Baltimore’s Derrick Henry is the early-season favorite in this year’s NFL Offensive Player of the Year odds. Fellow running backs Saquon Barkley, Bijan Robinson, and Christian McCaffrey join Henry at the top of updated odds boards. Can a sleeper upset the big dogs, though?
Let’s analyze the latest NFL OPOY betting odds, the top favorites, and other potential winners before I share my Offensive Player of the Year predictions.
NFL Offensive Player of the Year Odds 2025-26
Here are the latest NFL Offensive Player of the Year betting odds, courtesy of Bovada.
| Player | Odds |
|---|---|
| Derrick Henry | +425 |
| Saquon Barkley | +750 |
| Bijan Robinson | +900 |
| Christian McCaffrey | +900 |
| Ja’Marr Chase | +1000 |
| Jahmyr Gibbs | +1400 |
| Justin Jefferson | +1600 |
| Puka Nacua | +1600 |
| CeeDee Lamb | +1700 |
| Nico Collins | +2200 |
| Malik Nabers | +2500 |
| Amon-Ra St. Brown | +3000 |
Henry’s 169 rushing yards led the NFL in Week 1, so it is not surprising to see the King at the top of the latest OPOY markets at top NFL betting sites.
At +450 odds, Henry has an implied win probability of 19.05%. He won OPOY in 2020 and was an early favorite for the award last season before ultimately losing out to Barkley.
Speaking of Barkley, the reigning OPOY is listed at +750 to repeat this season. Robinson and McCaffrey are tied for the next-best odds at 9-1 each. Bengals WR Ja’Marr Chase rounds out the top five at +1000 odds and has the best chances, 9.09%, of any receiver.
See the latest odds and bet on your predictions today by going to Bovada and following these steps: All Sports > Football > NFL Awards & League Leaders > Offensive Player of the Year.
NFL Offensive Player of the Year 2025-26 Betting Favorites
Four running backs lead the latest OPOY betting odds for the 2025-26 season. Let’s take a closer look at each of the favorites in this year’s Offensive Player of the Year race.
Derrick Henry (+425)
Henry and the Ravens had one of the best starts to the 2025 season through three-and-a-half quarters. Baltimore was up 40-25 on the road, and Henry looked unstoppable with the ball in his hands.
Unfortunately, the Ravens could not finish the job, and a costly Henry fumble helped spark a Bills comeback.
DERRICK HENRY IS 31 YEARS OLD AND STILL COOKIN' 🔥
Henry's first half vs. Bills:
▪️ 9 carries
▪️ 123 yards
▪️ 1 TD pic.twitter.com/0aOA3venIN— SportsCenter (@SportsCenter) September 8, 2025
The fumble aside, Henry’s stats from the opener are nothing short of impressive. He had 169 rushing yards on 18 attempts, for an outstanding 9.4 yards per carry. Henry also caught his lone target for 13 yards.
Despite being 31 years old, Henry looked every bit as good as he did last season when finished fourth in OPOY voting after racking up 2,100+ scrimmage yards.
If Henry can stay healthy and repeat his performance from last year, he will be a contender for OPOY once again. However, his usage rate is concerning for a player his age, and one injury could derail his OPOY campaign.
Saquon Barkley (+750)
Saquon Barkley earned 34 of 49 first-place votes for Offensive Player of the Year last season. Barkley’s extraordinary first season in Philadelphia helped lead the Eagles to Super Bowl 59, where they won their second Lombardi Trophy in franchise history.
Imagine telling a Giants fan after the 2023 season that Saquon Barkley would have:
— Rushed for 2,000 yards
— Signed a record-breaking extension
— Won OPOY
— Won a Super Bowl
— Got voted as the best player in the leagueAll while playing for the Eagles 🤣🤣 pic.twitter.com/GNCydDvjr5
— AJ Muse (@aj_muse_) September 2, 2025
The Eagles won their season opener against Dallas, but Barkley was mostly held in check. He had 84 scrimmage yards on 22 total touches and averaged just 3.3 yards per rush.
Barkley had 378 total touches last season, the most in the NFL. He averaged 6.0 yards per touch, a career-high, and led the league with 125.3 rushing yards per game last year.
He figures to be a major part of the Eagles’ offense again this season. However, the three-time Pro Bowler is unlikely to be as efficient in 2025 as he was in 2024. A natural regression in production would prevent Barkley from winning OPOY again this year.
Bijan Robinson (+900)
Expectations are high for Bijan Robinson in his third year in Atlanta. The Falcons’ running back lived up to the hype in Week 1, racking up 124 scrimmage yards, including a 50-yard receiving touchdown.
Robinson is listed at 9-1 odds to win OPOY this year, giving him a 10% chance to win the award this season.
BIJAN ROBINSON. TOUCHDOWN.
FOX | NFL+ pic.twitter.com/1G2hEDZgXw
— Atlanta Falcons (@AtlantaFalcons) September 7, 2025
Last year, Robinson posted career-highs in:
-
- Rush attempts – 304
- Rushing yards – 1,456
- Rushing TDs – 14
- Receptions – 61
Despite gaining 1,887 scrimmage yards last season, Robinson did not earn a single vote for OPOY. On the bright side, he did earn his first Pro Bowl nomination.
Robinson was third in rushing yards last season and tied for fifth in rushing scores. If he can take another step forward and cement himself as the top running back in the league, Robinson could also win OPOY.
Christian McCaffrey (+900)
The other running back listed at 9-1 odds to win OPOY this season is Christian McCaffrey. He won the award in 2023 after leading the NFL with 2,023 scrimmage yards. McCaffrey also finished third in NFL MVP voting that season.
Unfortunately, McCaffrey missed all but four games last year due to calf and knee injuries. His absence last season was a major reason the 49ers missed the playoffs.
Christian McCaffrey said last week’s calf injury was “nothing.” Here he is on playing without Purdy and the team’s confidence in Mac Jones. pic.twitter.com/YcJgEKQq2G
— Vic Tafur (@VicTafur) September 10, 2025
McCaffrey returned this season and is a leading candidate for Comeback Player of the Year. In Week 1, McCaffrey gained 142 scrimmage yards, but he is still looking for his first touchdown since 2023.
The veteran RB will see plenty of work this year if he can stay on the field. San Francisco lost multiple starters to injury in their Week 1 win over Seattle.
As one of the few healthy starters left, McCaffrey must shoulder the load to keep the 49ers in the hunt for the NFC West division title. If he lives up to the challenge, McCaffrey’s odds to win OPOY should shorten significantly.
Top Offensive Player of the Year Sleepers for 2025-26
Betting early in the season is the best way to capitalize on OPOY sleeper odds. My two top dark horses for OPOY this season are Brock Bowers and Travis Etienne.
2025-26 NFL Offensive Player of the Year Prediction and Betting Pick
The OPOY award has become the MVP for non-quarterbacks in the NFL. Running backs have won the award the most, and three of the last five winners have been RBs. So, it is not surprising that RBs dominate the latest OPOY betting odds.
My NFL OPOY prediction is a running back, but it is not Derrick Henry (+425) or Saquon Barkley (+750). Instead, I am picking Bijan Robinson (+900) to earn OPOY honors this season.
Robinson is in a prime position to build on his breakout sophomore season. Atlanta is transitioning to a new quarterback, and having a reliable playmaker like Robinson will go a long way in helping Michael Penix Jr.’s development.
There are fantastic sleeper options, too, including Travis Etienne Jr. He had the second-most rushing yards in the league in Week 1 and should benefit from Liam Coen’s run scheme throughout the season.
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