St. Louis Cardinals vs. San Francisco Giants Pick – MLB May 6, 2022

The St. Louis Cardinals and San Francisco Giants are back at Oracle Park in the Bay Area on Friday night. It was all Cardinals last night, as they cleared on the road for a 7-1 win over the Giants.

Miles Mikolas was in top form again, as he allowed 1 earned run across 5.2 innings of work. Mikolas had to work out of some jams, but held strong and turned in another solid performance. The Cardinals made it back-to-back stellar outings.

St. Louis was coming off a 10-0 win over the Kansas City Royals. It’s been close to perfect for the Cardinals in their previous two attempts.

The Cardinals are going into Friday night with a record of 15-10 after responding nicely following a 7-1 loss in Kansas City on Tuesday.

San Francisco is a small rut after their third straight loss last night. They’ve also lost six of seven outings going into Friday.

San Francisco is 14-11 and three games behind the LA Dodgers in the NL West. They were in a dead heat with the Dodgers last year in the divisional race, with a one-game advantage to capture the NL West crown.

Head below for our free Cardinals vs. Giants prediction on May 6, 2022.

St. Louis Cardinals vs. San Francisco Giants Live Betting Odds:

The following odds are courtesy of Bovada:
Teams Spread Moneyline Total
St. Louis Cardinals +1.5 (-200) +117 Over 7 (-120)
San Francisco Giants -1.5 (+170) -140 Under 7 (+100)
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Team Data St. Louis Cardinals San Francisco Giants
Overall Record 15-10 14-11
Away/Home Record 8-5 6-6
Batting Average .235 .234
Batting Average Away/Home .232 .239
Runs Per 9 4.46 4.55
Team ERA 3.11 3.49
Team ERA Away/Home 3.03 3.48

Cardinals vs. Giants Prediction:

The Cardinals will look to stay hot with Jordan Hicks on the bump at Oracle Park tonight. Hicks has been more of an opener than a true starter this season.

The most work he’s received is 3.1 innings in his most recent attempt against the Arizona Cardinals in a 7-5 win. Hicks allowed 2 hits and 2 earned runs. He gave up two home runs for the first long balls he’s conceded in 2022.

It was the second straight start that Hicks gave up 2 earned runs while he was on the bump. Overall, Hicks has an ERA of 3.65 and a 1.22 WHIP across 13 innings. Hicks has a 5.40 ERA and 1.44 WHIP in his previous three starts.

Opponents have notched a .361 OBP versus Hicks across his last 9 innings on the bump. The bullpen will do most of the heavy lifting in San Francisco tonight.

The St. Louis bullpen has an ERA of 3.10 and a 1.15 WHIP entering Friday night at Oracle Park. We’ll see what state this game is in after Hicks exits the game.

Alex Cobb is looking for better success after coming off a horrendous performance versus the Washington Nationals.

This hasn’t been a good start for Cobb with his new team. Cobb joined the Giants after posting an ERA of 3.76 and a 1.26 WHIP with the Angels last year.

St. Louis Cardinals vs. San Francisco Giants Betting Trends:


  • Record (Last 10): 5-5
  • 14-4 overall in their previous 18 games versus a right-handed starter
  • 11-4 overall in their previous 15 games as an underdog on the road
  • 21-6 overall in their previous 27 games after scoring 5 or more runs
  • OVER is 4-1 in their previous five games
  • OVER is 4-1 in their previous five games versus the NL West


  • Record (Last 10): 4-6
  • 5-1 overall in their previous six games versus the NL Central
  • 46-16 overall in their previous 62 games as a betting favorite
  • OVER is 4-0 in their previous four games as a betting favorite at home
  • OVER is 5-1 in their previous six games
  • OVER is 4-0 in their previous four games versus a right-handed starter

Cobb is going into this matchup with an ERA of 5.40 and a 1.90 WHIP through 10 innings on the bump. He’s been all over the place and hasn’t found much consistency.

Cobb has an ERA of 4.76 and a 2.29 WHIP at home this season. Batters have recorded a .419 OBP against Cobb at Oracle Park.

Last year, he rejuvenated his career after failing to finish with an ERA below 4.00 in three straight seasons. However, Cobb appears to be heading in the wrong direction again.

The Cards have liked hitting against Cobb, as they have a team batting average of .322 and a .544 OBP in 20 at-bats.

In only 20 at-bats, the Cardinals have hit Cobb for 2 home runs and 5 RBIs. The Cards have been hot at the plate as of late, too, with at least 7 runs scored in three of their previous three outings.

Overall, the Cardinals are 12th in the major leagues with 4.42 runs scored per 9 innings, while the Giants are 10th with 4.53 runs per 9 innings. The Cards and Giants are both in the top half of the majors in batting average.

The OVER at 7 runs looks like the best place to look at Oracle Park. This looks a tad too short in a total that should probably be at 8 runs.


Cardinals vs. Giants Pick
Kyle E / Author

Kyle is a veteran of TheSportsGeek and has spent nearly a decade providing accurate sports picks and writeups here. He has been a sports handicapper for 10+ years and started sharing his picks and thoughts in 2011 at TheSportsGeek. His expertise spans across multiple sports, including the NFL, NCAAF, MLB, NHL, and horse racing. Prior to writing for TheSportsGeek, Kyle was a fantasy football expert, who ultimately parlayed it into a successful sports betting career. You can find his picks daily only at TheSportsGeek.

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