2025 NFL Week 15 Betting Preview: Odds, Lines, and Best Bets

The NFL Week 15 odds and betting lines feature a full slate of games, with all 32 teams hitting the field this weekend. We have teams hoping to clinch a playoff spot, key divisional matchups, and more, so it should be exciting.

Let’s analyze the odds for the main markets before I share my Week 15 best bets for all games.

2025 NFL Week 15 Odds and Betting Lines (Snapshot)

Here are the latest Week 15 NFL betting lines, courtesy of Bovada.

Week 15 kicks off with an AFC South showdown on Thursday Night Football. The Buccaneers look to get back in the win column as 4-point favorites against the visiting rival Falcons.

Sunday’s schedule has multiple divisional contests, too, including a battle for the AFC East title between the Bills and the Patriots. The Chiefs look to keep their season alive with the Chargers coming to KCMO. Buffalo and Kansas City are 1 and 4.5-point favorites, respectively.

See the latest betting lines and wager on your Week 15 best bets by going to Bovada and navigating to Sports > Football > NFL > NFL Week 15.

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Atlanta Falcons vs. Tampa Bay Buccaneers Preview: Odds, Betting Lines, Best Bets

Atlanta’s disastrous season continued last week with a 37-9 shellacking at the hands of Seattle. The Falcons are 1-7 in their last eight games, but they have already been eliminated from playoff contention.

Tampa Bay has also struggled in the last two months, winning three of the last eight games. Despite their recent issues, the Buccaneers are 4-point favorites this week at home against Atlanta.

With the exception of last week’s loss to the Saints, most of the Bucs’ struggles have come against teams with winning records. Injuries have also played a significant part in Tampa Bay’s recent skid. However, the team is getting healthier, especially on offense.

When these teams met in Week 1, Tampa gutted out a 23-20 comeback win. With the Falcons’ recent issues, this game should not be nearly as close. A healthier Tampa Bay team should lead wire-to-wire, earning an important divisional win.

Cleveland Browns vs. Chicago Bears Preview: Odds, Betting Lines, Best Bets

Cleveland’s highly-rated defense no-showed in the 31-29 loss to the Titans (2-11) last week. The defeat dropped the Browns to 3-10, officially eliminating Cleveland from the postseason.

On the bright side, Shedeur Sanders authored arguably the best offensive performance of the Browns’ season last week, but it was not enough to get the win. Sanders and company face a much tougher test this Sunday against the Bears. Chicago is a 7.5-point home favorite in this cross-conference matchup.

The Bears are also looking to bounce back from a loss. Chicago came up short 27-20 against the Packers after Caleb Williams threw a game-losing interception in the final seconds.

Cleveland has a great defense at times, but the Browns do not play as well away from home. Add to that the Bears’ need to prove their standing in the conference after losing the number one seed, and this could be a game that gets away from Cleveland quickly.

Chicago leads the NFL in interceptions (18) and total turnovers (27) and will present challenges for a rookie like Sanders. The Bears should win and cover, maintaining their playoff positioning in a tight NFC postseason race.

Baltimore Ravens vs. Cincinnati Bengals Preview: Odds, Betting Lines, Best Bets

Joe Burrow returned on Thanksgiving, leading the Bengals to an upset win over the Ravens. Lamar Jackson and company get a chance to even the score this week as Baltimore takes on the Bengals in Cincinnati.

Both teams lost last week, with the Ravens falling to the Steelers and the Bengals losing on the road in Buffalo. Jackson and the Ravens are 2.5-point road favorites to end their two-game losing streak this weekend.

Despite their losses, both offenses produced points last weekend. Cincy racked up 34 points against the Bills. Baltimore only scored 22, but Jackson ended his rushing TD drought, running the ball to the endzone for the first time since Week 1.

A healthier Jackson is bad news for everyone in the AFC playoff race. His scrambling ability will be the difference maker against a Bengals defense that allows a league-high 155.5 rushing YPG. Baltimore should win and cover, officially ending the Bengals’ season this Sunday.

Arizona Cardinals vs. Houston Texans Preview: Odds, Betting Lines, Best Bets

C.J. Stroud led the Texans to the biggest win of his young career, taking down the Chiefs 20-10 in Arrowhead. The win also kept Houston alive in a highly competitive AFC South race.

Arizona, conversely, lost 45-17 at home to the rival Rams. The Cardinals are getting 10 points on the road in Houston this weekend.

Despite the final score in many of their losses, the Cardinals’ offense has been one of the most explosive units in the league. Jacoby Brisset has a 3:1 TD: INT ratio and is averaging over 300 passing YPG in his eight starts.

Brissett and the Cardinals face their toughest test of the year against the top-ranked Texans defense. On the bright side, Houston’s offensive issues returned when Stroud re-entered the lineup.

Both teams averaged fewer than 22 PPG this season, so this should be a low-scoring game. A low final total will make it challenging for the Texans to cover a double-digit spread. Houston should win, but Brissett and the Arizona offense can cover the 10 points.

New York Jets vs. Jacksonville Jaguars Preview: Odds, Betting Lines, Best Bets

New York became the first team to lose to Tua Tagovailoa in a game that was colder than 45 degrees. Miami leaned heavily on its rushing attack, racking up 239 yards on the ground in the 34-10 road win.

The Jets face another Florida team this week as they take on the Jaguars in Jacksonville. Trevor Lawrence and the Jags are 11.5-point home favorites. A win moves Jacksonville one step closer to winning the AFC South.

Jacksonville have won four straight, with four of those wins coming by 17+ points. In their win last week, the Jags held Jonathan Taylor, the league’s leading rusher, to 74 yards on 21 carries.

The Jags’ defense faces another tough test this weekend against the Jets. New York is seventh in the NFL, averaging 128.4 rushing YPG this season. However, their rushing attack has been less impactful since Justin Fields was benched.

Fields (knee) and Tyrod Taylor (groin) are both questionable for this game, which could force rookie Brady Cook into his first NFL start. Cook completed 14 of 30 passes for 163 yards and two interceptions in relief of Taylor last week.

Any of the Jets’ QBs will struggle against this Jaguars defense, which is T-2nd in turnovers (23) and has 25 sacks this season. Jacksonville should win and cover the spread against an injury-riddled Jets offense.

Los Angeles Chargers vs. Kansas City Chiefs Preview: Odds, Betting Lines, Best Bets

In one of several must-see matchups this weekend, the Chargers (9-4) take on the Chiefs (6-7) with both teams fighting for postseason position. Kansas City must win to keep their playoff hopes alive. The Chargers also need a victory to have any chance of catching the Broncos (11-2) in the AFC West race.

The Chargers survived in overtime against the Eagles (8-5) in Week 14. Justin Herbert played through a surgically repaired broken left hand, completing just 12 passes for 139 yards. However, he also rushed 10 times for a team-high 66 yards.

Kansas City’s offense also struggled last week, earning just 274 total yards in its 20-10 loss at home. The loss ended KC’s five-game home winning streak.

The Chargers’ defense is not on the same level as Houston’s, so Patrick Mahomes and company should have an easier time moving the ball. Also, Mahomes will not make the same mistakes Jalen Hurts did that led to the latter having five turnovers against LA last week.

Mahomes and the Chiefs are desperate, while the Chargers are beat up, especially along the offensive line. KC can win and keep its slim postseason hopes alive for at least another week.

Buffalo Bills vs. New England Patriots Preview: Odds, Betting Lines, Best Bets

Buffalo (9-4) and New England (11-2) also square off this weekend, rounding out their regular-season series. The Patriots won the first matchup 23-20, handing the Bills their first loss of the year.

Despite that win in Orchard Park, the Pats are 1-point home underdogs for the rematch. At 11-2, a win this week will lock up the AFC East for New England. The Patriots had a bye last week, giving them extra time to prepare for this pivotal matchup.

Josh Allen and the Bills needed to score 21 unanswered points in four and a half minutes to pull off a comeback against the Bengals last week. Allen’s record-setting 40-yard TD run was followed by back-to-back interceptions by Joe Burrow to help the Bills secure the win in the snow.

Allen has been nearly unstoppable at times this season. One of the few teams that did limit him, though, was New England. If the Pats’ defense can contain Allen and force the Bills’ other playmakers to win the game, Buffalo will fall short again.

Washington Commanders vs. New York Giants Preview: Odds, Betting Lines, Best Bets

Another rematch from the early season pits the Commanders (3-10) against the Giants (2-11). Washington got the win in Week 1, but their eight-game losing streak is one worse than New York’s (7).

The Giants are 2.5-point home favorites coming off their bye last week. Both of New York’s wins this season have come at home, and the Commanders are 1-6 on the road this season. Washington’s starting QB is also up in the air, after Jayden Daniels’ return was cut short last week.

If Daniels is out, the Commanders could be in serious trouble Sunday. However, if he does play, the quarterback should provide a much-needed spark to Washington’s offense.

Daniels looked rusty at best in his first game back, completing 9 of 20 passes for 78 yards and an interception in the 2+ quarters he played. Another week to get back in rhythm, and an easier defensive matchup should help Daniels play better this week and lead the Commanders to a win.

Las Vegas Raiders vs. Philadelphia Eagles Preview: Odds, Betting Lines, Best Bets

Las Vegas lost a seventh straight game last week, falling to 0-11 against the AFC West over the last two seasons. The Raiders have already been eliminated from the playoffs, but they could play spoiler against a struggling Eagles team this week.

Philadelphia lost a third consecutive game last week, putting the Eagles’ lead in the NFC East in jeopardy. Jalen Hurts committed five turnovers in the loss, including four interceptions.

The Eagles’ offensive struggles are nothing new, and their +18 point differential is the third-lowest of any division leader in the NFL. For reference, the Rams, who lead the NFC West, have a +152 point differential.

Philadelphia have a chance to bounce back this week with what is, in theory, an easy opponent at home. However, their offensive issues make it challenging to trust Philly to cover an 11-point spread. The Eagles should win, but I think the Raiders are a great bet to cover on Sunday.

Green Bay Packers vs. Denver Broncos Preview: Odds, Betting Lines, Best Bets

Two division leaders square off in a must-see matchup in the mid-afternoon window. The Packers (9-3-1) took control of the NFC North with a 27-20 win over the Bears last week. Denver (11-2) moved one step closer to winning the AFC West with a win over the Raiders.

The Broncos have won 10 straight games, tied for the longest active winning streak in the NFL. Despite their recent success, the Broncos are 2.5-point home underdogs against Green Bay this Sunday.

It is Toyotathon, which means Jordan Love is playing at an MVP-level. Love’s Toyotathon legend is well-earned as the QB has racked up 4,239 passing yards, 36 TDs, and just 2 INTs during the event in his career.

Denver has one of the league’s best defenses, leading the NFL with 55 sacks so far this season. If the right Broncos defense shows up this week, they will shut down Love and the Packers’ offense.

On the other hand, Bo Nix and the offense have struggled throughout the team’s double-digit winning streak. If those issues continue, then Nix will be the reason the Broncos suffer their first loss since Week 3.

Detroit Lions vs. Los Angeles Rams Preview: Odds, Betting Lines, Best Bets

Another highly anticipated matchup in the middle window on Sunday pits the Lions (8-5) against the Rams (10-3) in LA. The Rams are 5.5-point home favorites in this matchup of top-scoring offenses in the NFC.

Detroit leads the NFL with 30.3 PPG, while LA is not far behind with 29.3 PPG, the fourth-most in the league. The Rams’ biggest edge lies on the other side of the ball, though.

LA’s defense only allows 17.5 PPG, the third-fewest in the NFL. The Lions, on the other hand, give up 23.4 PPG, which ranks in the bottom half of the league. Detroit’s defense will also be without Pro Bowl safety Brian Branch, who tore his Achilles tendon last week.

The Lions won last week, which could have sealed their fate for this game. Detroit have not won back-to-back games since Week 5, alternating wins and losses ever since.

Detroit’s offense can be derailed by a strong pass rush, and the Rams are sixth in the NFL with 36 sacks this season. LA’s defense should feast against a Lions’ offense line that has struggled recently, pressuring Jared Goff early and often for the win.

Carolina Panthers vs. New Orleans Saints Preview: Odds, Betting Lines, Best Bets

Carolina has a chance to take a late lead in the NFC South this weekend. The Panthers (7-6) are tied for the best record in the division heading into their matchup with the Saints (3-10). If the Panthers win and the Bucs lose, Carolina will be alone atop the division.

Coming off their bye, Bryce Love and the Panthers are 2.5-point road favorites in New Orleans. The Saints are +125 home underdogs in the latest moneyline odds for this Week 15 matchup.

Despite their poor record, the Saints have been a tough out this season. Two of their three wins have been against divisional opponents, including a 17-7 win over the Panthers in Carolina in Week 10.

This is a must-win for the Panthers if they want to win the division. Their remaining schedule includes two games with the Bucs, separated by a game against the Seahawks.

Carolina shocked LA in Week 13, but they have not won back-to-back games since Week 7. With that in mind, I think the Saints are live underdogs in this matchup and can upset an inconsistent Panthers team.

Indianapolis Colts vs. Seattle Seahawks Preview: Odds, Betting Lines, Best Bets

In the biggest mismatch of the week, the Seahawks are 13.5-point home favorites against the visiting Colts. Indianapolis is 8-5, but the Colts have lost four of their last five games.

To make matters worse for Indy, Daniel Jones, who has been battling through a fractured fibula, tore his Achilles tendon in Sunday’s loss to the Jaguars. Backup rookie Riley Leonard was also hurt in the game, spraining his PCL.

With Anthony Richardson already on IR with a fractured orbital, the Colts signed 44-year-old Hall of Fame semifinalist Philip Rivers to their practice squad.

Starting any QB who has been retired for five years is a tough look for any team. Seattle has one of the best defenses in the league, ranking fourth in sacks (41), sixth in yards allowed (288.2 YPG), and second in points allowed (17.4 PPG).

The Seahawks also lead the NFL with a +262 point differential. Seattle should win and cover against a Colts team that has had terrible injury luck at the QB position.

Tennessee Titans vs. San Francisco 49ers Preview: Odds, Betting Lines, Best Bets

The final game in the middle window pits the Titans (2-11) against the 49ers (9-4). San Francisco had a bye last week, while Tennessee earned a second win of the year in a 31-29 shootout against Cleveland.

Arguably, the most impressive part of the Titans’ win last week is that Tennessee only allowed one sack. Heading into the game. Cam Ward had been sacked a league-high 48 times.

It is unlikely, but not impossible, that Tennessee’s offensive line can replicate that performance this week. San Francisco have 16 sacks this season, the lowest in the NFL. If Tennessee manages to keep Ward clean, the Titans at least have a chance to cover the 13-point spread.

San Fran has also struggled to force turnovers, generating just 14 so far this year, tied for the ninth-fewest. Their five interceptions are tied for the second-fewest in the NFL.

The good news for the 49ers is that they have Christian McCaffrey coming off a full week of rest. McCaffrey is averaging over 127 scrimmage YPG and has 13 total TDs this season. Another heavy dose of CMC will lead the 49ers to a win, but Tennessee can cover the spread.

Minnesota Vikings vs. Dallas Cowboys Preview: Odds, Betting Lines, Best Bets

The Week 15 Sunday Night Football matchup sees the Vikings (5-8) take on the Cowboys (6-7) in Dallas. Minnesota ended a four-game losing streak with an impressive 31-0 win over the Commanders last week.

Dallas, on the other hand, lost on TNF last week, coming up short 44-30 in Detroit. The loss ended the Cowboys’ three-game winning streak and knocked Dallas under .500. Despite losing last week, Dallas is a 6-point home favorite in this prime-time matchup.

Minnesota’s defense played lights out in its shutout win on Sunday. On the other hand, they played one of the few teams that have struggled as much as Minnesota. Washington’s Jayden Daniels left the game early in his first action since dislocating his elbow in Week 10.

The Cowboys’ offense is worlds above this year’s Commanders’ team. Assuming Dallas prepares correctly for Minnesota’s blitz-heavy attack, the Cowboys’ offense should lead them to an easy prime-time win on Sunday.

Miami Dolphins vs. Pittsburgh Steelers Preview: Odds, Betting Lines, Best Bets

The final game of Week 15 is a Monday Night Football matchup in Pittsburgh. Miami (6-7) are looking for a fifth straight win against a struggling Steelers team that is 3-5 in its last eight games.

Pittsburgh reassumed first place in the AFC North with a 27-22 win over Baltimore last week. The Steelers are 3-point home favorites in this prime-time matchup.

Tua Tagovailoa had never won an NFL game when the temperature was 45 degrees or colder. That streak ended last week with a 34-10 blowout win over the Jets. Tagovailoa only completed 13 passes for 127 yards, but Miami gained 239 yards on the ground.

Pittsburgh allowed 217 rushing yards last week to the Ravens and gave up over 240 yards to Buffalo the week before.

If Miami sticks to its run-first attack, the Dolphins can cruise to another win this week. De’Von Achane is dealing with a rib injury, but Jaylen Wright proved he can carry the load as the RB1. Miami can earn the upset win and knock the Steelers back to .500 this week.

Where to Find NFL Week 15 Odds and Betting Lines?

Week 15 is here, and there is no better place to bet on every game this week than Bovada. You can wager on competitive lines for every game, including moneyline, ATS, and totals odds for all 16 matchups.

Bovada also offers great bonus promotions for its members to enjoy. New members can get in on the fun by using the code BV1000 to gain a 50% deposit match up to $1,000.

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