St. Louis Cardinals vs. San Francisco Giants Pick – MLB May 5, 2022

The St. Louis Cardinals and San Francisco Giants are on the diamond at Oracle Park for the first of a four-game series in the Bay Area. The Giants are coming off a tough 9-1 loss to the LA Dodgers on Wednesday night.

Alex Wood wasn’t that bad, as he made it through 5.1 innings with 3 earned runs allowed. However, the bullpen ran into problems, as they allowed 6 earned runs to take the Giants out of the game.

The Giants typically can’t win games like this. They are far better off when the pitching staff is in good form and winning 3-1 and 4-2 kinds of games. That’s when the Giants are at their best.

The Giants head into Thursday night with a record of 14-10 and 2.5 games behind the LA Dodgers for the lead in the NL West.

The Dodgers beat the Giants in two of two games for a sweep at Dodger Stadium. It was a brief two-game tilt to get the juices flowing between these two hated fanbases. The Giants go back home to welcome the Cardinals at Oracle Park.

St. Louis is going into this one even with the Giants at 14-10 on the season. The Cards are coming off a 10-0 win over the Kansas City Royals yesterday. They were coming off a 7-1 loss in the first game and changed their rune the next day.

The Cardinals have been very much up and down recently, as they enter the Bay Area with a loss in three of their previous five attempts. The last time they met the Giants, they won back-to-back games at home, 3-1 and 2-1 last July.

Miles Mikolas and Mauricio Llovera are scheduled to get the starting jobs on the mound tonight.

Mikolas has been in Cy Young form to open the season and will look to stay hot in San Francisco. Llovera will open this one in a bullpen game for the Giants.

Head below for our free Cardinals vs. Giants prediction on May 5, 2022.

St. Louis Cardinals vs. San Francisco Giants Live Betting Odds:

The following odds are courtesy of Bovada:
Teams Spread Moneyline Total
St. Louis Cardinals +1.5 (-210) -102 Over 7.5 (+105)
San Francisco Giants -1.5 (+175) -118 Under 7.5 (-125)
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Team Data St. Louis Cardinals San Francisco Giants
Overall Record 14-10 14-10
Away/Home Record 7-5 6-5
Batting Average .231 .231
Batting Average Away/Home .224 .234
Runs Per 9 4.26 4.79
Team ERA 3.20 3.33
Team ERA Away/Home 2.62 3.78

Cardinals vs. Giants Prediction:

It’s too early to suggest Cy Young candidates, but Miles Mikolas is pitching like a guy that wants to win the coveted award in the National League. He has been one of the best in the National League, and certainly the most underrated hurler in 2022.

Mikolas is going into Thursday night hot through his first five starts. He hasn’t looked bad in any of his appearances and should stay in good form in the Bay Area.

Mikolas is going into this contest with an ERA of 1.52 and a 0.84 WHIP in five games. His best effort has come on the road, where Mikolas has recorded an ERA of 0.77 and a 0.69 WHIP in 13.1 innings on the bump.

In his most impressive start, Mikolas held the Brewers to 3 hits and 1 earned run across 6.2 innings at Milwaukee.

Mikolas’ worst outing was his season opener versus the Pittsburgh Pirates on April 9. He was tagged for 6 hits and 2 earned runs in 3.2 innings. However, since then, Miokolas has been untouchable.

Mikolas posted an ERA of 0.93 and a 0.67 WHIP in his previous three starts. He gave up only 2 runs in 21.1 innings on the hill. The Giants are hitting just .191 versus Mikolas in 111 at-bats.

St. Louis Cardinals vs. San Francisco Giants Betting Trends:


  • Record (Last 10): 4-6
  • 10-4 overall in their previous 14 games as an underdog
  • 12-3 overall in their previous 15 games in the first game of a series
  • UNDER is 4-1 in their previous five games as an underdog on the road
  • UNDER is 6-2 in their previous eight games on the road
  • UNDER is 5-1 in their previous six games after their opponent conceded 5 or more runs


  • Record (Last 10): 5-5
  • 5-0 overall in their previous five games versus the NL Central
  • 43-14 overall in their previous 57 games as a betting favorite
  • 2-5 overall in their previous seven games versus the Cardinals
  • UNDER is 4-1 in their previous five games after conceding 5 or more runs
  • UNDER is 8-2 in their previous ten games after their opponent concedes 5 or more runs

The Giants’ bullpen did not hold up well last night, but should bounce back at home. That wasn’t like the Giants’ pitching staff. Note that San Franciso ranks as one of the better bullpens in the major leagues.

San Francisco has an ERA of 3.09 and a 1.19 WHIP from their bullpen. They rank in the top-10 in the majors despite struggling to get into a groove last night.

It’s unlikely that the Giants are going to look bad on the bump in consecutive games, especially at Oracle Park in San Francisco. Mikolas has been in the zone and could be tough for the offense, though. Look for the UNDER to be the best bet in this one in the Bay Area.


Cardinals vs. Giants Pick
Kyle E / Author

Kyle is a veteran of TheSportsGeek and has spent nearly a decade providing accurate sports picks and writeups here. He has been a sports handicapper for 10+ years and started sharing his picks and thoughts in 2011 at TheSportsGeek. His expertise spans across multiple sports, including the NFL, NCAAF, MLB, NHL, and horse racing. Prior to writing for TheSportsGeek, Kyle was a fantasy football expert, who ultimately parlayed it into a successful sports betting career. You can find his picks daily only at TheSportsGeek.

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