San Francisco Giants vs. St. Louis Cardinals Pick – MLB May 15, 2022

The San Francisco Giants and St. Louis Cardinals headline Sunday Night Baseball on ESPN to wrap up the weekend card. After splitting the last two days, this is the rubber match to decide a series winner.

San Francisco got things started with an 8-2 win on Friday night. Jordan Hicks was fine through 5 innings, with 3 hits and 3 earned runs allowed. However, the bullpen offered no help.

The Cardinals responded with a 4-0 win behind a stellar performance from Dakota Hudson. Hudson went 5 innings of scoreless pitching on the bump.

Jakob Junis put in good work through 5.2 innings of work. Junis was tagged for 6 hits and 2 earned runs, but no run support caved in on the Giants on Saturday.

With the loss, the Giants dropped to 20-13 on the season, but remain within striking distance of the Dodgers and Padres. The Giants are just a half-game behind for the lead in the NL West.

Does this look like we could have a three-team race in the NL West this season? It’s setting up to be a thrilling season in this division a year after the Padres bowed out in a duel between the Giants and Dodgers.

Note that the last place Colorado Rockies are only 3.5 games back, so it has been a tight start for the entire division.

Carlos Rodon and Adam Wainwright are in the saddle to open this one Sunday. Both look to go deep into the evening. Head below for our free Giants vs. Cardinals prediction on May 15, 2022.

San Francisco Giants vs. St. Louis Cardinals Live Betting Odds:

The following odds are courtesy of Bovada:
Teams Spread Moneyline Total
San Francisco Giants +1.5 (-170) -150 Over 7 (-120)
St. Louis Cardinals +1.5 (-140) +126 Under 7 (+100)
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Team Data San Francisco Giants St. Louis Cardinals
Overall Record 20-13 18-15
Away/Home Record 8-8 10-5
Batting Average .242 .237
Batting Average Away/Home .230 .240
Runs Per 9 5.08 4.44
Team ERA 3.41 3.44
Team ERA Away/Home 2.97 3.65

Giants vs. Cardinals Prediction:

Adam Wainwright is aging like a fine wine that never seems to get worse. He is a 40-year-old who continues to put in work for the Cardinals.

Wainwright finished with an ERA of 3.15 and a 3.05 the past two years. He recorded an ERA of 3.05 and a 1.06 WHIP in 32 starts a season ago.

He’s off to another consistent start and on par with what he accomplished last year. Wainwright has a 3.18 ERA and 1.29 WHIP in six appearances in 2022.

The veteran is coming off a vintage performance against the KC Royals. He conceded just 1 hit and no runs in a 10-0 win on May 4.

His production at home has been in good form, as Wainwright has posted an ERA of 2.25 and a .222 OBA. Yes, Carlos Rodon is pitching well this season, but the oddsmakers aren’t giving Wainwright much respect. He had a very brief stint on the IL, but returns tonight.

San Francisco Giants vs. St. Louis Cardinals Betting Trends:


  • Record (Last 10): 6-4
  • 1-4 overall in their previous five games after a loss
  • 1-4 overall in their previous five games after scoring 2 or fewer runs
  • 3-10 overall in their previous 13 games at St. Louis
  • 8-3 overall in their previous 11 games versus the NL Central
  • 16-5 overall in their previous 21 games on a Sunday


  • Record (Last 10): 5-5
  • 16-5 overall in their previous 21 games versus a left-handed starter
  • 9-4 overall in their previous 13 games versus a team with a winning percentage better than 60%
  • 10-3 overall in their previous 13 games at home versus the Giants
  • 2-5 overall in their previous seven games
  • OVER is 4-1 in their previous five games as an underdog at home

  • Carlos Rodon has been in terrific form this season. He goes into Sunday Night Baseball with a 1.80 ERA and 0.91 WHIP through 5.2 innings per game.

    In his previous two starts, Rodon allowed 9 hits and 4 earned runs through 12 innings for a 3.00 ERA. Rodon has allowed 2 home runs and 4 RBIs versus the Cards in 31 at-bats.

    The Cards have done damage against left-handed pitching this season. They are hitting .255 with a .338 OBP and 6.37 runs per 9 innings.

    Rodon is a strong pitcher, but the oddsmakers appear to be undermining Wainwright just too much.

    St. Louis looks worth a look on Sunday night. The price doesn’t match what it should actually be at Busch Stadium. There looks like value on the Cardinals as home underdogs in this one.


    Giants vs. Cardinals Pick
Kyle E / Author

Kyle is a veteran of TheSportsGeek and has spent nearly a decade providing accurate sports picks and writeups here. He has been a sports handicapper for 10+ years and started sharing his picks and thoughts in 2011 at TheSportsGeek. His expertise spans across multiple sports, including the NFL, NCAAF, MLB, NHL, and horse racing. Prior to writing for TheSportsGeek, Kyle was a fantasy football expert, who ultimately parlayed it into a successful sports betting career. You can find his picks daily only at TheSportsGeek.

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