The Indianapolis Colts are the biggest betting favorites in Week 1 at -7.5 against the Houston Texans. Defending Super Bowl champions Los Angeles Rams have the smallest spread among favorites at -1 against the Buffalo Bills. Only six home teams are favorites in Week 1 led by the Tennessee Titans who are a -6.5 against the New York Giants. The betting odds for Week 1 of the 2022-23 NFL season are out after the league released the 16-game ... Read More