San Francisco (4-5) at New Orleans (6-2)
Old NFC West rivals renew pleasantries as San Francisco has a 48-26-2 lead in a series that started in 1967. New Orleans has won eight of the last 12 going back to 2002 but lost the last meeting in a 48-46 shutout in the Mercedes-Benz Superdome last December. 49ers quarterback Jimmy Garropolo threw four touchdown passes in that win as both teams combined for 965 total yards.
The Saints are one of the hottest teams in the NFL as they have won four in a row after back-to-back losses to the Raiders and Packers in Week 2 and Week 3. Wide receiver Michael Thomas looks for his third straight game where he posts at least five catches and a touchdown reception.
The 49ers have lost two games in a row and four out of their last six as they have a litany of injuries that touches all three phases of the game. Running back Raheem Mostert has six touchdowns in his last four road games, so he is looking to extend the streak to five in a row with a touchdown.
Vs. The Spread
The 49ers are 2-4 ATS and SU in their last six games while they are 5-1-1 ATS in their last seven games against New Orleans. The total has gone under in 13 of the 49ers’ last 20 games at New Orleans. The Saints are 1-5 ATS in their last six games, where they are favored.
|Teams||Spread||Money Line||Total Points|
|San Francisco 49ers||+10 (-125)||+345||O 49 (-115)|
|New Orleans Saints||-10 (+105)||-425||U 49 (-105)|
Nick Mullens threw for 291 yards, but most of this was in soft zone time after Green Bay rolled up a 34-3 lead going into the fourth quarter of last week’s 34-17 win at San Francisco. Injuries and Covid-19 issues left the Niners in a beleaguered position in falling to 4-5.
New Orleans potentially played the best total 60 minutes of any NFL team this season as the Saints mashed the Buccaneers, 38-3, in Tampa Bay. The Saints picked off Tom Brady three times and rushed to a 28-0 lead in the second quarter as Drew Brees threw four touchdown passes on the evening.
Wide receiver Richie James came on the scene in a big way last week with nine catches for 184 yards and a score. Wide receiver Brandon Aiyuk had 17 catches for 206 yards in the two prior games and was sidelined with an injury last week. It’s Nick Mullen’s ship to sail with Garoppolo on IR. He will face a Saints pass rush that was repeatedly in Brady’s face on Sunday night.
The Saints have their swag back with the four-game winning streak as Alvin Kamara continues to lead the NFL as he has 1,036 yards from scrimmage through eight games. Wide receivers Michael Thomas, Emmanuel Sanders, and tight end Jared Cook all had big days in last season’s shootout. Thomas is almost a given for a big game with at least 10 receptions and 100 yards in six of his last seven at home.
NFL Betting Predictions
Winner: New Orleans (-10) 35, San Francisco 20
Over-Under: Take Over 49