nfl

Detroit Lions vs Buffalo Bills Prediction

Game Time:
Spread
Total
Moneyline

A.I. Game Picks

For every pick our AI engine makes, it also assigns a score from 1-100 reflecting how "confident" we are each pick is likely to hit. The higher the score, the more confidence our AI models are that our picks are going to be winners.

See the best bets that The Geek is favoring for today’s matchup.

Spread
Moneyline
Total

For every pick our AI engine makes, it also assigns a score from 1-100 reflecting how “confident” we are each pick is likely to hit. The higher the score, the more confidence our AI models are that our picks are going to be winners.

The Detroit Lions will beat the Buffalo Bills. The Detroit Lions will cover the spread, and the total will go over.

Analyzing the offensive prowess of both teams reveals that the Lions have a slight edge in scoring, averaging 28.9 points per game compared to the Bills’ 28.2. Additionally, the passing efficiency of the Lions is impressive, with an average of 264.8 passing yards per game on a 68.8% completion rate. In contrast, the Bills throw for 236.3 yards on a 69.8% completion percentage. While both teams are effective through the air, the Lions’ ability to stretch the field more consistently can prove critical in this matchup.

Moreover, the rushing efforts of both teams provide significant insights. The Bills rush for an average of 155.2 yards per game, but they do so on nearly 32 attempts, indicating a strong reliance on their running game. The Lions, however, with 119.9 rushing yards on about 26 attempts, are more balanced in their offensive play, demonstrating their ability to score regardless of the method. This offensive versatility, paired with the Lions’ solid scoring average, sets the stage for a high-scoring game that likely leads to the total points exceeding expectations. Ultimately, I project Detroit’s balanced attack will overwhelm Buffalo’s defense and secure a confident victory.

User Consensus Picks

For every pick our AI engine makes, it also assigns a score from 1-100 reflecting how "confident" we are each pick is likely to hit. The higher the score, the more confidence our AI models are that our picks are going to be winners.

Here is the betting public’s consensus picks for the spread, moneyline, and total for today’s game. Log in with a free account and add your picks to the tally.

Spread Sep 17, 2026
buf det
Moneyline Sep 17, 2026
buf det
Total Sep 17, 2026

Expert Insights All In One Place

Find related content from one of our sports betting experts below.

Kyle Eve profile picture

Kyle Eve

Total Points

Detroit Lions OVER 24.5 Points

100
Kyle Eve profile picture

Kyle Eve

NFL Total Points buf vs det, Sep 17, 2026

Detroit Lions OVER 24.5 Points

100

Buffalo allowed 31 points against Houston in Week 1.

Detroit averaged 28.3 points last season.

The Lions scored 31 points against New Orleans in Week 1.

View Full Pick Analysis

1st Quarter Points

Buffalo Bills OVER 6.5 Points

-145
Kyle Eve profile picture

Kyle Eve

NFL 1st Quarter Points buf vs det, Sep 17, 2026

Buffalo Bills OVER 6.5 Points

-145

Buffalo only scored three 1st-quarter points against Houston, but got going quickly thereafter.

Detroit allowed 469 yards total against the Saints.

Josh Allen has plenty of targets, and can run the ball himself.

View Full Pick Analysis

Total Rushing Yards

Jahmyr Gibbs (DET) OVER 90.5 Rushing Yards

-115
Kyle Eve profile picture

Kyle Eve

NFL Total Rushing Yards buf vs det, Sep 17, 2026

Jahmyr Gibbs (DET) OVER 90.5 Rushing Yards

-115

Jahmyr Gibbs ran for 156 yards against New Orleans in Week 1.

Buffalo allowed 124 yards against Houston.

The Bills were one of the worst run defenses in the NFL last season, allowing 136.2 yards per game.

View Full Pick Analysis

Total Passing Yards

Josh Allen (BUF) OVER 249.5 Passing Yards

-116
Kyle Eve profile picture

Kyle Eve

NFL Total Passing Yards buf vs det, Sep 17, 2026

Josh Allen (BUF) OVER 249.5 Passing Yards

-116

Josh Allen threw for 334 yards in Week 1.

Allen has now thrown for at least 262 yards in his last four games, and over 250 yards in nine of his last 13 games.

Detroit allowed Tyler Shough to throw for 410 yards last week.

View Full Pick Analysis

Anytime TD

Amon-Ra St. Brown (DET) Anytime TD

100
Kyle Eve profile picture

Kyle Eve

NFL Anytime TD buf vs det, Sep 17, 2026

Amon-Ra St. Brown (DET) Anytime TD

100

Amon-Ra St. Brown had two touchdowns against New Orleans.

St. Brown was targeted 14 times by Jared Goff.

Buffalo allowed a touchdown to Houston’s WR1, Nico Collins.

View Full Pick Analysis

Game Lines

Find value in every game by comparing these top sportsbook’s odds for today’s matchup.

Line History

See the odds in motion and unpack the market moves that shape today’s betting landscape.

DateSpreadMoneylineTotal

Top Game Props