NFL Comeback Player of the Year Betting Odds and Predictions for 2025-26

Dak Prescott (+275)

Prescott was the front-runner for CPOY in 2021 but ultimately lost the award to Joe Burrow. Burrow also won the award last year, so Prescott does not need to worry about the Bengals’ quarterback stealing the award from him this season.

Prescott is tied for the best odds to win CPOTY this season at +275. However, he has multiple advantages over the other co-favorite, Aidan Hutchinson.

Dak Prescott on what to expect from this season’s Cowboys offense: “An exciting offense. We’ve kept it vanilla for a reason. Excited about getting out there and putting it all on display next Thursday.” pic.twitter.com/HVFDEwrWxo

— Jon Machota (@jonmachota) August 25, 2025

First, Prescott plays in Dallas, which will have plenty of media attention. He should have one of the top receiver duos to work with in CeeDee Lamb and George Pickens. Also, being a quarterback gives him an edge over any non-QB. For reference, all of the previous seven CPOY winners have been quarterbacks.

In 2023, his last healthy season, Prescott finished second in MVP voting. He amassed 4,516 passing yards and 36 passing TDs while leading Dallas to a 12-5 record.

The challenges for Prescott are, first and foremost, staying healthy. Dak has missed at least five games in three of the last four seasons. Also, Prescott must master a new offense now that Brian Schottenheimer is the head coach.

You can find arguments against him, but if the quarterback is healthy for most of the season, he should easily generate impressive numbers and fight for the Comeback Player of the Year award.

Aidan Hutchinson (+275)

The other co-favorite in this year’s NFL Comeback Player of the Year odds is Detroit’s Aidan Hutchinson. He missed 12 games last year after breaking his leg in the Lions’ Week 6 matchup with the Cowboys.

Hutchinson had 7.5 sacks in his five starts last year. At the time of his injury, he was leading the NFL in sacks.

Insane: Lions star DE Aidan Hutchinson has been so dominant during training camp that Dan Campbell has implemented a “Hutch Rule”, allowing a play to continue even if Hutchinson blows it up from the start.

“It’s the only way the offense can get reps,” Campbell said.

Aidan… pic.twitter.com/FisZ7AM1lf

— Dov Kleiman (@NFL_DovKleiman) August 6, 2025

Returning to form after breaking his leg will be easier said than done. However, the Lions are confident in their young pass rusher. Detroit picked up Hutchinson’s fifth-year option this offseason.

The severity of Hutchinson’s injury is not the only hurdle he must overcome. Since the turn of the century, only four defensive players have won CPOY. The last defender to take home the award was Eric Berry in 2015.

Detroit also had to hire a new defensive coordinator after Aaron Glenn accepted the job as the Jets’ head coach. It is unknown how Hutchinson will perform in Kelvin Sheppard’s, the new DC,  scheme.

On the bright side, Hutchinson can stand out early by racking up sacks. If he can replicate his start from last year, he will be a Defensive Player of the Year candidate as well as a CPOY frontrunner.

Christian McCaffrey (+350)

Rounding out the top three of the preseason Comeback Player of the Year betting lines is San Francisco’s Christian McCaffrey. The former All-Pro and Offensive Player of the Year winner is listed at +350 to win CPOY this year.

McCaffrey only appeared in four games last season. He missed the first eight games of the season while dealing with Achilles and calf injuries. Then, in the 49ers’ Week 13 loss to Buffalo, McCaffrey suffered a PCL injury that knocked him out for the remainder of the year.

#49ers RB Brian Robinson on teaming up with Christian McCaffrey:

“We gonna be the best duo in the league." pic.twitter.com/cAyeYJ7nBA

— OurSF49ers (@OurSf49ers) August 25, 2025

When healthy, CMC is one of the best running backs in the league. If he can return to his 2023 form, McCaffrey will run away with CPOTY.

San Francisco needs McCaffrey to be great this season. The team traded away Deebo Samuel, and its top remaining receivers, including Brandon Aiyuk, are dealing with injuries. McCaffrey should see plenty of touches as a result.

On the other hand, McCaffrey only played eight or more games twice in the last five seasons. Also, the 49ers recently traded for Washington’s Brian Robinson Jr. The addition of Robinson Jr. should lighten McCaffrey’s workload, making it easier to stay healthy, but also reducing his chances to rack up stats and win CPOY.