San Diego Padres vs. Arizona Diamondbacks Pick – MLB April 8, 2022

The San Diego Padres and Arizona Diamondbacks are back at Chase Field on Friday night. This is the second matchup of a three-game series in the desert. The Diamondbacks upset the Padres on Opening Day with a 4-2 win in the 9th.

Madison Bumgarner went 3 innings with a hit and earned run allowed before handing the ball over to the bullpen. The Diamondbacks’ bullpen were the stars of that one, as they held off the Padres from doing any more damage after taking a 2-0 lead in the 4th inning.

The Diamondbacks scored 4 runs in the final inning after going scoreless through 8 innings. Seth Beer connected in the bottom of the 9th with a 3-run bomb to complete the comeback. Yu Darvish had a strong performance, as he left after 6 innings with no hits allowed.

Robert Suarez was tagged for 2 walks and 3 earned runs. He and Craig Stammen combined to give up 4 earned runs with no outs recorded. Up to that point, it looked like the Padres were going to escape with a win despite just 4 hits.

Fernando Tatis Jr. was missing from the Padres’ lineup on Opening Day. After undergoing surgery to repair his wrist, Tatis Jr. will not be available for the first quarter of the regular season. Get used to seeing the Padres without Tatis Jr. for at least the next three months.

Sean Manaea is slated to get his first start as a Padre tonight. The former Oakland A signed with the Padres after six seasons in Oakland.

He stays in California, but is it a better spot for him? The D-backs counter with Merrill Kelly, who is entering his third season in the majors.

Head below for our free Padres vs. Diamondbacks prediction on April 8, 2022.

San Diego Padres vs. Arizona Diamondbacks Live Odds and Betting History:

The following odds are courtesy of Bovada:

Teams Spread Moneyline Total
San Diego Padres -1.5 (+110) -140 Over 9 (-115)
Arizona Diamondbacks +1.5 (-130) +117 Under 9 (-105)
Team Data San Diego Padres Arizona Diamondbacks
Overall Record 0-1 1-0
Away/Home Record 0-1 1-0
Batting Average .138 .115
Batting Average Away/Home .138 .115
Runs Per 9 2.00 4.00
Team ERA 4.50 2.00
Team ERA Away/Home 4.50 2.00

Padres vs. Diamondbacks Prediction:

Sean Manaea was a steady arm in the rotation for the Athletics in his career. He wasn’t the best pitcher in the American League, but was always a dependable option for the Athletics.

Manaea posted an ERA of 3.86 and a 1.20 WHIP in six seasons with the A’s. Manaea was consistent and never took his team out of games.

He recorded an ERA of 3.91 and a 1.23 WHIP through 32 games in his last season in Oakland. His work against the Diamondbacks has been notable in his career.

The Diamondbacks are hitting just .146 with a .196 OBP versus Manaea across 27 at-bats. This lineup has recorded a double just twice against him.

Merrill Kelly has been decent through his first three seasons, but is looking for more in 2022. Kelly wanted to break out last year, though didn’t exactly get to that point.

San Diego Padres vs. Arizona Diamondbacks Betting Trends:


  • Record (Last 10): 0-1
  • 5-12 overall in their previous 17 games as a favorite on the road
  • 0-4 overall in their previous four games as a betting favorite
  • 16-37 overall in their previous 53 games
  • OVER is 5-2 in their previous seven games as a betting favorite
  • OVER is 8-3 in their previous 11 games after scoring 2 or fewer goals


  • Record (Last 10): 1-0
  • 1-4 overall in their previous five games versus a team with a left-handed starter
  • 1-5 overall in their previous six games after their opponent scores 2 or fewer runs
  • 28-88 overall in their previous 116 games as an underdog
  • 17-47 overall in their previous 64 games versus the NL West
  • 5-22 overall in their previous 27 games on a Friday

Merrill Kelly posted an ERA of 4.44 and a 1.29 WHIP with a record of 7-11. It took Kelly a while to get the call up to the major leagues. The 33-year-old make his Major League debut in 2019, and he’s been fine for the Diamondbacks.

He finished with an ERA of 1.31 WHIP in his rookie campaign across 32 starts. He finished slightly worse last season after recovering from an injury the year before.

Kelly would have been a nice depth piece for a rotation. However, there isn’t much that Kelly could do to help the worst team in the National League. The Diamondbacks finished at 52-110 last season.

Look for the Padres and Diamondbacks to split the first two games of the 2022 campaign. The D-backs will put up a fight, but expect the Padres to get the edge at Chase Field.


Padres vs. Diamondbacks Pick
Kyle E / Author

Kyle is a veteran of TheSportsGeek and has spent nearly a decade providing accurate sports picks and writeups here. He has been a sports handicapper for 10+ years and started sharing his picks and thoughts in 2011 at TheSportsGeek. His expertise spans across multiple sports, including the NFL, NCAAF, MLB, NHL, and horse racing. Prior to writing for TheSportsGeek, Kyle was a fantasy football expert, who ultimately parlayed it into a successful sports betting career. You can find his picks daily only at TheSportsGeek.

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