Toronto Blue Jays vs. St. Louis Cardinals Pick – MLB May 23, 2022

The Toronto Blue Jays and St. Louis Cardinals have a short two-game interleague series at Busch Stadium over the next two days. The Jays are coming off a 3-2 loss to the Cincinnati Reds on Sunday afternoon.

However, they had a win in two of three games, 2-1 and 3-1. There wasn’t too much action at the plate for Toronto in that series. The offense didn’t look at its best against the Seattle Mariners, either.

There is too much talent in the Blue Jays lineup for them to struggle consistently offensively. If I were a Jays fan, I wouldn’t be too concerned with the lack of offense.

I would feel good about where the pitching staff is at now, though. They’ve held up well and were the reason for two of three wins over the weekend. Long-term, this season, the Jays need Hyun-jin Ryu and Jose Berrios to be good consistently.

Alek Manoah looks like a stud, so Ryu and Berrios earning their big paydays, the Jays have those three along with Kevin Gausman.

On paper, this is a really good rotation. Ryu hasn’t been at his best, but he responded well in his last start with 6 innings of scoreless baseball on Friday. Manoah followed up with 8 innings with 1 earned run allowed in a 3-1 win Saturday.

Yusei Kikuchi did his part yesterday as well, though this was a game where they needed a clutch hit and didn’t get it. Berrios is up next in the rotation.

Miles Mikolas is scheduled to start for the Cardinals, so Berrios may have to be in perfect form. Mikolas has been in the best form of his career through eight starts.

Berrios and Mikolas get this interleague started at Busch Stadium in St. Louis tonight. It should be a good one. Head below for our free Blue Jays vs. Cardinals prediction on May 23, 2022.

Toronto Blue Jays vs. St. Louis Cardinals Live Betting Odds:

The following odds are courtesy of Bovada:
Teams Spread Moneyline Total
Toronto Blue Jays +1.5 (-200) +103 Over 7.5 (-105)
St. Louis Cardinals -1.5 (+170) -123 Under 7.5 (-115)
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Team Data Toronto Blue Jays St. Louis Cardinals
Overall Record 22-19 23-18
Away/Home Record 8-11 10-8
Batting Average .230 .253
Batting Average Away/Home .217 .252
Runs Per 9 3.70 5.00
Team ERA 3.59 3.70
Team ERA Away/Home 3.40 3.78

Blue Jays vs. Cardinals Prediction:

Jose Berrios signed a nice seven-year extension worth $131 million in the offseason. He was involved in a trade to the Blue Jays from the Twins and found a new home in Toronto for the foreseeable future.

We’ve seen just about everything from Berrios this season. He has looked flawless, like in his most recent start against Seattle Mariners. Berrios didn’t give up a run across 7 innings of work.

However, there’s been bad Berrios as well. Before settling down, he gave up 11 earned runs in 10 innings against the Guardians and Yankees. In his previous three starts, Berrios is going into tonight with an ERA of 5.82 and a 1.35 WHIP.

Overall, Berrios owns an ERA of 4.83 and a 1.49 WHIP.

His production has been worse on the road, where Berrios has an ERA of 6.43 and a 1.57 WHIP. He will have to do much better with the Toronto offense fizzling and Mikolas on the other side. The Cards are hitting .267 with 5 RBIs versus Berrios in 32 at-bats.

Toronto Blue Jays vs. St. Louis Cardinals Betting Trends:

Blue Jays

  • Record (Last 10): 5-5
  • 1-5 overall in their previous six games as an underdog on the road
  • 1-6 overall in their previous seven games on the road
  • 4-14 overall in their previous 18 games versus a team with a winning record
  • 1-4 overall in their previous five games on the road versus the National League
  • 2-5 overall in their previous seven games in the first game of a series


  • Record (Last 10): 6-4
  • 11-5 overall in their previous 16 games versus the American League
  • 10-4 overall in their previous 14 games versus a team with a winning record
  • 14-6 overall in their previous 20 games in the first game of a series
  • 4-1 overall in their previous five games versus the Blue Jays
  • OVER is 8-1 in their previous nine games versus the Cardinals at home

  • Mikolas is in Cy Young form over the first Q1 of the season. He brings an ERA of 1.68 and a 0.99 WHIP into tonight.

    Mikolas has allowed 2 or fewer earned runs in all eight starts this season.

    In 25 innings in St. Louis at Busch Stadium, Mikolas has allowed 5 runs in 18 innings for a 1.80 ERA.

    The Cardinals are hot at the plate to open this season. They’ve been incredibly underrated with 5 runs per 9 innings for the third-best offense in the majors and second with a team batting average of .256.

    At Busch Stadium, the Cards have been in good form with 5.23 runs scored per 9 innings. Conversely, the Jays have been disappointing with 3.45 runs per 9 on .217 hitting.

    Mikolas has not been a starter to go against this year. He’s locked in and worth a look at this level at home. Consider the Cardinals to win on the moneyline.


    Blue Jays vs. Cardinals Pick
Kyle E / Author

Kyle is a veteran of TheSportsGeek and has spent nearly a decade providing accurate sports picks and writeups here. He has been a sports handicapper for 10+ years and started sharing his picks and thoughts in 2011 at TheSportsGeek. His expertise spans across multiple sports, including the NFL, NCAAF, MLB, NHL, and horse racing. Prior to writing for TheSportsGeek, Kyle was a fantasy football expert, who ultimately parlayed it into a successful sports betting career. You can find his picks daily only at TheSportsGeek.

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