If you are looking for the best NFL Week 10 odds and predictions, we have you covered with a comprehensive look at the opening odds for this week. Our predictions will cover every traditional NFL wager type at NFL betting sites, including the point spread, moneyline, and Over-Under.
The NFL Week 10 slate features 14 matchups. It begins in Chicago, Illinois, as the Carolina Panthers head to Soldier Field for Thursday Night Football against the Chicago Bears.
Additionally, you can also check out our highly successful NFL A.I. picks for Week 10 as well. Let’s dive into the NFL Week 10 odds from the best sports betting sites and make some winning bets.
The following NFL Week 10 betting odds are courtesy of Bovada:
Carolina Panthers vs. Chicago Bears Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Carolina Panthers | +2 (-110) | +115 | Over 41 (-110) |
| Chicago Bears | -2 (-110) | -135 | Under 41 (-110) |
Bryce Young needed to wait seven games for his first NFL win. It wasn’t pretty, but the Panthers edged out the Houston Texans for a 15-13 win in Week 8.
Now, he is searching for his first win on the road following a 27-13 loss to the Colts in Week 9. With Justin Fields back at practice and heading toward a start in Week 10, it’s not looking great, though.
The last time Fields played a full game, the Bears were at their best with a 40-20 win over the Washington Commanders.
If Fields is healthy, expect him and D.J. Moore to connect frequently. As a small favorite, the Bears are worth considering at home.
Panthers vs. Bears Prediction:
- Point Spread Bet: Chicago Bears -2 (-110)
- Moneyline Bet: Chicago Bears (-135)
- Over-Under Bet: Under 41 (-110)
Indianapolis Colts vs. New England Patriots Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Indianapolis Colts | -2 (-110) | -135 | Over 43.5 (-110) |
| New England Patriots | +2 (-110) | +115 | Under 43.5 (-110) |
Barring a miraculous reversal, the Patriots will miss the playoffs for the third time in four seasons. That said, some players have a lot to play for in the second half of the season.
QB Mac Jones is the most notable Patriot who is under a microscope. At least for Week 10, Jones should be in fine shape against a spotty Colts’ secondary.
The defense hasn’t been the primary issue for the Patriots. They should give QB Gardner Minshew a tough game in Germany. The edge goes to the Patriots over the Colts.
Colts vs. Patriots Prediction:
- Point Spread Bet: New England Patriots +2 (-110)
- Moneyline Bet: New England Patriots (+115)
- Over-Under Bet: Under 43.5 (-110)
Cleveland Browns vs. Baltimore Ravens Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Cleveland Browns | +5.5 (-110) | +195 | Over 40.5 (-110) |
| Baltimore Ravens | -5.5 (-110) | -235 | Under 40.5 (-110) |
Deshaun Watson and Lamar Jackson square off in what should be an entertaining battle at M&T Bank Stadium in Baltimore, Maryland. Although much of the attention will be on the quarterbacks, it’s the defenses that will decide this matchup.
The Browns and Ravens have aggressive defenses that like to get after the QB. Neither defense has allowed opposing QBs to get comfortable this season.
In a matchup that should develop into a defensive competition, you have to consider taking a look at the points. The Browns’ defense should be able to keep this one close.
Expect the Ravens to prevail by three or four points, but the Browns keep it close and cover the spread.
Browns vs. Ravens Prediction:
- Point Spread Bet: Cleveland Browns +5.5 (-110)
- Moneyline Bet: Baltimore Ravens (-235)
- Over-Under Bet: Under 40.5 (-110)
Houston Texans vs. Cincinnati Bengals Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Houston Texans | +7.5 (-110) | +280 | Over 44.5 (-110) |
| Cincinnati Bengals | -7.5 (-110) | -360 | Under 44.5 (-110) |
The Bengals are coming off a hard-fought 24-18 win against the Buffalo Bills. They’ve had it tough over the past three weeks, with games against the Seattle Seahawks, San Francisco 49ers, and now, the Bills.
While the Texans are on the rise under rookie QB C.J. Stroud, they represent a reversion in talent compared to Cincy’s most recent opponents. This would typically be seen as a positive, but the Bengals could very well overlook the Texans after such competitive games.
The Bengals should get away with a win over Houston. However, 7.5 points is a touch too high in what should be a game that’s closer than expected.
Texans vs. Bengals Prediction:
- Point Spread Bet: Houston Texans +7.5 (-110)
- Moneyline Bet: Cincinnati Bengals (-360)
- Over-Under Bet: Over 44.5 (-110)
New Orleans Saints vs. Minnesota Vikings Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| New Orleans Saints | -2.5 (-110) | -135 | Over 41 (-110) |
| Minnesota Vikings | +2.5 (-110) | +115 | Under 41 (-110) |
The Vikings return home for their first game since a 22-17 win over the 49ers on October 23. A lot has changed since then. Kirk Cousins is out for the season with a torn Achilles tendon.
Rookie QB Jaren Hall was next in line for the Vikings’ starting job. Unfortunately, in his first start, Hall left the game with a concussion. The newly-acquired Josh Dobbs took over and led the Vikings to a 31-28 victory.
Look for the Vikings to keep things simple at home against the Saints. The defense has surprisingly held its own and been a bright spot for the Vikings.
Expect the Vikings to lean on their defense versus a Saints’ offense without a clear identity. The Vikings as a home underdog is the play.
Saints vs. Vikings Prediction:
- Point Spread Bet: Minnesota Vikings +2.5 (-110)
- Moneyline Bet: Minnesota Vikings (+115)
- Over-Under Bet: Under 41 (-110)
San Francisco 49ers vs. Jacksonville Jaguars Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| San Francisco 49ers | -2.5 (-115) | -135 | Over 44.5 (-110) |
| Jacksonville Jaguars | +2.5 (-105) | +115 | Under 44.5 (-110) |
The 49ers are coming off a much-needed bye week in Week 9. They are on the heels of three straight losses against the Browns, Vikings, and Bengals.
The Jaguars had their bye week in Week 9, too. On a five-game winning streak, the Jaguars did not want to see their momentum potentially stopped.
Deebo Samuel, who plays a critical role in the 49ers’ offense, is expected back for the first time since October 15.
Expect a determined 49ers’ squad to get back on track with a win and cover over the Jags.
49ers vs. Jaguars Prediction:
- Point Spread Bet: San Francisco 49ers -2.5 (-115)
- Moneyline Bet: San Francisco 49ers (-135)
- Over-Under Bet: Under 44.5 (-110)
Atlanta Falcons vs. Arizona Cardinals Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Atlanta Falcons | -2.5 (-110) | -125 | Over 41 (-110) |
| Arizona Cardinals | +2.5 (-110) | +105 | Under 41 (-110) |
After a demoralizing 27-0 loss on the road at Cleveland, the Cardinals gear up for what could be Kyler Murray’s first start of the season. If Murray isn’t activated off the PUP list, he’ll have to miss the rest of the season.
The Falcons are an inconsistent team that can’t be trusted as a road favorite. Whether it’s Murray or Clayton Tune, this should be a low-scoring, closely contested matchup at State Farm Stadium.
As a small underdog, the right side appears to be on the Cardinals at home.
Falcons vs. Cardinals Prediction:
- Point Spread Bet: Arizona Cardinals +2.5 (-110)
- Moneyline Bet: Arizona Cardinals (+105)
- Over-Under Bet: Under 41 (-110)
Tennessee Titans vs. Tampa Bay Buccaneers Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Tennessee Titans | +1.5 (-110) | -105 | Over 38 (-110) |
| Tampa Bay Buccaneers | -1.5 (-110) | -115 | Under 38 (-110) |
With Ryan Tannehill expected to be cleared to return in Week 10, head coach Mike Vrabel has a decision to make regarding his starting QB. Will Levis has shown enough in two starts to warrant more game time.
He has superior arm strength, but Vrabel might be inclined to go with the safer option in Tannehill. If the Buccaneers’ secondary continues to play poorly, it may not matter who is under center.
As Derrick Henry runs well, the Titans will have opportunities to open up the passing game. The extra time off after a 20-16 loss to the Steelers on Thursday night should help with their prep work for the Bucs.
Titans vs. Buccaneers Prediction:
- Point Spread Bet: Tennessee Titans +1.5 (-110)
- Moneyline Bet: Tennessee Titans (-105)
- Over-Under Bet: Over 38 (-110)
Green Bay Packers vs. Pittsburgh Steelers Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Green Bay Packers | +3.5 (-115) | +140 | Over 37.5 (-110) |
| Pittsburgh Steelers | -3.5 (-105) | -160 | Under 37.5 (-110) |
Two of the most storied franchises in NFL history are set to meet in Pittsburgh. It should be a classic defensive showdown between the Packers and Steelers at Acrisure Stadium.
Despite winning last week, and a 5-3 start to the season, not everyone is happy in Pittsburgh. Talented wide receiver George Pickens is taking a page out of Davante Adams’ playbook and getting visibly frustrated over his lack of targets.
With the QB matchup between Jordan Love and Kenny Pickett evenly matched, there isn’t much that separates the Packers and Steelers. In what should be a field goal game, the Packers at +3.5 is the best pick.
Packers vs. Steelers Prediction:
- Point Spread Bet: Green Bay Packers +3.5 (-115)
- Moneyline Bet: Green Bay Packers (+140)
- Over-Under Bet: Under 37.5 (-110)
Detroit Lions vs. Los Angeles Chargers Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Detroit Lions | pk (-110) | -110 | Over 48.5 (-110) |
| Los Angeles Chargers | pk (-110) | -110 | Under 48.5 (-110) |
The Lions head to Los Angeles, California, for a marquee matchup at SoFi Stadium. They are coming off a bye week, while the Chargers have one less day to prepare after appearing on Monday Night Football on the road against the Jets.
There are similarities between the Lions and Chargers offensively. However, the Lions have much more to offer on defense. Aidan Hutchinson and the Lions should put the Chargers in uncomfortable situations.
The Chargers’ secondary is amongst the worst in the NFL. Amon-Ra St. Brown and company should find room to operate in a soft secondary.
Lions vs. Chargers Prediction:
- Point Spread Bet: Detroit Lions pk (-110)
- Moneyline Bet: Detroit Lions (-110)
- Over-Under Bet: Over 48.5 (-110)
New York Giants vs. Dallas Cowboys Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| New York Giants | +14.5 (-110) | +625 | Over 41.5 (-110) |
| Dallas Cowboys | -14.5 (-110) | -950 | Under 41.5 (-110) |
The Cowboys return home following a tough matchup against the Eagles in Philadelphia, Pennsylvania. They are by far the superior team over the Giants, but will they be fully engaged in Week 10?
Probably not, but it likely won’t matter given the current status of the Giants. QB Daniel Jones returned to the field last week, but left against the Raiders with a knee injury.
With backup Tyrod Taylor out, third-team QB Tommy DeVito entered the game and he couldn’t move the offense.
The Cowboys might go through the motions. That said, it should be enough to pull away from a dysfunctional Giants’ offense for a double-digit win.
Giants vs. Cowboys Prediction:
- Point Spread Bet: Dallas Cowboys -14.5 (-110)
- Moneyline Bet: Dallas Cowboys (-950)
- Over-Under Bet: Under 41.5 (-110)
Washington Commanders vs. Seattle Seahawks Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Washington Commanders | +6 (-110) | +220 | Over 44.5 (-110) |
| Seattle Seahawks | -6 (-110) | -270 | Under 44.5 (-110) |
On Sunday, the Seahawks were outworked and embarrassed for a 37-3 loss at Baltimore. Despite the ugly performance, the Seahawks should be in much better shape at home versus the Commanders.
The Commanders are coming off a physical 20-17 win over the Patriots in Foxborough. The defense finally stepped up and got a big stop when they needed it the most.
That hasn’t been typical for the Commanders. Look for Geno Smith to get into a rhythm and put the ball into the end zone consistently. The Seahawks should win and cover by 8 to 13 points.
Commanders vs. Seahawks Prediction:
- Point Spread Bet: Seattle Seahawks -6 (-110)
- Moneyline Bet: Seattle Seahawks (-270)
- Over-Under Bet: Over 44.5 (-110)
New York Jets vs. Las Vegas Raiders Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| New York Jets | -2.5 (-110) | -135 | Over 37 (-110) |
| Las Vegas Raiders | +2.5 (-110) | +115 | Under 37 (-110) |
The Jets travel to Las Vegas for a matchup against the rejuvenated Raiders for Sunday Night Football. In Antonio Pierce’s first game as head coach, the Raiders finally looked alive in a blowout of the Giants.
Aidan O’Connell and the Raiders will not cut through the Jets’ defense as easily this week. However, laying points on Zach Wilson on the road isn’t the best value.
This appears like a defensive game that could come down to a last-second field goal. Consider taking the points on the home underdog at football betting sites.
Jets vs. Raiders Prediction:
- Point Spread Bet: Las Vegas Raiders +2.5 (-110)
- Moneyline Bet: Las Vegas Raiders (+115)
- Over-Under Bet: Under 37 (-110)
Denver Broncos vs. Buffalo Bills Odds
| TEAM | SPREAD | MONEYLINE | TOTAL |
|---|---|---|---|
| Denver Broncos | +8.5 (-110) | +340 | Over 46 (-110) |
| Buffalo Bills | -8.5 (-110) | -460 | Under 46 (-110) |
The Broncos went into the bye week with their heads held high. They knocked off the Kansas City Chiefs in unlikely fashion by a score of 24-9 at Mile High Stadium.
It’s the biggest win of Russell Wilson’s two-year career in Denver and much-needed as far as the playoffs are concerned. The win gives the Broncos some life for a wildcard in the AFC.
They are not expected to get closer to the playoffs with a win over the Bills. However, this point spread is too inflated at eight points. The Broncos lose, but get the cover in Orchard Park, New York.
Broncos vs. Bills Prediction:
- Point Spread Bet: Denver Broncos +8.5 (-110)
- Moneyline Bet: Buffalo Bills (-460)
- Over-Under Bet: Over 46 (-110)
NFL Week 10 Best Bet
The 49ers return from their break with an important game ahead of them in Jacksonville at EverBank Stadium. After jumping out to a 5-0 start through the first five weeks, the 49ers are suddenly 5-3 and have the same record as the Seahawks in the NFC West.
The offense has looked disjointed without Christian McCaffrey and Samuel on the field together.
However, when they’ve been active, the 49ers’ offense has been one of the best units in the league.
More than anybody, Brock Purdy will appreciate Samuel being on the field against the Jaguars. Purdy is a different QB when he has the luxury of dumping the ball off to his favorite receiver and letting him run.
Prior to the Jaguars going on their bye in Week 9, they managed to beat the Steelers with their defense in a 20-10 win. Trevor Lawrence will be asked to come up with an extra play or two to defeat the 49ers.
Following an iffy performance versus the Bengals, expect the 49ers’ defense to respond off the bye week. This should be a fully focused and well-prepared 49ers team in Week 10.
For our NFL Week 10 best bet, the 49ers as short favorites over the Jaguars is locked in at Bovada.
Best NFL Week 10 Parlay
To wrap up our card, we are diving into parlay betting with our best ticket for Week 10. Parlays should not be your primary NFL bet, but throwing a couple of parlay tickets together can be financially rewarding.
For the best NFL parlay payouts, we recommend playing your tickets at Bovada. We have a five-team NFL Week 10 parlay locked in, and it has the potential for a big payout on a $100 wager.
The following five-team parlay has the potential to profit $1,471.86 for a winning ticket:
- San Francisco 49ers (-135)
- Minnesota Vikings (+115)
- Baltimore Ravens (-235)
- Seattle Seahawks (-270)
- Las Vegas Raiders (+115)
