Seattle Seahawks vs. San Francisco 49ers Pick – NFL Week 4

The rivalry is reunited in the Bay Area between the Seattle Seahawks and San Francisco 49ers. The Seahawks and 49ers are scheduled to dance at Levi’s Stadium on Saturday afternoon on the west coast. This should be a good one with both teams coming off losses this past week.

The 49ers had a tougher pill to swallow, as they thought they had a win in the bag after scoring a winning touchdown with seconds remaining in the game. Jimmy Garoppolo led the 49ers downfield to score a touchdown to take a 28-27 lead.

Not so fast said Aaron Rodgers, as he directed a not so surprising drive to set up a Mason Crosby field goal for the win. It felt like the 49ers left too much time on the clock for Rodgers to operate. He made good on the chance to steal one on the road in San Francisco.

The Seahawks didn’t have as much of a punch to the gut, but they thought things were going swimmingly after scoring 10 quick points in the 1st quarter. After going into the break at 21-17, the Seahawks didn’t score another point. The Vikings shut the Seahawks out and were rewarded with a 30-17 win.

Seattle must have forgotten that there was a second-half to play because everyone looked disinterested, including Russell Wilson. Could they have been looking ahead to the 49ers this week? It’s a game that the Seahawks surely had circled going into this season.

In their most recent meeting, the Seahawks were 26-23 winners in Week 17. It was their second straight win, which included a 37-27 win earlier in the year. The Seahawks have beaten the 49ers in three of their last four meetings. Head below for our free Seahawks vs. 49ers pick on October 3, 2021.

Seattle Seahawks vs. San Francisco 49ers Live Odds and Betting History:

The following odds are courtesy of BetUS:

Teams Spread Moneyline Total
Seattle Seahawks +2.5 (-110) +115 Over 52 (-110)
San Francisco 49ers -2.5 (-110) -135 Under 52 (-110)
Team Data Seattle Seahawks San Francisco 49ers
Overall Record 1-2 2-1
ATS Record 1-2-0 1-2-0
Away/Home Record 1-1 0-1
ATS Away/Home 1-1-0 0-1-0
Points Per Game 25 28.7
Points Against Per Game 26.3 24.7
Passing Yards Per Game 243.7 281.3
Rushing Yards Per Game 107.7 105

Seahawks vs. 49ers Prediction:

The offense completely went silent for the Seahawks after trading points with the Vikings last week. They went from going up and down the field with ease, and then the Vikings’ defense was able to counter impressively thereafter. It was like somebody threw some cold water on the Seahawks.

Russell Wilson finished the game with a decent statline, with 298 yards, 1 touchdown, and no interceptions. DK Metcalf showed up with 6 receptions for 107 yards and a touchdown. He and Tyler Lockett continue to trade big games.

Whoever has the hot hand and favorable matchup, Wilson will be looking their way. After they went cold in the second-half, I can see the Seahawks coming out firing in San Francisco. This is a 49ers’ defense that the Seahawks have been successful against with 63 points in the regular season.

Wilson has passed for 32 touchdowns and 9 interceptions on 63.3% passing against the 49ers in his career. He’s had to deal with much tougher Niners’ defenses earlier in his career. They aren’t the worst, but lag behind where they were a Super Bowl team with Jim Harbaugh.

Seattle Seahawks vs. San Francisco 49ers Betting Trends:


  • 9-3 ATS in in their previous 12 games as an underdog on the road
  • 11-4 ATS in their previous 15 games as an underdog
  • 1-4 ATS in their previous five games
  • 1-4 ATS in their previous five games in October
  • 1-7 ATS in their previous eight games on the road
  • OVER is 9-3-1 in their previous 14 games as an underdog


  • 4-1 ATS in their previous five games versus the NFC West
  • 10-26-1 ATS in their previous 37 games as a favorite
  • 1-4 ATS in their previous five games versus a team with a losing record
  • 5-27-1 ATS in their previous 27 games as a home favorite
  • OVER is 4-1 in their previous five games at Levi’s Stadium

The 49ers have conceded 370.3 yards and 24.7 points per game for 16th in the NFL. If the defense isn’t in prime form on Sunday, the offense should still be able to move the ball on a defense that has tanked since the peak of this rivalry.

Seattle has been on a downslope defensively since losing to the Patriots in the Super Bowl. They’ve been one of the worst units this season. In fact, statistically they have been the worst with 440.3 yards allowed per game. Kirk Cousins is coming off a big performance with 323 yards and 3 touchdowns against the Hawks.

The 49ers are 10th in the league with 28.7 points scored per game. Jimmy G has not done anything to get himself benched this season. He’s thrown 4 touchdowns and 1 interception on 67.4% completions. Trey Lance is waiting in the wings, and has been used in certain offensive sets, but hasn’t had an opportunity to run the offense.

This has typically been a high-scoring series between the Seahawks and 49ers in recent memory. They used to get into some slug it out defensive battles over five years back, but things have changed. The OVER is 5-0-1 in their last six meetings going back to December of 2018. There’s another good chance of an OVER game between these two.


Seahawks vs. 49ers Pick