St. Louis Cardinals vs. Washington Nationals Pick – MLB July 29, 2022

The St. Louis Cardinals and Washington Nationals open a three-game series at Nationals Park on Friday night. Washington had the day off following a 7-1 loss to the LA Dodgers on Thursday afternoon.

The Nats had a chance to sweep the Dodgers, but were left well short at Dodger Stadium. Despite the loss, the Nationals were still able to pick up a rare series win against a World Series contender.

The Nationals were the last team to win the World Series before Covid-19 hit and we had a shortened campaign in 2020. It’s crazy to think that it was only three years back that the Nats won the World Series.

Three years later, the Nationals are 34-66 and 28 games behind the New York Mets for the lead in the NL East. They’re going home with a series win over the Dodgers, but you wouldn’t know it by looking at the standings.

The Cards are in the midst of a divisional race with the Milwaukee Brewers.

They can’t afford to pass up too many winnable games down the stretch. The Nationals are an opponent where the Cardinals have to complete the layup if they want to bypass the Brewers.

St. Louis is 52-47 and coming off two of three losses. They took a split at the Rogers Centre without Paul Goldschmidt and Nolan Arenado in the lineup.

Goldschmidt and Arenado were unable to play in Canada because of their vaccination status. Expect both back in the lineup and they should be fresh at Nationals Park. Head below for our free Cardinals vs. Nationals prediction on July 29, 2022.

St. Louis Cardinals vs. Washington Nationals Live Betting Odds:

MLB Odds Courtesy of Bovada:
Team Spread Moneyline Total
St. Louis Cardinals -1.5 (-115) -180 Over 9 (+100)
Washington Nationals +1.5 (-105) +148 Under 9 (-120)
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Team Data St. Louis Cardinals Washington Nationals
Overall Record 52-47 34-66
Away/Home Record 23-27 15-36
Batting Average .252 .247
Batting Average Away/Home .247 .236
Runs Per 9 4.67 3.94
Team ERA 3.87 5.13
Team ERA Away/Home 4.33 4.65

Cardinals vs. Nationals Prediction:

Veteran Anibal Sanchez made his debut this season on July 14. He was slow out of the gate with a 7.20 ERA in 5 innings against the Braves.

Sanchez struggled with 4 hits and 4 earned runs, which includes 2 home runs and 2 walks.

He didn’t settle down in his next and most recent performance last week against the Arizona Diamondbacks. Sanchez gave up 6 hits and 3 earned runs through 5 innings of work.

Sanchez looked like he was going to drop out of the majors after 2017. He had a 6.41 ERA and 1.59 WHIP in his final season with the Tigers.

However, Sanchez didn’t flame out and he was a contributor for the Braves in 2018 and then did well the following season with the Nationals. Since then, though, he looks like the same pitcher as he did in his remaining years in Detroit.

Sanchez needs a big bounce-back spot, but the Cardinals likely aren’t that team.

Goldschmidt and Arenado returning should give the Cards a big lift at the plate. St. Louis is ninth in the majors with a .252 batting average and 4.67 runs per 9 innings.

St. Louis Cardinals vs. Washington Nationals Betting Trends:


  • Record (Last 10): 5-5
  • 5-2 overall in their previous seven games after conceding 2 runs or fewer
  • 3-7 overall in their previous ten games on the road
  • 1-5 overall in their previous six games on a Friday
  • OVER is 4-1 in their previous five games
  • OVER is 5-2 in their previous seven games versus a right-handed starter


  • Record (Last 10): 4-6
  • 5-11 overall in their previous 16 games after a day off
  • 1-10 overall in thier previous 11 games at home
  • OVER is 5-2 in their previous seven games versus a right-handed starter
  • OVER is 10-4 in their previous 14 games versus a team with a winning record
  • OVER is 6-3 in their previous nine games on a Friday

  • The Cardinals are likely to do damage against Sanchez in this one. Sanchez has allowed 10 RBIs and 3 home runs to the Cardinals in 70 at-bats.

    Miles Mikolas is coming off a poor performance at Busch Stadium.

    Mikolas was never in control, as he allowed 7 hits and 6 earned runs through 5 innings of work. It’s a rare bad spot for Mikolas at home, where he owns a 2.31 ERA and 0.83 WHIP.

    He’s fine, but less effective on the road with an ERA of 3.51 and a 1.17 WHIP. Spotty rain is expected, so Mikolas may not be on the mound long anyway.

    Sanchez isn’t expected to pitch well, and if the ball goes over to the bullpen early, this isn’t good news either. The Nats have a bullpen ERA of 4.24 with a 1.33 WHIP. I’m looking at the OVER. The total looks a half-point too short.


    Cardinals vs. Nationals Pick
    OVER 9
Kyle E / Author

Kyle is a veteran of TheSportsGeek and has spent nearly a decade providing accurate sports picks and writeups here. He has been a sports handicapper for 10+ years and started sharing his picks and thoughts in 2011 at TheSportsGeek. His expertise spans across multiple sports, including the NFL, NCAAF, MLB, NHL, and horse racing. Prior to writing for TheSportsGeek, Kyle was a fantasy football expert, who ultimately parlayed it into a successful sports betting career. You can find his picks daily only at TheSportsGeek.

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