2026 NFL Week 10 Betting Preview: Odds, Lines, and Best Bets

Washington Commanders vs. New York Giants Preview: Odds, Betting Lines, Best Bets

Mistakes on both sides cost the Giants and Commanders a chance at a win in their Week 5 meeting, which ended in an anticlimactic tie. They meet again on Thursday, with Washington getting 2 points as a road underdog.

The Giants are -130 favorites on the moneyline, but that could change pending J.J. McCarthy’s health. The quarterback was injured in Sunday’s win over the Eagles and briefly left the game with a hip injury.

#Giants QB JJ McCarthy took a massive hit directly to his throwing shoulder and he's out of the game and now in the locker room.

He tried throwing on the sideline… and it didn't go well. pic.twitter.com/qpNXjKwWGw

— Ari Meirov (@MySportsUpdate) November 8, 2026

He returned, and McCarthy is expected to start on Thursday. However, if he is limited or injured again, it could be Jameis Winston time once again for the G-Men.

Washington has dealt with its fair share of injuries, but poor game management has been the Commanders’ undoing this year. They have also struggled to run the ball, totaling 60 or fewer rushing yards in two of their last three games.

The Commanders are flawed, but McCarthy’s injury could derail the Giants’ momentum. A desperate Washington team is the safer pick on a short week, as long as McCarthy doesn’t start or is not at 100%.

Commanders vs. Giants NFL Week 10 Best Bets:

• Points Spread: Washington Commanders +2 (-112)
• Moneyline Bet: Washington Commanders (+110)
• Over/Under Bet: Under 43 (-110)

New England Patriots vs. Detroit Lions Preview: Odds, Betting Lines, Best Bets

Week 9 was supposed to be a celebration for the Patriots as they honored the 10th anniversary of the 28-3 comeback in Super Bowl 51. Instead, Green Bay dominated New England wire-to-wire, winning 45-27.

The Pats must put that loss behind them as they head to Germany this weekend to face the Detroit Lions. Detroit is a 3-point “home” favorite on Sunday at Allianz Arena in Munich.

Jared Goff and the Lions are also coming off a poor showing. Detroit beat Miami on 19-9 Sunday, but they had just 270 total yards of offense. Before Week 9, the Lions averaged a league-high 395.4 total YPG.

Goff has the weapons to exploit the same holes in the Pats’ passing defense that Jordan Love took advantage of. Jahmyr Gibbs should also have a big game against New England, which allowed 129 rushing yards to a Packers team that had averaged under 61 rushing YPG going into the game.

New England has struggled to get opposing offenses off the field, which is a big reason they have lost two of their last three. Drake Maye can have a big day against a weak Lions’ defense, but it shouldn’t be enough to cover the spread in Munich.

Patriots vs. Lions NFL Week 10 Best Bets:

• Points Spread: Detroit Lions -3 (+100)
• Moneyline Bet: Detroit Lions (-155)
• Over/Under Bet: Over 51 (-112)

Kansas City Chiefs vs. Atlanta Falcons Preview: Odds, Betting Lines, Best Bets

The Chiefs ended their two-game losing streak with a 35-12 win over the Jets. Kansas City dominated the second half, outscoring New York 21-0 after halftime. It was a potentially costly win, though, as QB Patrick Mahomes injured his throwing elbow late in the second quarter.

Mahomes finished the game, and KC is a 3-point road favorite against Atlanta this week despite the injury.

#Chiefs QB Patrick Mahomes underwent an MRI following today’s win and sources say the tests did not reveal a major injury.

Mahomes’ elbow strain/sprain will be monitored over the next few days for pain and swelling. But so far, so good. Mahomes did go back in the game. pic.twitter.com/uWPbBY3Gaa

— Ian Rapoport (@RapSheet) November 9, 2026

Atlanta is coming off a 34-17 loss to the Bengals in Madrid. The Falcons defense allowed 388 yards of offense, and Joe Burrow had four total touchdowns. Atlanta’s defense will have an even tougher time stopping the Chiefs this week after trading Pro Bowl safety Jessie Bates III to Jacksonville.

Mahomes’ elbow injury could limit the Chiefs’ passing attack, but KC has been at its best this year when relying on RB Kenneth Walker III.

After not allowing more than 70 rushing yards in any of its first four games, Atlanta’s defense has given up an average of 175.2 rushing YPG in its last five games. KW3 will shoulder the load again, carrying the Chiefs to their third road win of the year.

Chiefs vs. Falcons NFL Week 10 Best Bets:

• Points Spread: Kansas City Chiefs -3 (-120)
• Moneyline Bet: Kansas City Chiefs (-185)
• Over/Under Bet: Over 45 (-112)

Houston Texans vs. Cleveland Browns Preview: Odds, Betting Lines, Best Bets

Houston (3-5) kept its slim playoff hopes alive with a 44-22 win over the winless Chargers in Week 9. Now, the Texans head to Cleveland to face the Browns (5-4).

Cleveland has lost back-to-back games on the road, but the Browns are 3-0 at home this year. Despite an impressive home record, Cleveland is a 4-point underdog against C.J. Stroud and the visiting Texans.

Houston’s underperforming defense finally lived up to expectations, limiting the Chargers to nine points through the first three quarters. They have another chance to play well this week against a struggling Browns offense.

Deshaun Watson should be back, but even with their starting QB in the lineup, the Browns have averaged just 17.9 PPG, the fourth-fewest in the league. That will not be enough to keep up with the Texans’ explosive offense, which averages 26.1 PPG.

Texans vs. Browns NFL Week 10 Best Bets:

• Points Spread: Houston Texans -4 (-115)
• Moneyline Bet: Houston Texans (-220)
• Over/Under Bet: Under 39.5 (-112)

Miami Dolphins vs. Indianapolis Colts Preview: Odds, Betting Lines, Best Bets

The Dolphins (1-7) head to Indianapolis to face the Colts (2-7) in a showdown between two of the league’s worst teams.

"I appreciate them and it was a pleasure to put on display all of not only my hard work, but the team's hard work."@ADChernoff asked Jonathan Taylor what he hopes the fans will remember about him if this is Taylor's last game with the #Colts: pic.twitter.com/Z6bL4IMT0M

— WISH-TV News (@WISHNews8) November 8, 2026

Indy has dropped five straight games, but the Colts are projected to end their losing streak this week. Oddsmakers have Daniel Jones and Co. listed as 2-point home favorites on Sunday. Miami, on the other hand, is a +115 moneyline underdog.

The Dolphins have struggled to win, but Miami has played well since its Week 6 bye. The team has held two of its last three opponents to under 200 passing yards. The Dolphins were also the first team this season to keep Detroit under 300 total yards.

Indianapolis could also trade Jonathan Taylor before this matchup. If JT is moved before the deadline and the Dolphins remain stout against the pass, Miami can pull off the upset for their second win of the year.

Dolphins vs. Colts NFL Week 10 Best Bets:

• Points Spread: Miami Dolphins +2 (-110)
• Moneyline Bet: Miami Dolphins (+115)
• Over/Under Bet: Under 40.5 (-108)

Carolina Panthers vs. New Orleans Saints Preview: Odds, Betting Lines, Best Bets

At 3-5, the Panthers and the Saints are tied for the best records in the NFC South. They face off on Sunday in a crucial divisional game. New Orleans is favored by a point in this NFC South matchup.

The Saints needed overtime to beat the Browns on Sunday. They also allowed 355 total yards to a Shedeur Sanders-led Cleveland team, including 297 passing yards.

Carolina has lost three straight games, being outscored 96-53 over that stretch. They have not scored over 21 points since mid-October. The Panthers’ passing attack has also struggled, with Bryce Young having 209 or fewer passing yards in two of his last three starts.

New Orleans has held three of its last four opponents to 23 points or fewer. The Saints can get their third win in their last four games if their defense can slow down a struggling Panthers’ passing attack on Sunday.

Panthers vs. Saints NFL Week 10 Best Bets:

• Points Spread: New Orleans Saints -1 (-108)
• Moneyline Bet: New Orleans Saints (-115)
• Over/Under Bet: Under 47.5 (-110)

Jacksonville Jaguars vs. Tennessee Titans Preview: Odds, Betting Lines, Best Bets

Jacksonville takes its league-best +108 point differential to Tennessee this weekend. For comparison, the Titans have a -55 point differential, the fourth-worst in the AFC.

The Titans are massive underdogs coming off their bye. Despite having extra rest, Tennessee is getting 10 points at home against their AFC South rivals. The Jags played Thursday, so they have only a slight rest disadvantage.

Blockbuster: the Jaguars are trading a 2027 first-round pick and a 2029 second-round pick to the Eagles for defensive tackle Jordan Davis, sources tell ESPN.

This is the Jaguars’ third trade for a defensive player today while the Eagles now are poised to have 10 picks in the… pic.twitter.com/NTGnLf2MoT

— Adam Schefter (@AdamSchefter) November 9, 2026

Jacksonville has been rolling lately, outscoring its last two opponents 75-17. They are fourth in points in the NFL, averaging 28.6 PPG. Tennessee, on the other hand, ranks 28th with 18 PPG.

The Jags defense has also been impressive, giving up 15.1 PPG, the second-fewest in the NFL. They rank 10th in total defense, giving up 318.3 YPG, and allow just 89.3 rushing YPG. The recently acquired Jordan Davis should only make the Jags’ defense that much better.

Their stout rushing defense has struggled lately, though, giving up over 100 rushing yards in three straight games. Tennessee had 299 rushing yards combined in its two games prior to the Titans’ bye. If Tony Pollard can get going again this week, he and the Titans can cover the double-digit spread.

Jaguars vs. Titans NFL Week 10 Best Bets:

• Points Spread: Tennessee Titans +10 (-114)
• Moneyline Bet: Jacksonville Jaguars (-500)
• Over/Under Bet: Over 47 (-112)

Los Angeles Rams vs. Arizona Cardinals Preview: Odds, Betting Lines, Best Bets

The Rams’ win over the Commanders pushed LA over .500 for the first time this season. Matthew Stafford has led the Rams to three straight wins, but they are still looking for their first division win of the year.

Oddsmakers have the Rams listed as 7.5-point road favorites over the Cardinals on Sunday. The Cardinals beat LA in Week 6, gaining 338 yards of offense in the 18-16 win.

Breaking: The Rams are expected to place WR Puka Nacua on Injured Reserve with MCL and PCL sprains, plus turf toe, coach Sean McVay announced. pic.twitter.com/XTDA9DeQQl

— ESPN (@espn) November 9, 2026

Arizona has undergone major changes since then, including trading away QB Jacoby Brissett, who started in their Week 6 win. This will be Gardner Minshew II’s second start of the year. He managed just 166 passing yards and a 39.4 QBR in the team’s 17-3 loss. Minshew needs to improve if the Cardinals want to get their first home win of the season.

The Rams are not a lock to win, though, especially with WR Puka Nacua (knee) joining Davante Adams on IR. Nacua and Adams are the only Rams receivers with more than 300 receiving yards this year.

LA’s running game has 124+ rushing yards in three straight games, so the Rams can still move the ball and control the clock if Nacua is out. However, it will be hard to cover the 7.5-point spread with a limited passing attack.

Rams vs. Cardinals NFL Week 10 Best Bets:

• Points Spread: Arizona Cardinals +7.5 (-115)
• Moneyline Bet: Los Angeles Rams (-370)
• Over/Under Bet: Under 44.5 (-112)

Seattle Seahawks vs. Las Vegas Raiders Preview: Odds, Betting Lines, Best Bets

Seattle’s defense led the way to a dominant 17-3 win over the Cardinals on Sunday. It will be tough to repeat that performance this week in Las Vegas.

"Good exam for Drew. He's dealing with an oblique. I think it's something we can manage and him play in the game. Sam will be another week."#Seahawks HC Mike Macdonald provides injury updates on QBs Drew Lock and Sam Darnold on with @BrockHuard & @TheMikeSalk. pic.twitter.com/z8SjQRbf6l

— Seattle Sports (@SeattleSports) November 9, 2026

The Seahawks are 3-point road favorites over the Raiders. However, Seattle has already ruled out Sam Darnold (quad, ribs), and backup Drew Lock is dealing with an oblique injury. Lock was also limited by elbow tendinitis in last week’s win, and Seattle only had 295 yards of offense.

Seattle’s offense must be better to win on Sunday against a Raiders team averaging 26.4 PPG this season.

If anyone knows how to exploit the weaknesses in Seattle’s defense, it should be Raiders’ HC Klint Kubiak. He was the Seahawks’ OC last season and can devise a plan to help Las Vegas pull off the upset on Sunday.

Seahawks vs. Raiders NFL Week 10 Best Bets:

• Points Spread: Las Vegas Raiders +3 (-103)
• Moneyline Bet: Las Vegas Raiders (+150)
• Over/Under Bet: Over 43.5 (-110)

San Francisco 49ers vs. Dallas Cowboys Preview: Odds, Betting Lines, Best Bets

The 49ers (7-1) can move one step closer to securing the top seed in the NFC with a win over the Cowboys (4-5) in Week 10. San Francisco bounced back from its first loss of the season with a 38-17 win over Las Vegas in the first game after the 49ers’ bye week.

Dallas also won last week, edging the Colts 27-23 in Indianapolis. The Cowboys, who are only 1-3 at home this season, are 4-point home underdogs on Sunday.

The Cowboys are ranked 30th in total defense, allowing 372.7 YPG. They are the second-worst run defense, giving up 147.4 YPG, and are tied with the Ravens for the seventh-most points allowed (26.2 PPG) this season.

Dallas’s defensive struggles are nothing new, but their issues on offense are more concerning. Dak Prescott has been held to 255 or fewer passing yards in three of the Cowboys’ last four games. They also have 75 or fewer rushing yards in five of their nine games this season.

Conversely, San Fran has looked nearly unstoppable this year. They rank top three in total defense, allowing 291.9 YPG, and hold opponents to 19.5 PPG. On offense, the 49ers are sixth in total yards (376.8 YPG) and third in points (29.4 PPG).

The 49ers are arguably the league’s most complete team and should lead wire-to-wire against an inconsistent Dallas team that has struggled at home.

49ers vs. Cowboys NFL Week 10 Best Bets:

• Points Spread: San Francisco 49ers -4 (-110)
• Moneyline Bet: San Francisco 49ers (-215)
• Over/Under Bet: Under 56 (-110)