St. Louis Cardinals vs. Chicago Cubs Pick – MLB June 5, 2022

Sunday Night Baseball is not the New York Mets and Los Angeles Dodgers, with ESPN wishing they probably had a flex option for that game. Instead, we have an NL Central battle between the Chicago Cubs and St. Louis Cardinals.

There’s nothing wrong with the Route 66 Rivalry, but the Mets and Dodgers are two of the best teams in the major leagues. In any event, we should have a fun contest at Wrigley Field, and it’s never a bad setting for a baseball game in Wrigleyville.

The Cardinals are coming off a 7-4 win for their second win in four games at Wrigley Field. They engaged in a doubleheader on Saturday, with the Cubs winning the afternoon matchup, 6-1, and the Cards responding in primetime.

Matt Swarmer had a big performance for the Cubs in the early game. He went 6 innings with 2 hits and 1 earned run allowed. Johan Oviedo was roughed up for 8 hits and 3 earned runs for the Cardinals.

The bats woke up for the Cardinals at night, including a 4-run 10th inning to beat the Cubs in extras.

The Cardinals are in a battle with the Milwaukee Brewers for top honors in the NL Central. They have pulled within 1.5 games of the Brewers after winning five of their last seven outings.

St. Louis is going into tonight at 31-23, while the Cubs are playing to stay out of the basement of the division at 23-31. They have a four-game advantage on the Cincinnati Reds, but that’s their only accomplishment to note.

They’ve been in better shape recently with four wins in six games. With a rotation that features a struggling Justin Steele, it’s easy to see where they losses are coming from. The pitching staff must be better.

Steele is in his first full season in the starting rotation after 20 appearances last year, with nine starts as a rookie. He is looking to improve this afternoon after a shaky start to the 2022 campaign.

40-year-old veteran Adam Wainwright, who looks like he has five more years in him, is countering for the Cards at Wrigley Field. Head below for our best Cardinals vs. Cubs pick on June 5, 2022.

St. Louis Cardinals vs. Chicago Cubs Live Betting Odds:

The following odds are courtesy of Bovada:
Teams Spread Moneyline Total
St. Louis Cardinals -1.5 (+120) -140 Over 8.5 (-120)
Chicago Cubs +1.5 (-140) +117 Under 8.5 (+100)
Betting Site
Bonus Bet Now
1BetOnline Logo BetOnline
50% up to $1,000 Go to Site
2 BetUS
125% up to $2,500 Go to Site
3 Everygame
100% up to $500 Go to Site
4 Bovada
50% up to $1,000 Go to Site
100% up to $1,000 Go to Site
6 MyBookie
100% up to $1,000 Go to Site
Team Data St. Louis Cardinals Chicago Cubs
Overall Record 31-23 23-31
Away/Home Record 15-12 11-19
Batting Average .251 .242
Batting Average Away/Home .256 .248
Runs Per 9 5.00 4.55
Team ERA 3.82 4.35
Team ERA Away/Home 3.90 4.13

Cardinals vs. Cubs Prediction:

Adam Wainwright isn’t getting any younger, but his arm appears to have found the fountain of youth. Wainwright is going into Wrigley Field in good form.

He has an ERA of 2.75 and a 1.19 WHIP through 59 innings. Wainwright has a 1.89 ERA and 1.11 WHIP in his previous three starts. He was toughed up for 10 hits and 3 earned runs against the Brewers, but bounced back versus the Padres in a 3-2 win.

In his latest performance, Wainwright allowed 2 hits and no runs at Busch Stadium. He is less effective on the road, but still solid enough.

Wainwright owns an ERA of 3.10 and a 1.28 WHIP as opposed to a 2.40 ERA and 1.10 WHIP at home. However, the Cubs have a good history of scoring runs against him.

This Cubs lineup has hit 7 long balls and 20 RBIs versus Wainwright in 121 at-bats.

In his lengthy history at Wrigley Field, the Cubs are hitting .269 against Wainwright in 547 at-bats. They may not do huge damage, but enough to give Justin Steele a chance.

St. Louis Cardinals vs. Chicago Cubs Betting Trends:


  • Record (Last 10): 7-3
  • 40-18 overall in their previous 58 games as a betting favorite
  • 19-7 overall in their previous versus a left-handed starter
  • OVER is 4-0-1 in their previous five games as a betting favorite on th eroad
  • OVER is 5-1 in their previous six games versus the NL Central
  • OVER is 4-1-1 in their previous six games versus a team with a losing record


  • Record (Last 10): 5-5
  • 5-0 overall in their previous five fifth game of a series
  • 4-1 overall in their previous five games versus the NL Central
  • OVER is 4-1 in their previous five games as an underdog
  • OVER is 8-3 in their previous 11 games at home
  • OVER is 12-4-1 in their previous 17 games at home versus a team with a winning record

  • Steele is likely going to need run support to leave tonight with a win. He isn’t having a season that he envisioned in his second season and first full-time role in the rotation.

    Steele is going into this Sunday Night Baseball with an ERA of 5.40 and a 1.58 WHIP.

    He wrapped up his first campaign in the majors with a 4.26 ERA and 1.35 WHIP. Steele was looking for better after that acceptable start to his career.

    Steele has gotten walloped for an ERA of 7.50 and a 1.58 WHIP in his previous three starts this season. He allowed 10 earned runs in 7 innings of work.

    The Cards are an underrated offense this season. They are fourth with 5 runs per 9 innings and a batting average of .254. The Cubs are ninth in the majors, with an average of 4.55 runs per 9 frames for ninth.

    This looks like a stop where the total is a half run too short. While I like Wainright, he typically doesn’t go through this team without any blemishes. I’m going with the OVER in a 6-5 or 5-4 game at Wrigley Field.


    Cardinals vs. Cubs Pick
    OVER 8.5
Kyle E / Author

Kyle is a veteran of TheSportsGeek and has spent nearly a decade providing accurate sports picks and writeups here. He has been a sports handicapper for 10+ years and started sharing his picks and thoughts in 2011 at TheSportsGeek. His expertise spans across multiple sports, including the NFL, NCAAF, MLB, NHL, and horse racing. Prior to writing for TheSportsGeek, Kyle was a fantasy football expert, who ultimately parlayed it into a successful sports betting career. You can find his picks daily only at TheSportsGeek.

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.