The NFL Comeback Player of the Year odds feature two favorites in the second part of the season, but there’s still time for a twist. Dak Prescott and Christian McCaffrey are leading the way, but is backing one of them the best prediction?
I’m here to help by exploring the latest COTY odds for the 2025-26 season and analyzing all the main contenders. If you read to the end, you will find my prediction for the 2025 Comeback Player of the Year.
2025-2026 Comeback Player of the Year Odds
See the table below for the preseason NFL Comeback Player of the Year odds, courtesy of BetUS.
| PLAYER | CPOY ODDS |
|---|---|
| Christian McCaffrey (SF) | -130 |
| Dak Prescott (DAL) | +120 |
| Aidan Hutchinson (DET) | +1400 |
| Daniel Jones (IND) | +3500 |
| Stefon Diggs (NE) | +3500 |
| Rashee Rice (KC) | +8000 |
| Trevor Lawrence (JAX) | +8500 |
| Christian Watson (GB) | +15000 |
| J.J. McCarthy (MIN) | +15000 |
| Cooper Kupp (SEA) | +20000 |
San Francisco 49ers running back Christian McCaffrey (-130) has emerged as the top favorite to win the 2025-26 NFL Comeback Player of the Year award. McCaffrey began the season with the third-best odds, but his line has now shifted from +350 to -130. At -130, McCaffrey holds a 56.5% implied probability of receiving the honor.
According to the updated NFL Comeback Player of the Year betting odds, McCaffrey and Dallas Cowboys quarterback Dak Prescott (+120) are the leading contenders. Prescott’s odds imply a 45.5% chance of winning, followed by a steep drop to Aidan Hutchinson (+1400) at just 6.7%.
Hutchinson and the rest of the field are considered longshots, but with over a month of regular season left, there’s still time for him or another underdog to make a strong case down the stretch in December.
If you want to see more candidates, you can find the Comeback Player of the Year odds at BetUS > Sportsbook > NFL > NFL Season Awards > Comeback Player of the Year.
NFL Comeback Player of the Year Favorites
As we discovered above, McCaffrey and Prescott are the only players as frontrunners. The odds at the top NFL betting sites suggest the race should go down to the wire, so let’s break down McCaffrey and Prescott’s chances below:
Christian McCaffrey (-130)
After returning from multiple injuries last season, including Achilles, calf, and PCL tears, McCaffrey is now the frontrunner for Comeback Player of the Year. He missed the first eight games last season due to Achilles and calf issues, then suffered a PCL injury in a Week 13 loss to the Buffalo Bills.
McCaffrey is no stranger to accolades. The 29-year-old won the 2023 NFL Offensive Player of the Year award after leading the league in rushing and is a three-time All-Pro with several honors from his college career at Stanford.
Now, he’s on the verge of adding NFL Comeback Player of the Year to his collection. This season, McCaffrey has rushed for 796 yards and seven touchdowns at 3.7 yards per carry, and he’s added 785 receiving yards and five scores.
Christian McCaffrey joins Larry Centers and HOF Marshall Faulk as the only RBs in NFL history to have 50+ rec yards in at least 50 career games 💥@49ers | #FTTB pic.twitter.com/zf23XJoNhu
— NFL+ (@NFLPlus) November 25, 2025
He’s been more productive as a receiver, but has contributed efficiently in both areas. With the 49ers also getting healthier, the improved roster results are evident in the standings. At 8-4 through 12 games, the 49ers are playoff contenders, thanks largely to McCaffrey’s outstanding play among NFL running backs this season.
Still, is there enough value in backing McCaffrey at -130, given the tight race with Prescott?
Dak Prescott (+120)
Prescott was the front-runner for CPOY in 2021 but ultimately lost the award to Joe Burrow. Burrow also won the award last year, so Prescott does not need to worry about the Bengals’ quarterback stealing the award from him this season. Burrow has also been absent since Week 2 with another injury.
Last year, Prescott suffered a season-ending hamstring injury in Week 9. The injury was classified as a partial avulsion of his right hamstring, resulting in a tendon separating from the bone and requiring surgery. It’s been a tough road back for Prescott, who has dealt with various ailments throughout his career.
Dak Prescott is now the Cowboys’ all-time passing leader, surpassing Tony Romo 😤
History made. pic.twitter.com/McXkRdcNsR
— ESPN (@espn) November 23, 2025
On the heels of a 21-point comeback win over the Philadelphia Eagles, Prescott is right in the mix as an NFL Comeback Player of the Year contender. He passed for 354 yards with two touchdowns and an interception in the clutch performance. It was almost a must-win for the Cowboys, as they advanced to 5-5-1 on the season.
They are behind in the playoff race, but with newfound confidence from that win over the Eagles, there is still plenty of time to play catch up. After falling behind 3-5-1 and seemingly out of the picture, the Cowboys at least have a decent glimpse of the postseason now.
Without Prescott, that isn’t a possibility for the Cowboys. He’s been fantastic during their recent stretch, passing for six touchdowns and one interception in the last two games. Overall, Prescott has thrown for 2,941 yards, 23 touchdowns, and seven interceptions on 69.3% completions.
If the Cowboys finish strong this season, the quarterback bias toward Prescott could be too strong over McCaffrey!
Best Comeback Player of the Year Sleepers
Sleeper picks are a great way to maximize your potential winnings from betting on CPOY betting lines. Here are my two top sleeper picks for the 2025 Comeback Player of the Year.
Comeback Player of the Year Prediction and Betting Pick
As Thanksgiving approaches, Prescott leads my 2025-26 NFL Comeback Player of the Year predictions. While McCaffrey is currently favored, I believe it will be a razor-thin margin between Prescott and the 49ers’ running back in voting.
Voters often give quarterbacks the edge in close contests, with signal-callers having won this award for seven consecutive years, and 13 in total since the 2008 season. If McCaffrey had a clear advantage, I would favor his odds, but with the competition so close, backing the underdog makes sense.
Therefore, I recommend supporting Prescott as this season’s top pick for NFL Comeback Player of the Year!
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