2025 NFL Week 13 Betting Preview: Odds, Lines, and Best Bets

The NFL Week 13 odds and betting lines include a full slate of games, with all teams in action! This week also includes three games on Thursday in honor of Thanksgiving, as well as a special Black Friday game with significant implications in the NFC.

Keep reading to see the latest NFL Week 13 odds. I break down the latest lines for every game and give my best bets for Week 13.

2025 NFL Week 13 Odds and Betting Lines (Snapshot)

Bovada Sportsbook provided the following betting lines for NFL Week 13.

The 2025 Thanksgiving games feature three exciting matchups: Packers vs. Lions (-2.5), Chiefs (-3) vs. Cowboys (+3), and Bengals vs. Ravens (-6.5). Dallas is the only home team that is an underdog on Thursday.

Then, before an action-packed Sunday slate, the Bears take on the Eagles on Black Friday. Philadelphia, which allowed 24 unanswered points in its loss last week, is laying a touchdown at home.

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Green Bay Packers vs. Detroit Lions Preview: Odds, Betting Lines, Best Bets

The Week 13 action kicks off on Thanksgiving with the Lions hosting the Packers. Green Bay dominated this matchup in Week 1, taking down the Lions 27-13.

Despite that win, the Packers are the road underdogs in this rematch. Detroit are 2.5-point home favorites in this pivotal NFC North matchup. Green Bay are +120 moneyline underdogs on Thursday.

The Lions are 3-3 in their last six appearances, and they have not won back-to-back games since early October. They are also 0-4 this season when Jahmyr Gibbs does not score at least one TD.

Green Bay’s defense can get after the quarterback, and Jared Goff is a different player when he gets hit. The Packers also have one of the top run defenses, allowing under 100 rushing YPG. Micah Parsons and company should be the deciding factor in the game, helping Green Bay pull off the upset in Detroit.

Kansas City Chiefs vs. Dallas Cowboys Preview: Odds, Betting Lines, Best Bets

The second game of Thanksgiving’s triple-header will see the Chiefs take on the Cowboys in Dallas. Both teams are fighting to keep their playoff hopes alive and earned major wins last week.

Kansas City are 3-point road favorites this week. Despite their reputation, though, the Chiefs have looked vulnerable this season. KC is just 1-4 on the road, while Dallas is 3-1-1 at games in Jerry World.

The Cowboys’ offense has been especially great at home, averaging 33 PPG at home. For reference, the Colts currently lead the NFL at 31 PPG this season.

KC shut down the Colts’ offense in the second half last week, allowing Patrick Mahomes and company to lead a comeback when down 20-9 in the fourth. The Chiefs’ defense faces another tough test this week, but Mahomes and company will have an easier time moving the ball on a weak Cowboys’ pass defense.

The Chiefs have the better defense, and the Cowboys’ poor passing defense will be their Achilles heel on Thursday. KC should win and cover, knocking Dallas back below .500 on the season. 

Cincinnati Bengals vs. Baltimore Ravens Preview: Odds, Betting Lines, Best Bets

Rounding out the Thanksgiving Day NFL games is an AFC North matchup between the Bengals (3-8) and the Ravens (6-5). Despite their records, this divisional matchup could shake up the AFC playoff picture.

Records rarely matter in divisional games, and the Bengals’ explosive offense should be even better this week with Joe Burrow returning to the lineup. Burrow missed nine games with a turf toe injury, and Cincinnati went 1-8 without its franchise quarterback.

Even with Burrow returning to the lineup, the Bengals are 6.5-point road underdogs on Thursday.

Baltimore has won five straight games to bounce back from its 1-5 start. Lamar Jackson has been limited in his return from a hamstring injury, and he also hurt his ankle this week. However, Derrick Henry and the Ravens’ rushing attack should dominate this game.

The Bengals give up over 155 rushing YPG, the second-most in the league. Henry should carry the day against a weak Bengals’ defense, allowing Baltimore to extend their winning streak and put space between themselves and Pittsburgh.

Chicago Bears vs. Philadelphia Eagles Preview: Odds, Betting Lines, Best Bets

Chicago’s win over Pittsburgh pushed the Bears to 8-3. Philadelphia is also 8-3 after squandering a 21-0 second-quarter lead in Dallas last week.

These teams lead their respective NFC divisions, but the oddsmakers clearly are not buying the Bears as true contenders, yet. Chicago are getting 7 points as road underdogs against Philly this weekend.

Despite having a winning record, Chicago have a -3 point differential this season. Two of the Bears’ three losses this season have come on the road, and Philly is 4-1 in the City of Brotherly Love this year.

The Eagles’ offense is far from the world beaters they were last year. Chicago’s defense is great at forcing turnovers, but they also allow over 26 PPG this season. It may not be pretty, but the Eagles should get back in the win column at home this week against an inexperienced Bears’ team.    

Los Angeles Rams vs. Carolina Panthers Preview: Odds, Betting Lines, Best Bets

Los Angeles earned sole possession of the number one seed in the NFC with a dominant, 34-7 win over the Buccaneers. The Rams will attempt to improve to 3-0 against the NFC South with a road matchup against Carolina.

The Panthers are the biggest underdog of the weekend, getting 10.5 points at home against the conference-leading Rams.

Normally, an East Coast team hosting a West Coast team at 1:00 pm ET could give the home team an advantage. However, the Panthers played on Monday night in San Francisco, so they will not have a travel advantage over the Rams.

Carolina could also be without several key defensive pieces. CB Jaycee Horn, who had two picks in Monday’s loss, exited the game with a concussion. Safety Tre’von Moehrig will also miss this game while serving a one-game suspension.

A weakened Panthers’ defense has no chance to stop a high-flying Rams’ offense. LA should win, but the Panthers can cover the 10.5-point spread at home thanks to their strong running game.

San Francisco 49ers vs. Cleveland Browns Preview: Odds, Betting Lines, Best Bets

The 49ers also won in prime time, taking down the aforementioned Panthers on MNF 20-9. Now, San Francisco heads to Cleveland to face Shedeur Sanders and the Browns.

Brock Purdy and the 49ers are 5.5-point road favorites in this contest. However, Purdy will need to play better than he did last week for San Fran to pick up the road win. Despite the final score, the quarterback threw three interceptions in the 11-point win over Carolina, bringing his season total to seven.

Cleveland have a great defense, and Myles Garrett is chasing the sacks record. He has 15 of the Browns’ 42 sacks this season. The Browns have also forced 15 turnovers, tied for the ninth-most in the NFL.

Purdy has been sacked three times in his four starts, and the 49ers have only allowed 19 sacks this year, the eighth-fewest in the league.

This is Purdy’s third game back after missing most of the season. Assuming he has shaken the rust off, and the 49ers’ line can keep him upright, the QB can lead San Fran to a win this week.

However, the Browns are a good bet to cover the 5.5-point spread at home in a low-scoring game, especially if Purdy’s turnover issues continue.

Houston Texans vs. Indianapolis Colts Preview: Odds, Betting Lines, Best Bets

In one of the most consequential divisional matchups of the weekend, the Texans head to Indianapolis to face the Colts. Indy is coming off a crushing loss at Kansas City. Houston, on the other hand, beat Buffalo on TNF and had extra time to prepare for this game.

The Colts are 6-0 at home and have not lost back-to-back games this season. So, it is not surprising that Daniel Jones and company are 4.5-point home favorites against the Texans. Indy have the highest-scoring offense in the league, putting up 31 PPG.

Houston could be getting C.J. Stroud back this week. However, the offense was more productive while Stroud watched from the sidelines recovering from a concussion.

The Texans averaged 25 PPG and were 3-0 with Mills as the starter. With Stroud as the starter, though, Houston went 3-5 and averaged just 21 PPG.

On the bright side, Houston’s defense has been dominant regardless of who is starting on offense. The Texans allow 16.5 PPG, second-fewest in the league, and are coming off an eight-sack performance against the Bills. Another strong showing this week will help Houston shut down Jonathan Taylor and force Jones into game-losing mistakes.

New Orleans Saints vs. Miami Dolphins Preview: Odds, Betting Lines, Best Bets

The Saints’ forgettable season continued last week with their 24-10 loss against the Falcons. New Orleans (2-9) heads to Miami this weekend to take on the Dolphins, who had a bye last week.

Miami are 6-point home favorites following a bye week. The Dolphins have won three of their last four games, thanks in large part to the work of De’Von Achane.

Achane has 91+ scrimmage yards in six straight games, including 587 yards and three touchdowns in Miami’s last four games. New Orleans allows over 120 rushing YPG, so Achane should have another productive day this weekend against the Saints.

To make matters worse for New Orleans, Alvin Kamara is questionable with a knee injury. Without Kamara, the Saints have little to no chance of covering the spread on Sunday.

Atlanta Falcons vs. New York Jets Preview: Odds, Betting Lines, Best Bets

Another team searching for their third win of the season is the New York Jets. They allowed 20+ points in four straight games and lost 23-10 against the Ravens last week.

The Jets are 2.5-point home underdogs against the visiting Falcons (4-7) this week. Atlanta is far from a perfect team, but starting Kirk Cousins last week helped the Falcons earn an upset win over the Saints.

With Michael Penix Jr. out for the year, Cousins will start again this week. The veteran QB threw his first two touchdown passes of the season last Sunday, and Cousins should rack up more TD passes against the Jets. New York have allowed 18 TD passes and are yet to force an interception this season.

Drake London could return this week for Atlanta. Even if London misses another week, Bijan Robinson should have a productive day against a Jets’ defense that allows over 125 rushing YPG.

Jacksonville Jaguars vs. Tennessee Titans Preview: Odds, Betting Lines, Best Bets

Jacksonville is in a prime position this weekend to pick up a crucial division win. The Jaguars take on the Titans in Tennessee. The Titans, who lost to Seattle last weekend, have the worst record in the NFL at 1-10.

This will be the Jags’ fourth road game in the last five weeks. So far, Trevor Lawrence has led Jacksonville to a 3-2 record on the road. Lawrence and the Jags are 6.5-point road favorites for this game.

Tennessee’s offense has managed 162 points this year, the third-fewest in the NFL at a clip of 15.2 PPG. Part of their issue has been keeping rookie quarterback Cam Ward upright. Ward has been sacked 45 times this year, the most in the NFL.

The Titans’ rookie is averaging 5.9 YPA, the fewest of any QB with at least 200 attempts. Ward faces a tough matchup against Jacksonville, who sit second in the NFL with 13 INTs this season. The Jags’ offense has been inconsistent, but their defense should lead them to a win in Tennessee on Sunday. 

Arizona Cardinals vs. Tampa Bay Buccaneers Preview: Odds, Betting Lines, Best Bets

The Buccaneers, who have lost four of their last five games, look to get back in the win column this week against the visiting Cardinals. Arizona have also struggled to win this season, losing eight of the last nine games.

Both teams have lost three straight games, and the Buccaneers are 2.5-point home favorites in this cross-division NFC Clash.

Jacoby Brissett has helped revitalize the Cardinals’ passing offense, even if that hasn’t led to wins. Brissett has averaged over 310 passing YPG in his six starts, throwing for 11 TDs and just three interceptions.  He could have another great outing this week with Marvin Harrison Jr. potentially returning to the lineup.

Tampa Bay are also getting healthier, with Bucky Irving expected to return. However, starting QB Baker Mayfield is dealing with a sprain in his non-throwing shoulder that knocked him out of last week’s blowout loss to the Rams.

Even with Baker’s injury, the Buccaneers are the better team. Tampa Bay should win, and, given the small spread, the Bucs can also cover as home favorites on Sunday.

Minnesota Vikings vs. Seattle Seahawks Preview: Odds, Betting Lines, Best Bets

Minnesota have struggled with their first-year starting QB J.J. McCarthy. After missing his entire rookie year with a knee injury, McCarthy has started just six of the Vikings’ 11 games this season.

The Vikings are 2-4 when McCarthy starts, including three straight losses. However, after reporting concussion-like symptoms following last week’s loss, McCarthy is at risk of missing this week’s game against the Seahawks. Minnesota’s QB issues are a big reason the team has averaged just 20.4 PPG this year.

Seattle bounced back from a Week 11 loss in LA with a 30-24 win over the Titans in Tennessee. The Seahawks have won five of their last six games and are 9.5-point home favorites against Minnesota.

Sam Darnold has struggled against pressure throughout his career, and Minnesota is one of the most blitz-heavy teams in the NFL. Darnold could have a rough outing against his former team, but the Vikings’ offensive issues will likely keep them from winning this game.

Las Vegas Raiders vs. Los Angeles Chargers Preview: Odds, Betting Lines, Best Bets

The Chargers’ Week 12 bye could not have come at a better time. Los Angeles lost 35-6 in Jacksonville in Week 11 as the Chargers’ mounting injuries became too much to handle.

Following the bye, LA opened the practice window for rookie Omarion Hampton. The first-round pick has been out since Week 5 with an ankle injury. Hampton’s return to the lineup could help a struggling Chargers’ offense that is missing its starting two tackles.

LA are 9-point favorites at SoFi this week against the visiting Las Vegas Raiders. When these teams met in Week 2, the Chargers took down the Raiders 20-9 in Sin City.

The Raiders have fielded one of the worst offenses in the league. Las Vegas has scored 165 points, tied for the fewest in the NFL. They are also one of three teams that have not racked up at least 3,000 total yards of offense this season.

Divisional games can be tough to predict, but the Raiders have been among the worst teams in the league this year. The Chargers should lead this game from start to finish, covering the 9-point spread at home. 

Buffalo Bills vs. Pittsburgh Steelers Preview: Odds, Betting Lines, Best Bets

The Bills and Steelers both lost last week, putting their hopes of winning their respective divisions in jeopardy. Buffalo is 2.5 games behind the Patriots, and Pittsburgh lost the division led to Baltimore.

Pittsburgh have lost four of the last six games and could be without Aaron Rodgers again this week. The Steelers’ defense is a major reason they have been losing, as the once vaunted Steel Curtain is allowing over 360 yards of total offense per game.

Buffalo are 3.5-point road favorites in the Steel City. The Bills are worthy favorites, but they have had their fair share of defensive issues. Buffalo allows 148.9 rushing YPG, third-most in the NFL.

Even if Rodgers plays through his fractured left wrist, the Steelers will need to lean heavily on their running game. Unfortunately, the Steelers are one of seven teams that have averaged fewer than 100 rushing YPG this season.

Pittsburgh’s inept ground attack will keep them from capitalizing on the Bills’ biggest weaknesses. Josh Allen and the Bills, conversely, are in a great position to exploit the Steelers’ subpar defense. Buffalo should win and cover in blowout fashion. 

Denver Broncos vs. Washington Commanders Preview: Odds, Betting Lines, Best Bets

Denver lost the top seed in the AFC last week during its bye week. The good news for the Broncos is that they can move one step closer to winning the AFC West with a prime-time matchup against the Commanders.

Washington are 6.5-point underdogs at home for this Sunday Night Football matchup. The Commanders also had a bye last week, but the time off was not enough for Jayden Daniels to recover from his dislocated elbow.

With Daniels likely out another week, the Commanders’ offense is in a tough spot against the Broncos. Denver have given up 17.5 PPG this year, the third-fewest in the league, and should get Patrick Suirtain II back in its lineup this week.

The Broncos also lead the NFL in sacks with 49, so it could be a long day at the office for Washington’s Marcus Mariota. Denver’s defense should lead the way for a major SNF win by at least a touchdown.

New York Giants vs. New England Patriots Preview: Odds, Betting Lines, Best Bets

The final game of Week 13 is a Super Bowl rematch pitting the Giants against the Patriots in Foxborough. New England have won nine straight games and are 7.5-point favorites at home for this matchup.

New York could get Jaxson Dart back this week. The rookie QB missed the last two games due to a concussion.

If Dart does miss another week, the G-Men will start Jameis Winston. In the last two weeks, Winston has racked up 567 passing yards, two TDs, and two INTs. He also caught a TD pass last week on a trick play.

Drake Maye and the Patriots are a tough out for any team, and they can all but lock up the division title by getting their 11th win of the season this week. Maye can also take another step toward winning the MVP award with a big performance in prime time.

The Giants’ defense is 30th in points allowed (28.5 PPG) and total yards allowed (385 YPG) this season. New York is the perfect opponent for a Pats team looking to cement their status as an AFC Super Bowl contender. 

Where to Find NFL Week 13 Odds and Betting Lines?

Bovada is the ideal place to wager on NFL Week 13 odds. It has competitive lines for all 16 contests on this week’s schedule, including the three Thanksgiving games.

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