2025 NFL Week 11 Betting Preview: Odds, Lines, and Best Bets

The NFL Week 11 odds are headlined by the first-ever regular-season contest from Madrid! The schedule is also packed with divisional contests, so it should be a fun week of football action.

Keep reading to see the latest odds and betting lines for Week 11, as well as my best bets for all games.

2025 NFL Week 11 Odds and Betting Lines (Snapshot)

See the table below for the latest NFL Week 11 betting lines, courtesy of Bovada.

The Patriots are the biggest favorites of the week at NFL betting sites, as the bookies have set the spread at -11.5 against the Jets on Thursday Night Football. The Texans (-7) and the Ravens (-8) are also heavy favorites against the Titans and the Browns, respectively.

The first Madrid game in NFL history is scheduled for Sunday. Washington (3-7) takes on Miami (3-7) as both teams search for their fourth win of the year. The Dolphins are 3-point favorites against a Commanders’ team that will be without multiple starters, including QB Jayden Daniels.

Two teams, the Indianapolis Colts and the New Orleans Saints, are on a bye this weekend.

Check the latest odds and wager on your best bets by going to Bovada and navigating to Sports > Football > NFL > NFL Week 11.

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New York Jets vs. New England Patriots Preview: Odds, Betting Lines, Best Bets

The Patriots edged out the Buccaneers in Tampa Bay last week to keep their strong unbeaten run alive. New England will now put a seven-game winning streak on the line on Thursday Night Football against the Jets (2-7), who have won back-to-back games.

Divisional matchups, especially on short weeks, can be tough to predict. Despite that, the Pats are still 11.5-point favorites in this AFC East divisional showdown.

Adding to the pressure for New England is the fact that they will be debuting new uniforms. Teams are 1-2 so far this season when making their debut in their Rivalry uniforms. More importantly, the short rest ahead of TNF games has had a major impact on favorites this season.

Three underdogs have won outright against divisional opponents this season. I would not bet on the Jets to win this game, but they should keep it closer than the spread. New England has only averaged 25 PPG at home this season, compared to 28 PPG on the road. That decrease in scoring could be the difference in covering this week or not. The Pats will extend their winning streak to eight games, but they should struggle to cover the spread.

Washington Commanders vs. Miami Dolphins Preview: Odds, Betting Lines, Best Bets

The first-ever regular-season matchup in Madrid, Spain, features two 3-7 teams fighting to save their seasons. Miami, the designated home team, is coming off a major win over the Bills last week.

Washington, on the other hand, were on the losing end of a 44-22 blowout against the Lions. It was the Commanders’ fifth consecutive loss, and their fourth straight loss by 21+ points.

Miami has won two of its last three games. The Dolphins are favored by a field goal this week in Madrid.

De’Von Achane racked up 225 scrimmage yards against the Bills, including 174 rushing yards. The Commanders allowed Detroit to gain 226 yards on the ground on just 33 carries. If Achane sees a similar workload in Madrid, he will carry the Dolphins to a win.

Carolina Panthers vs. Atlanta Falcons Preview: Odds, Betting Lines, Best Bets

Carolina secured the first shutout win of the 2025 season with its 30-0 upset of the Falcons in Week 3. It has not been an easy road since then, but the Panthers have climbed their way to a 5-5 record and are currently second in the NFC South.

Atlanta’s season has fallen completely off the rails recently. The Falcons are 3-6 and have lost four straight games. They are at a significant rest disadvantage, too, as the Falcons played in Berlin last weekend.

Despite that, the Falcons are 3.5-point home favorites in this contest. Atlanta allowed Jonathan Taylor to gain 286 total yards and three TDs last week. Taylor had 244 rushing yards, including the longest run in the NFL this season, an 83-yard score in the fourth quarter.

Carolina’s rushing attack is the key to their success on offense this year. If the Panthers can exploit the same holes that the Colts did, they can upset the Falcons again and secure the regular-season sweep.

Tampa Bay Buccaneers vs. Buffalo Bills Preview: Odds, Betting Lines, Best Bets

Miami secured its third win of the season on MNF with its 23-15 win over the Rams in SoFi. The  Dolphins ofThe Bucs and Bills both suffered potentially costly losses last week. Tampa Bay fell 28-23 at home to the Patriots, while Buffalo was blown out 30-13 by the Dolphins.

Buffalo was shut out for the first three quarters of its loss last week. Despite coming off their worst game of the season, Josh Allen and the Bills are 5.5-point favorites against the Buccaneers this week.

The Bills are 4-1 at home this season, but Tampa Bay is 4-1 on the road. This game will be decided by which offense can bounce back from their poor showing last week.

The Bucs have been held to 23 or fewer points in three straight games. Tampa’s struggles are mainly due to injuries, especially on offense. Unfortunately, that means fixing their shortcomings will be easier said than done.

With that in mind, I think the Bucs will struggle again this week against a Bills’ team looking to keep pace with the Pats for first place in the AFC East. Buffalo should win, but I don’t expect them to cover the spread.

Los Angeles Chargers vs. Jacksonville Jaguars Preview: Odds, Betting Lines, Best Bets

The Chargers’ offense struggled early in the SNF win, but LA’s defense shut down the Steelers en route to a 25-10 prime-time victory. Jacksonville, conversely, had a 29-10 lead before allowing 26 unanswered points in the fourth quarter and losing to Houston.

With the defeat, the Jags jeopardized their chances of winning the AFC South. Jacksonville has lost three of its last four games, and the only exception during that stretch was a 30-29 OT win over Las Vegas.

The Chargers are 3-point road favorites in this clash of second-place AFC teams.

Los Angeles struggled to find their footing against the Steelers’ defense. Jacksonville’s defense, apart from the fourth quarter last week, is one of the better units in the league this season. The Jags have forced 17 turnovers and have a +8 turnover differential, both of which rank second in the league.

Chargers’ QB Justin Herbert has been sacked 11 times in the last two games, and he has thrown eight INTs this year. If Jacksonville’s defense can capitalize on Herbert’s struggles, they can pull off the upset. However, I think LA will take a run-heavy approach to minimize that risk, and the Chargers will win this game.

Chicago Bears vs. Minnesota Vikings Preview: Odds, Betting Lines, Best Bets

Chicago was one quarter away from a dominant win over Minnesota in Week 1. Unfortunately for Bears’ fans, the team could not seal the deal and gave up 21 unanswered points in the 27-24 loss.

On the bright side, the Bears have rebounded from their tough start, winning six of their last seven games to earn a 6-3 record. Minnesota, without J.J. McCarthy for most of the season, is just 4-5 heading into this divisional contest.

The Vikings have lost three of their last four games and are just 1-3 at home this season. Their only win at home came against the Bengals in Week 3. However, Minnesota are the 3-point favorites in this NFC North matchup.

McCarthy has been inconsistent, to say the least, this season, but he is 2-2 as a starter. Minnesota’s defense has struggled recently, allowing 24+ points in four straight games. They have also forced just nine total turnovers, tied for the eighth-fewest in the league.

That will struggle to get the job done against a Bears’ offense that is averaging nearly 380 YPG, the third-most in the NFL. Chicago should get the upset win and secure a season split against Minnesota on Sunday.

Cincinnati Bengals vs. Pittsburgh Steelers Preview: Odds, Betting Lines, Best Bets

Joe Burrow returned to practice this week, but it will still be a while before the Bengals get their starting QB back. Cincinnati will turn to Joe Flacco again this week as they take on the Steelers in Pittsburgh.

Cincy had a bye last week, while the Steelers lost big in LA on SNF. Despite their recent ineptitude on both sides of the ball, the Steelers are 5.5-point favorites against the Bengals this weekend.

Pittsburgh’s offense has been, predictably, terrible with Aaron Rodgers under center. The Steelers are averaging 280 total YPG, including under 200 passing yards and just over 85 YPG on the ground. Pittsburgh’s 23.6 PPG is ranked 16th in the league.

Adding to the Steelers’ woes is the fact that they have lost three of their last four, all but squandering their lead in the AFC North division race.

Flacco and Ja’Marr Chase lit up the Steelers’ defense on TNF in Week 7. It should be a similar outcome this time around, with Chase leading the way for the Bengals to sweep the Steelers this season. in this game and improve to 8-2 on the year.

Houston Texans vs. Tennessee Titans Preview: Odds, Betting Lines, Best Bets

Another AFC divisional matchup on this week’s schedule pits the Texans (4-5) against the Titans (1-8) in Tennessee. Houston shut out Tennessee 26-0 when these teams met in Week 4.

Tennessee had a bye in Week 10, but the extra rest was not enough to sway the odds in their favor. The Titans are 7-point home underdogs for this AFC South matchup. The Texans are -360 moneyline favorites in this game.

A win would lift the Texans to a .500 record for the first time this season, and they’re in a good position to achieve it.

The Titans’ defense has not held an opponent under 20 points all season. Tennessee’s offense, conversely, has scored more than 20 points just once. Houston’s offense has also struggled, managing just 22.7 PPG, but the Texans’ defense allows a league-low 16.7 PPG.

Houston’s starting QB for this game is up in the air as CJ Stroud continues to work through the NFL concussion protocol. Even if Stroud has to miss another week, the Texans have enough weapons to dominate the Titans wire-to-wire this weekend. Houston should win and cover the touchdown spread.

San Francisco 49ers vs. Arizona Cardinals Preview: Odds, Betting Lines, Best Bets

San Francisco and Arizona, both on the losing end of NFC West matchups last week, square off this week in Glendale. The Cardinals, led by Jacoby Brissett, are 2.5-point underdogs at home for this game.

Despite losing in a blowout, Mac Jones posted another 300+ passing yards for the 49ers last week. Christian McCaffrey had 96 total yards, including 66 through the air on 10 targets.

McCaffrey figures to be a big part of the game plan again this week. One thing that is uncertain, though, is who the 49ers will be starting at QB. Jones is 5-3 as a starter, but Brock Purdy could return from injury this week.

Regardless of who their QB is, the 49ers offense should be able to outpace the Cards this weekend. Arizona has lost six of the last seven games. The Cards have also allowed 27+ points in three of their last four games.

Arizona’s offense has been better since Brissett took over for Kyler Murray, but he has only managed one win in his four starts. The Cards will simply be outmatched this weekend, and McCaffrey should power the 49ers to an important road divisional win.

Seattle Seahawks vs. Los Angeles Rams Preview: Odds, Betting Lines, Best Bets

The other NFC West teams will also face off this week, as the Rams (7-2) host the Seahawks (7-2) at SoFi with first place in the division on the line.

The Rams are 3-point home favorites in this crucial NFC West showdown. Seattle are +135 moneyline underdogs.

Both teams scored 40+ points in blowout wins last week. However, Sam Darnold turned the ball over multiple times, leading directly to points for Arizona. If that happens again this week, the Seahawks will be in trouble.

LA is 3-1 at home this year. Seattle, however, is undefeated on the road in 2025. Dating back to last season, the Seahawks have won 10 consecutive road games.

Matthew Stafford has had to play at an MVP level to keep the Rams’ winning streak going. Seattle’s defense should put an end to Stafford’s high production this week. Winning the turnover battle will be key, but I believe Darnold and the Seahawks will get the job done in LA.

Baltimore Ravens vs. Cleveland Browns Preview: Odds, Betting Lines, Best Bets

The Ravens look to continue their winning streak this week with a matchup against the Cleveland Browns. Baltimore started 1-5, but the Ravens have won three straight games to get within striking distance of a .500 record.

Lamar Jackson and the Ravens are 8-point road favorites against the Browns in Cleveland.

On paper, this should be an easy win for the Ravens against the 2-7 Browns. However, recent history suggests that it will not be that easy.

Cleveland has split with Baltimore each of the last four years. Also, the Browns have won three of their last four matchups against the Ravens in Cleveland.

To keep their streak against the Ravens going this week, the Browns need their defense to step up at home. Both of the Browns’ wins this season have come at home when they have held opponents to 10 points or fewer.

Shutting down a white-hot Baltimore offense will not be easy. That being said, I do think the Browns can cover the spread at home this week.

Kansas City Chiefs vs. Denver Broncos Preview: Odds, Betting Lines, Best Bets

Denver’s defense is outstanding, but the offense struggled in a 10-7 win over the Raiders on TNF last week. Their offensive issues are a big reason why the Broncos (8-2) are 3.5-point underdogs at home against the Chiefs (5-4) this week.

The Broncos and Chiefs have the third- and fourth-best scoring defenses, allowing just 17.3 and 17.7 PPG, respectively. KC’s offense, though, is averaging 26.1 PPG to Denver’s 23.5.

Denver’s offense has been especially bad in its last two games, totaling just 28 points against the Texans and the Raiders. They have been held to 20 points or fewer in five games this season.

If Bo Nix’s struggles continue, the Broncos’ seven-game winning streak will end this weekend. KC had a bye to prepare for this game. Also, since Rashee Rice and Xavier Worthy returned to the lineup, the Chiefs’ offense has improved. Patrick Mahomes and company need to win this game to keep their AFC West division hopes alive, and I expect a strong performance from them.

Dallas Cowboys vs. Las Vegas Raiders Preview: Odds, Betting Lines, Best Bets

Dallas lost on Monday Night Football in Week 9 and had a bye last week. The Cowboys are back on MNF this week, taking on the Raiders in Las Vegas. The Raiders had a mini-bye to prepare for this game after losing 10-7 on TNF last week.

Las Vegas is a 3.5-point home underdog for this prime-time contest.

The Cowboys’ defense has allowed 30.8 PPG this season, the second-most in the NFL. They are the perfect remedy for a Las Vegas offense that has struggled more often than not this season.

Brock Bowers is back and has had multiple games to get into football shape. Ashton Jeanty is also in line for a good game against a Dallas team that allowed over 140 rushing YPG in their first nine games.

Dallas did trade for Quinnen Williams at the deadline to help solidify their run defense. This will be Williams’ debut for the Cowboys, and he should make an impact. However, Williams alone will not be enough to prevent the Raiders from pulling off the upset in primetime.

Green Bay Packers vs. New York Giants Preview: Odds, Betting Lines, Best Bets

The Packers’ defense showed up big on MNF last week, holding the Eagles to just 10 points. Unfortunately, Green Bay’s offense could only put together one scoring drive, and the Packers lost 10-7 at home.

All three of the Packers’ losses this season have come in games where the defense allowed 16 points or fewer.

Despite that alarming trend, Green Bay are 7-point road favorites against the Giants this weekend. New York fired their coach and elevated Jameis Winston to the starting QB role to replace the injured Jaxson Dart.

For better or worse, anything is possible with Winston as your QB. Making a coach change can also provide a spark for struggling teams. Defenses usually travel well, so I expect the Packers to win this game against a Giants team that is riddled with offensive injuries. However, Jameis is famous for a reason, and he can help the Giants cover the 7-point spread on Sunday.

Detroit Lions vs. Philadelphia Eagles Preview: Odds, Betting Lines, Best Bets

This week’s Sunday Night Football matchup has the makings of one of the best games of the season. Detroit (6-3) heads to Philadelphia to take on the Eagles (7-2) in a game between top NFC teams.

The Eagles are ahead by a field goal in this prime-time matchup. Philadelphia’s defense had a rough start to the year, but it has turned its season around. The Eagles have held four of their last five opponents to 22 points or fewer. Philly’s defense will have to be at its best to slow down the Lions, who averaged 31.4 PPG, the second-most points in the league.

Detroit’s hopes of pulling off the upset ride entirely on the offensive line. If the Lions can keep Jared Goff upright, he can distribute the ball to Detroit’s playmakers and allow them to win the game. Goff is not great when he is pressured, though, and the Lions’ game plan could go in the trash if the Eagles’ D-Line controls the line of scrimmage.

The Lions have struggled with consistency this year, especially against the top teams in prime time. That should be the case again this weekend, as the Eagles’ front seven can wreck the game and secure the win for Philly.

Where to Find NFL Week 11 Odds and Betting Lines?

The best place to bet on your Week 11 best bets is Bovada. It provides competitive lines for all 15 Week 11 games, including prime-time matchups and the first-ever Madrid game.

As a new member at Bovada, you can use the code BV1000 to get a 50% deposit match on your first deposit. The bonus is worth up to $1,000 in bonus funds that you can use to wager on your best bets for Week 11.

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