San Francisco Giants vs. Colorado Rockies Pick – MLB May 16, 2022

The first of three games in Denver at Coors Field between the San Francisco Giants and Colorado Rockies is scheduled on Monday night. The Giants are coming off a humiliating loss at Busch Stadium on Sunday Night Baseball.

They were punched in the teeth early and often for a 15-6 loss. The Giants netted 4 runs in the top of the 9th, with Albert Pujols pitching, to make the final score look better, but it didn’t do much to hide that they were down by 13 runs going into the last frame.

Carlos Rodon had his worst performance of the season, as his Cy Young-like Campain suffered an early blow in St. Louis. The Cardinals battered Rodon for 10 hits and 8 earned runs in 3.2 innings.

Rodon had been pitching so well in his first season for the Giants, but that came to a halt at Busch Stadium. With the loss, the Giants lost back-to-back outings in St. Louis for two of three losses over the weekend.

The Giants dropped to 20-14 and 1.5 games behind the Dodgers and Padres in the NL West with the back-to-back losses. They head to Coors Field for a divisional showdown with the Rockies.

Colorado is on a skid with six losses in their previous seven attempts. They are coming off an entertaining 8-7 loss to the Kansas City Royals on Sunday. It was another high-scoring final at Coors as the temperatures heat up and the ball is flying.

Entertaining games are common at Coors Field, and it doesn’t necessarily mean that the Rockies are having a good time. They’ve won more games at home going into tonight, though.

The Rockies are going into tonight at Coors with a record of 12-7 in Denver.

Alex Wood and Antonio Senzatela are penciled in as the starters for the first game of this series tonight. Head below for our free Giants vs. Rockies prediction on May 16, 2022.

San Francisco Giants vs. Colorado Rockies Live Betting Odds:

The following odds are courtesy of Bovada:
Teams Spread Moneyline Total
San Francisco Giants -1.5 (+100) -150 Over 12 (-110)
Colorado Rockies +1.5 (-120) +126 Under 12 (-110)
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Team Data San Francisco Giants Colorado Rockies
Overall Record 20-14 17-17
Away/Home Record 9-7 12-7
Batting Average .244 .260
Batting Average Away/Home .229 .279
Runs Per 9 5.11 4.88
Team ERA 3.70 4.91
Team ERA Away/Home 3.64 4.68

Giants vs. Rockies Prediction:

Antonio Senzatela needs to settle down and into a groove for the Rockies. He’s been too inconsistent, with the Rockies not knowing what they will get from him on any given night.

Senzatela is going into tonight with an ERA of 4.88 and a 1.95 WHIP. He’s conceded a .426 OBA, with hitters finding it easy to reach base against the sixth-year righty.

The shortened season in 2020 was a career-high for Senzatela, as he recorded a 3.44 ERA through 12 starts. He is trending back towards his career average since then, though.

Senzatela finished with a 4.42 ERA and 1.34 WHIP last year. He’s close to his career ERA entering Monday night at Coors Field.

Senzatela has a career ERA of 4.85 and a 1.43 WHIP. Across 29.1 innings in 2022, Senzatela has notched a 4.88 ERA and 1.95 WHIP. Senzatela posted an ERA of 5.02 and a 1.88 WHIP in his last three starts.

Putting too many runners on base at Coors is going to lead to quick damage, and it’s been a problem versus the Giants. San Francisco is hitting .375 with a .439 against Senzatela in 97 at-bats.

San Francisco Giants vs. Colorado Rockies Betting Trends:


  • Record (Last 10): 6-4
  • 1-5 overall in their previous six games after a loss
  • 40-15 overall in their previous 55 games versus the NL West
  • OVER is 4-1 in their previous five games after a loss
  • OVER is 5-1 in their first game of a series
  • OVER is 4-0 in their previous four games versus the NL West


  • Record (Last 10): 3-7
  • 6-2 overall in their previous eight games at home
  • 5-16 overall in their previous 21 games versus the NL West
  • OVER is 6-0 in their previous six games
  • OVER is 5-0 in their previous five games after a loss
  • OVER is 5-1 in their previous six games versus a left-handed starter

  • This season, Alex Wood has been holding up fine with an ERA of 3.60 and a 1.37 WHIP through 117 at-bats. The Rockies are always tough at home, though.

    The Rockies are hot offensively with a .279 batting average and 6.74 runs per 9 innings at Coors Field. Overall, they are first in the majors with a .260 average and eighth with 4.85 runs per 9 frames.

    Colorado has put up 14 RBIs across 119 at-bats versus Wood in his career. There are seven batters in the lineup hitting better than .313 against Wood.

    The ball is flying around the yard at Coors Field recently.

    The Giants are a team that has been known for their pitching, but they have been more of an offensive team. They are second with 5.05 runs scored per 9 innings going into this one.

    San Francisco is in the top-10 in the major offensive categories, including home runs and OPS. If Wood isn’t perfect tonight, they should handle Senzatela.

    I’m looking at another high-scoring game at Coors Field. Look for more runs on the board in Denver, with the OVER the best bet between the Giants and Rockies.


    Giants vs. Rockies Pick
    OVER 12
Kyle E / Author

Kyle is a veteran of TheSportsGeek and has spent nearly a decade providing accurate sports picks and writeups here. He has been a sports handicapper for 10+ years and started sharing his picks and thoughts in 2011 at TheSportsGeek. His expertise spans across multiple sports, including the NFL, NCAAF, MLB, NHL, and horse racing. Prior to writing for TheSportsGeek, Kyle was a fantasy football expert, who ultimately parlayed it into a successful sports betting career. You can find his picks daily only at TheSportsGeek.

  1. I had San Fran and the Over, now on 44-23 run. Groooooooooooovy Boooooooooooming

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