Anytime TD Scorer Predictions This Week: Who Will Score a Touchdown in Week 18?

Tetairoa McMillan (+150): Panthers vs. Buccaneers

Tetairoa McMillan at +150 to score a touchdown looks like one of the sharper props on the board for Panthers vs. Buccaneers.

Panthers HC Dave Canales on Tetairoa McMillan:

"Our focal point is T-Mac. I didn't do a good enough job [of getting him the ball] last week & we'll make sure that comes alive."

(via @josephperson) pic.twitter.com/FsEI63r6Vj

— SleeperNFL (@SleeperNFL) December 29, 2025

Tampa Bay’s pass defense has been a funnel for opponents in recent weeks, giving up seven passing touchdowns over its last three games. McMillan already found the end zone against this same Bucs group in Week 16, and that history matters when we talk about matchup-based confidence.

McMillan leads Carolina with 929 yards receiving and seven receiving touchdowns while serving as Bryce Young’s most trusted target. His total of 116 targets nearly doubles the next Panther receiver, showing just how central he is to this offense.

He has seen seven or more targets in ten of his sixteen games, including ten targets against Tampa Bay in his last meeting. With volume and red zone opportunity on his side this weekend, McMillan is in a position to pay off this anytime touchdown wager.

Christian McCaffrey (-200): Seahawks vs. 49ers

Christian McCaffrey at -200 might not offer long odds, but he brings high reliability to the anytime touchdown market in the 49ers vs. Seahawks rematch.

McCaffrey has been the engine of San Francisco’s offense, leading the team with 2,069 scrimmage yards and a league-high 399 touches. He’s found the end zone 17 times, splitting his scoring almost evenly between 10 rushing and seven receiving touchdowns, a testament to his elite dual-threat ability.

CMC averages nearly 25 touches per game, making him one of the most involved skill players in the NFL. While he was held out of the end zone in Week 1 against Seattle, that was one of only four games all season where he didn’t score.

In a revenge spot and with the number one seed on the line, expect the 49ers to lean heavily on their offensive cornerstone. McCaffrey is as safe a bet as there is to find paydirt in Week 17.

AJ Barner (+150): Seahawks vs. 49ers

AJ Barner at +150 offers substantial value in the touchdown prop market ahead of Seahawks vs. 49ers.

Barner has quietly carved out a consistent role in Seattle’s passing game, ranking third in targets (65) and receiving yards (505), while sitting second in receptions (50) and touchdowns (6). He’s become a dependable red zone weapon and a trusted safety valve underneath.

#Seahawks AJ Barner is emerging as one of the best tight ends that we have had in a very long time:

[🎥: NFL on CBS]pic.twitter.com/h1fyTt2ELn

— HawkMania (@hawkmania4) December 28, 2025

With Jaxon Smith-Njigba drawing top coverage as the league’s leading receiver, Barner has benefited from softer matchups all season.

That trend should continue against a San Francisco defense that has struggled against tight ends, allowing 10 receiving scores to the position this year. Add in injury concerns across the 49ers’ defense, and Barner’s chances to exploit mismatches only grow.

In a game where Seattle may need to counterpunch through the air, Barner is a sneaky bet to cash this anytime touchdown prop.

Derrick Henry (-167): Ravens vs. Steelers

Derrick Henry at -167 is an enticing play in the Ravens vs. Steelers matchup, especially with Lamar Jackson questionable for Week 17.

Henry has exploded lately with six touchdowns over his last two games, and Baltimore will likely lean on him again if Jackson sits or is limited.

Although he didn’t score in the first meeting with Pittsburgh, Henry still put up 94 yards on 25 carries in Week 14, showing he can grind out production even against tough fronts. With the Ravens’ passing game potentially hampered, Henry becomes the focal point of the offense in a must-win divisional game.

He’s been consistent down the stretch, topping 100 scrimmage yards in six of his last seven while averaging 5.4 yards per touch. Add in 15 receptions at 10 yards per catch this season, and it’s clear Henry’s scoring upside isn’t limited to the ground. The volume, form, and matchup line up for King Henry to strike again.