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Clemson Tigers vs Louisville Cardinals Prediction

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For every pick our AI engine makes, it also assigns a score from 1-100 reflecting how “confident” we are each pick is likely to hit. The higher the score, the more confidence our AI models are that our picks are going to be winners.

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The Louisville Cardinals will beat the Clemson Tigers. The Louisville Cardinals will cover the spread, and the total will go over.

Analyzing the offensive capabilities of both teams, Louisville presents a compelling case. They average 31.3 points per game, surpassing Clemson’s 28.4 points. This edge, coupled with Louisville’s more balanced offensive attack, which includes 243.3 passing yards and 145.3 rushing yards per game, gives them a significant advantage. The Cardinals possess a completion rate of 64.1%, indicating effective passing situations and favorable third-down conversions. In contrast, while Clemson’s passing game is slightly more productive at 296.9 yards, they have only averaged 123.8 rushing yards per game. This imbalance suggests they may struggle to establish a ground game against a Cardinals defense that allows an average of less than 150 rushing yards.

Defensively, both teams exhibit strengths and weaknesses, but the key factor tonight will be the Cardinals’ ability to exploit the weaknesses in Clemson’s rush defense. Moreover, when examining scoring potential, with both teams averaging over 28 points per game, the expectation for a higher game total becomes apparent. If Louisville can maintain their current momentum while capitalizing on the vulnerabilities in Clemson’s secondary, this matchup not only favors the Cardinals to win but also points toward a higher-scoring affair. Overall, the statistical advantages lean in favor of Louisville across the board.

User Consensus Picks

For every pick our AI engine makes, it also assigns a score from 1-100 reflecting how "confident" we are each pick is likely to hit. The higher the score, the more confidence our AI models are that our picks are going to be winners.

Here is the betting public’s consensus picks for the spread, moneyline, and total for today’s game. Log in with a free account and add your picks to the tally.

Spread Nov 14, 2025
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Moneyline Nov 14, 2025
lou clem
Total Nov 14, 2025

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