is 4-1-1 in their previous six games at Kansas City

  • Brad Keller is atop the Royals’ rotation ahead of Zack Greinke. Keller is going into tonight with an ERA of 2.89 and a 1.01 WHIP. His best results have been at Kauffman in 2022.

    Keller has recorded an ERA of 1.71 and a 0.87 WHIP in 27 innings at home.

    The Twins are hitting .244 with 3 home runs versus Keller in 58 at-bats. Keller has shown plenty of improvement in his fifth season in the major leagues.

    Minnesota has the advantage in the bullpen. They’re one of the better units in the major leagues, with a team ERA of 3.39 and a 1.21 WHIP.

    Ryan and Keller are both emerging as solid options this season. Twins’ starter, Ryan, is especially a guy to become familiar with now before the secret is out on him.

    I’m looking at a 4-3 of 4-2 final at Kauffman on Saturday evening. The UNDER looks like the bet to side with between the Twins and Royals.


    Twins vs. Royals Pick
    UNDER 7.5
Kyle E / Author

Kyle is a veteran of TheSportsGeek and has spent nearly a decade providing accurate sports picks and writeups here. He has been a sports handicapper for 10+ years and started sharing his picks and thoughts in 2011 at TheSportsGeek. His expertise spans across multiple sports, including the NFL, NCAAF, MLB, NHL, and horse racing. Prior to writing for TheSportsGeek, Kyle was a fantasy football expert, who ultimately parlayed it into a successful sports betting career. You can find his picks daily only at TheSportsGeek.

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.