San Francisco 49ers vs Arizona Cardinals NFL Pick – Week 5

The NFL is set up with another great slate of football on October 10. Fourteen games are up on the board throughout Sunday. One of these games will be between the San Francisco 49ers and the Arizona Cardinals. These two teams have been solid throughout this season and will look for a huge win in this one. This game will kick off at around 4:25 PM Eastern time.

San Francisco has earned a record of 2-2 throughout this season, which has them in last place of the NFC West. The 49ers met up with the Seattle Seahawks in Week 4. Russell Wilson had two passing touchdowns and a rushing touchdown on the afternoon. The Seahawks were able to hold off Trey Lance to earn a 28-21 win.

The Cardinals have posted a record of 4-4 on the season, which has them in the top spot of the NFC West. Arizona is the last remaining undefeated team and will look for a big win in this one. The Cardinals are coming off a huge win against the Los Angeles Rams. Kyler Murray had two passing touchdowns and James Conner had two rushing touchdowns. Arizona earned a big 37-20 win in this one to stay perfect.

These two teams have been solid throughout this season and will look for a huge win in this divisional matchup. The 49ers are coming off a tough loss in Week 4, while Arizona pulled off a huge road upset. Now San Francisco will look to hand the Cardinals their first loss of the season. If either team can come out quickly in this one, it could be enough for the win.

49ers vs. Cardinals Live Odds and Betting History

The following odds are courtesy of BetOnline:

Teams Spread Money Line Totals
San Francisco 49ers +5 (-110) +190 Over 49 ½ (-112)
Arizona Cardinals -5 (-110) -220 Under 49 ½ (-108)
Betting Data San Francisco 49ers Arizona Cardinals
2021 Record 2-2 4-0
2021 Home 0-2 1-0
2021 Away 2-0 3-0
2021 ATS 2-2 3-1
2021 ATS Home 0-2 0-1
2021 ATS Away 2-0 3-0
2021 O/U 2-2 2-2
2021 O/U Home 1-1 1-0
2021 O/U Away 1-1 1-2

49ers vs. Cardinals NFL Game Preview

These two teams met up twice throughout last season. The first meeting was in San Francisco in Week 1 last season. Kyler Murray had a passing touchdown and a rushing touchdown as the Cardinals earned a 24-20 win. C.J. Beathard threw for three passing touchdowns in the second meeting as the 49ers earned a 20-12 win in Week 16.

The 49ers and Cardinals have met up 59 times throughout their histories. San Francisco leads the all-time series with a record of 32-27. The 49ers have also won three of their last four games against Arizona. The Cardinals have jumped out to a strong start this season though and will look to knock off San Francisco on Sunday

These two teams look very similar to last season. San Francisco could have Jimmy Garoppolo back after he went down with injury in Week 4. Trey Lance could get the start though if Garoppolo isn’t ready. Kyler Murray has been on a hot streak to open up this season and will look to keep it going in this one. Both defenses have looked solid as well early in this season.

Opening Odds and Line Movement

The spread for this game started out at -2 ½ in favor of the Arizona Cardinals. The line got up as big as -5 ½ during the week, but has since dropped back down to -5 points.

The over/under for this one opened up at 52 ½ points. The total for this game dropped down to 49 ½ points as well. This total makes sense as both teams have shown some strong offenses throughout this season.

The spread in this one has only gotten bigger in favor of the Cardinals, which makes sense after their big win against the Los Angeles Rams last week. San Francisco will look to bounce back with a win in this one.

Head to Head Betting Trends

  • Cardinals 7-3 SU in last 10 games
  • Cardinals 6-4 ATS in last 10 matchups
  • Under is 6-4 in last 10 meetings
  • Under is 4-1 in last five games in Arizona

San Francisco 49ers Betting Trends

  • 23-16 SU in last 39 games
  • 19-19-1 ATS in last 39 games
  • 7-6 SU in last 13 games as an underdog
  • 9-4 ATS in last 13 games as an underdog
  • 14-4 SU in last 18 road games
  • 12-6 ATS in last 18 road games
  • 8-5 SU in last 13 division games
  • 6-6-1 ATS in last 13 division games
  • 4-1 SU in last five dome games
  • 2-3 ATS in last five dome games
  • 7-3 SU in last 10 October games
  • 5-5 ATS in last 10 October games

Arizona Cardinals Betting Trends

  • 17-18-1 SU in last 36 games
  • 18-17-1 ATS in last 36 games
  • 7-7 SU in last 14 games as favorite
  • 4-10 ATS in last 14 games as favorite
  • 7-9-1 SU in last 17 home games
  • 6-11 ATS in last 17 home games
  • 4-9 SU in last 13 division games
  • 5-7-1 ATS in last 13 division games
  • 7-10-1 SU in last 18 dome games
  • 6-12 ATS in last 18 dome games
  • 7-3 SU in last 10 October games
  • 8-2 ATS in last 10 October games

Free Bet and Game Prediction: San Francisco 49ers +5 (-110)

These two teams have been solid early in this season and will look for a big win in this one. San Francisco kept it close last week when Lance had to step in midway through the game. Now with a full week of practice for Lance, it could be enough to help the 49ers pull off the upset. If either team can come out quickly in this one, it could be enough for the win.

Kyler Murray will start under center for Arizona in this one. Murray has thrown for 1273 yards, nine touchdowns and four interceptions. He has also rushed for 109 yards and three touchdowns. Trey Lance has passed for 162 yards and three touchdowns in his limited snaps this season. He has also rushed for 44 yards and a touchdown.

This spread is listed at -5 against the spread in favor of the Cardinals. This line makes sense with Arizona being undefeated and looking almost unbeatable. Trey Lance has looked solid though and with a week of practice, I think he can put up a strong performance in this one. Five points is a pretty big spread for a divisional game, which gives really good value to the 49ers.

The Bet
San Francisco 49ers +5
-110

49ers vs. Cardinals Betting Recap:

  • Oddmaker: BetOnline
  • Money Lines: San Francisco 49ers (+190) vs. Arizona Cardinals (-220)
  • Spread: Cardinals -5 (-110)
  • Over/Under: 49 ½ Points
  • Prediction: 49ers 23 – Cardinals 27
Andruw Burling / Author

Andruw Burling has been writing sports picks since 2017, covering mainly NHL and NBA content, but doing work in other sports as well. Andruw grew up in Las Vegas and has been around sports since a young age. He grew up a huge NHL and NBA fan and continues to use that knowledge in his content today.

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