2023 NFL Week 6 Odds and Predictions

Jaguars Colts Odds

The action is heating up with the 2023-24 season at NFL betting sites. We are dissecting the opening NFL Week 6 odds and making picks for every matchup on the board. Including NFL Week 6 predictions against the spread, we have moneyline and Over-Under picks to shar.

The Green Bay Packers and Pittsburgh Steelers are the only teams that won’t be on the field in Week 6. While they take their bye weeks, 15 games are scheduled to be played.

This week begins in Kansas City, Missouri, as the Denver Broncos face the Kansas City Chiefs at Arrowhead Stadium on Thursday Night Football. Let’s delve into the latest odds and lock in our early NFL Week 6 predictions at sports betting sites. Check out our A.I. NFL picks for even more NFL Week 6 betting picks.

The following NFL Week 6 odds are courtesy of Bovada:

Denver Broncos vs. Kansas City Chiefs Odds

Denver Broncos+10 (-105)+370Over 50.5 (-110)
Kansas City Chiefs-10 (-115)-510Under 50.5 (-110)

Last week, the Broncos were at home versus the Jets. They have a much taller task to open Week 6 on Thursday Night Football.

Russell Wilson will be seeking a big upset against Patrick Mahomes and the Chiefs at Arrowhead in primetime. The Chiefs’ offense has been inconsistent through the opening stretch of the season.

They have been running hot and cold on both sides of the ball. This does not look like a championship defense, nor is the offense at its peak potential.

However, the Broncos should be a target for the Chiefs to dominate in primetime. That has been the case in this AFC West series, as the Chiefs have won 15 straight times over the Broncos.

Broncos vs. Chiefs Prediction:

  • Point Spread Bet: Kansas City Chiefs -10 (-115)
  • Moneyline Bet: Kansas City Chiefs (-510)
  • Over-Under Bet: Over 50.5 (-110)

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Baltimore Ravens vs. Tennessee Titans Odds

Baltimore Ravens-4 (-110)-195Over 40.5 (-110)
Tennessee Titans+4 (-110)+165Under 40.5 (-110)

The Ravens are coming off a hard-nosed rivalry game on the road at Pittsburgh. They remain on the road, heading over the pond for the Week 6 London game against the Titans.

At times, Baltimore has looked like a serious contender to win the AFC and advance to Super Bowl 58. Unfortunately, there are other times where they look wildly inconsistent and would be fortunate to even make the Playoffs.

The Titans haven’t excelled against the pass, but their ability to stop the run should come in handy against the Ravens.

We are calling for a field goal game. The points on the underdog is probably where you should look in London at Tottenham Hotspur Stadium.

Ravens vs. Titans Prediction:

  • Point Spread Bet: Tennessee Titans +4 (-110)
  • Moneyline Bet: Tennessee Titans (+165)
  • Over-Under Bet: Under 40.5 (-110)

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Washington Commanders vs. Atlanta Falcons Odds

Washington Commanders+1.5 (-110)+105Over 41.5 (-110)
Atlanta Falcons-1.5 (-110)-125Under 41.5 (-110)

The Commanders are among the most difficult teams to figure out in the NFL. Which team shows up after getting embarrassed by the Bears in primetime?

They’ve had extra time to prepare, but their defense doesn’t evoke much confidence on the road.

The Falcons have not been an attractive-looking football team lately. However, they should be able to lean on Bijan Robinson and Tyler Allgeier to win an ugly football game at home.

Commanders vs. Falcons Prediction:

  • Point Spread Bet: Atlanta Falcons -1.5 (-110)
  • Moneyline Bet: Atlanta Falcons (-125)
  • Over-Under Bet: Under 41.5 (-110)

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Indianapolis Colts vs. Jacksonville Jaguars Odds

Indianapolis Colts+4.5 (-110)+180Over 45.5 (-110)
Jacksonville Jaguars-4.5 (-110)-220Under 45.5 (-110)

The Colts are prepared to start former Jaguars’ QB Gardner Minshew in place of the injured Anthony Richardson. Minshew won some big games for the Jaguars during his time in Jacksonville from 2019 to 2020.

Now, Minshew can put the Colts up in the AFC South with a win over the Jaguars. Expect Minshew to be motivated on his return trip to Jacksonville.

Coming home from London with a big win in their back pocket, the Jaguars might be slightly lethargic in this divisional showdown. The Jags should pull it out, but the Colts will put up a fight.

Colts vs. Jaguars Prediction:

  • Point Spread Bet: Indianapolis Colts +4.5 (-110)
  • Moneyline Bet: Jacksonville Jaguars (-220)
  • Over-Under Bet: Under 45.5 (-110)

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Minnesota Vikings vs. Chicago Bears Odds

Minnesota Vikings-3 (-110)-165Over 48 (-110)
Chicago Bears+3 (-110)+140Under 48 (-110)

Despite an eye-opening 40-20 win over the Commanders, the Bears are dealing with a plethora of injuries. They were down several starters, and even second-time players, on both sides of the ball.

The Bears have had extra time to prepare for Week 6, but still have injuries to contend with in Week 6. However, the Vikings could be without star wide receiver Justin Jefferson.

Jefferson is the focal point of the Vikings’ offense. The field opens up for Kirk Cousins with Jefferson on the field. If he can’t start, the Vikings will be severely hampered offensively.

That puts the ball squarely in the Bears’ court at home. Justin Fields should have the upper hand with D.J. Moore over a Jefferson-less Vikings squad. Of course, pay attention to the injury report for this one.

Vikings vs. Bears Prediction:

  • Point Spread Bet: Chicago Bears +3 (-110)
  • Moneyline Bet: Chicago Bears (+140)
  • Over-Under Bet: Over 48 (-110)

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San Francisco 49ers vs. Cleveland Browns Odds

San Francisco 49ers-4 5 (-110)-210Over 41.5 (-110)
Cleveland Browns+4.5 (-110)+185Under 41.5 (-110)

The 49ers are expected to be one of the biggest public bets from the NFL Week 6 odds at football betting sites.

Following a marquee matchup against the Cowboys on Sunday Night Football, the 49ers could come out feeling a bit lethargic after flying east to Cleveland.

Deshaun Watson was unexpectedly scratched leading up to game time against the Ravens two weeks ago. He is expected to be ready after the bye week.

While the 49ers were focused on the Cowboys, the Browns have had two weeks to prepare for this matchup. Expect the Browns to stay within striking distance with their pass rush, while Watson returns to the field in decent form.

49ers vs. Browns Prediction:

  • Point Spread Bet: Cleveland Browns +4.5 (-110)
  • Moneyline Bet: San Francisco 49ers (-210)
  • Over-Under Bet: Under 41.5 (-110)

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Seattle Seahawks vs. Cincinnati Bengals Odds

Seattle Seahawks+3 (-115)+135Over 45.5 (-110)
Cincinnati Bengals-3(-105)-160Under 45.5 (-110)

Could the win at Arizona spark a run for the Bengals? While it wasn’t perfect, Joe Burrow looked comfortable as he and Ja’Marr Chase were able to establish a rhythm.

However, it would be all for for nothing if the Bengals aren’t competitive at home against the Seahawks.

Burrow looked sharp, but he still isn’t playing at 100 percent. The training staff had his calf wrapped on the side at times. Consider the Seahawks in a close contest.

Seahawks vs. Bengals Prediction:

  • Point Spread Bet: Seattle Seahawks +3 (-115)
  • Moneyline Bet: Seattle Seahawks (+135)
  • Over-Under Bet: Over 45.5 (-110)

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New Orleans Saints vs. Houston Texans Odds

New Orleans Saints-2 (-110)-135Under 41 (-110)
Houston Texans+2 (-110)+115Under 41 (-110)

The Saints are coming off an impressive 34-0 blowout win over the Patriots. Now, they head to Houston for a matchup against a Texans squad coming off a tough 21-19 loss at Atlanta.

It was a tough last-second loss for the Texans, and now they have a confident Saints’ defense to contend with at home. Additionally, Alvin Kamara’s return has provided the offense with a lift.

This is a matchup where the Texans would appreciate having a healthy offensive line. In their current form, it should be a tough assignment. Look for the Saints to hold on at NRG Stadium.

Saints vs. Texans Prediction:

  • Point Spread Bet: New Orleans Saints -2 (-110)
  • Moneyline Bet: New Orleans Saints (-135)
  • Over-Under Bet: Under 41 (-110)

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Carolina Panthers vs. Miami Dolphins Odds

Carolina Panthers+13.5 (-110)+525Over 48 (-120)
Miami Dolphins-13.5 (-110)-800Under 48 (+100)

Bryce Young would be better served sitting behind a veteran QB and learning. Unfortunately, as the first overall pick of the 2023 NFL Draft, Young does not have that luxury.

Frank Reich’s coaching staff isn’t doing him many favors with suspect play-calling. Nevertheless, Young has to be better at Miami. He might come up with some plays, but not enough to keep pace with Tua Tagovailoa.

In a battle of two recent Alabama QBs, Tagovailoa and the Dolphins pummel the Panthers. Carolina dropped a 42-24 decision to the Lions last week, and that looks about accurate for Week 6.

Panthers vs. Dolphins Prediction:

  • Point Spread Bet: Miami Dolphins -13.5 (-110)
  • Moneyline Bet: Miami Dolphins (-800)
  • Over-Under Bet: Over 48 (-120)

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New England Patriots vs. Las Vegas Raiders Odds

New England Patriots+1 (-110)-105Over 42 (-110)
Las Vegas Raiders-1 (-110)-115Under 42 (-110)

Bill Belichick and the Patriots have been known for breaking records. This season, it has been the wrong type of team records. The Patriots are off to a 1-4 start and coming off back-to-back blowouts.

Mac Jones is struggling mightily, and he doesn’t have the weapons to make up for his boneheaded decision-making. Furthermore, the defense isn’t anything that we come to expect from Belichick.

Look for Jimmy Garoppolo to kick his former team while they are down with a win at home in Las Vegas. There isn’t any reason to back a Patriots team making no effort to win games.

Patriots vs. Raiders Prediction:

  • Point Spread Bet: Las Vegas Raiders -1 (-110)
  • Moneyline Bet: Las Vegas Raiders (-115)
  • Over-Under Bet: Under 42 (-110)

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Detroit Lions vs. Tampa Bay Buccaneers Odds

Detroit Lions-3.5 (-105)-185Over 45.5 (-110)
Tampa Bay Buccaneers+3.5 (-115)+160Under 45.5 (-110)

The Buccaneers are coming off their bye week with a sizable challenge in the form of the Lions. The defense better have done their homework or the Lions could ring up the scoreboard in a hurry.

Baker Mayfield and the Buccaneers went into the break off a 26-9 win over the Saints. Derek Carr was held to just 127 passing yards. This was a nice response after a 25-11 loss to the Eagles on Monday Night Football.

The 3-1 Buccaneers will have their hands full, but expect them to bring this game down to the wire. The Bucs’ NFL Week 6 betting odds are a great value at plus points.

Lions vs. Buccaneers Prediction:

  • Point Spread Bet: Tampa Bay Buccaneers +3.5 (-115)
  • Moneyline Bet: Tampa Bay Buccaneers (+160)
  • Over-Under Bet: Under 45.5 (-110)

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Philadelphia Eagles vs. New York Jets Odds

Philadelphia Eagles-6 (-110)-250Over 42.5 (-110)
New York Jets+6 (-110)+210Under 42.5 (-110)

The Jets are back home to welcome the Eagles to town after a hard-fought road win in Denver. They defeated the Broncos, but the Eagles are a much different test.

On Sunday, expect the Eagles’ defense to smother Zach Wilson into submission. The Jets’ defense is better than advertised, but they aren’t going to win a defensive game versus the Eagles.

Look for the Eagles’ pass rush to assert their dominance over the Jets. They should pull away and win by at least a touchdown at MetLife Stadium.

Eagles vs. Jets Prediction:

  • Point Spread Bet: Philadelphia Eagles -6 (-110)
  • Moneyline Bet: Philadelphia Eagles (-250)
  • Over-Under Bet: Under 42.5 (-110)

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Arizona Cardinals vs. Los Angeles Rams Odds

Arizona Cardinals+5.5 (-110)+200Over 47 (-110)
Los Angeles Rams-5.5 (-110)-240Under 47 (-110)

The Cardinals’ confidence might have been shot after Dobbs threw a pick-6 moments after the defense stood up at the goal line. Joe Burrow and the Bengals seized the opportunity to pull away for a must-win in the desert.

Following a difficult matchup against the Eagles’ defense, the Cardinals will present a much easier challenge for Matthew Stafford and company.

The Cardinals had a nice Cinderella story to open the season, but they were likely playing above their heads. Expect the Rams to handle their business at home to win and cover.

Cardinals vs. Rams Prediction:

  • Point Spread Bet: Los Angeles Rams -5.5 (-110)
  • Moneyline Bet: Los Angeles Rams (-260)
  • Over-Under Bet: Over 47 (-110)

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New York Giants vs. Buffalo Bills Odds

New York Giants+15 (-110)+625Over 46 (-110)
Buffalo Bills+15 (-110)-1000Under 46 (-110)

The Bills are back on US soil in the wake of a disastrous trip to London. The Jaguars took advantage of a jet-lagged Bills squad for a 25-20 win.

The hapless Giants are the ideal opponent after a frustrating loss. On the heels of three straight double-digit losses, they are 15-point underdogs on the road. Oddsmakers are expecting a beatdown in Orchard Park.

Daniel Jones is scheduled to undergo an MRI for a neck injury. If Jones can’t start, Tyrod Taylor is up next. With Jones ineffective this season, Taylor may not be much of a downgrade.

The Giants are optimistic that Saquon Barkley can start after missing his third straight game. Bills’ linebacker Matt Milano and defensive tackle Daquan Jones left with injuries in London. Already without Tre’Davious White, the injuries on defense are adding up for the Bills.

If Barkley starts, the Giants should be able to grind out the clock on the ground. They aren’t winning, but they can cover an inflated point spread.

Giants vs. Bills Prediction:

  • Point Spread Bet: New York Giants +15 (-110)
  • Moneyline Bet: Buffalo Bills (-1000)
  • Over-Under Bet: Over 46 (-110)

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Dallas Cowboys vs. Los Angeles Chargers Odds

Dallas Cowboys-2 (-110)-140Over 47.5 (-110)
Los Angeles Chargers+2 (-110)+120Under 47.5 (-110)

The 49ers had the offensive line to hold up against a furious Cowboys’ pass rush. However, we are not as confident in the Chargers protecting Justin Herbert.

The Chargers are coming off a bye week, but the extra time off isn’t going to prepare them for Micah Parsons and the Cowboys’ defense.

Also, the Chargers’ secondary will prove to be a much simpler assignment than the 49ers. They are going from one of the best in the league to the worst.

The Chargers have conceded roughly 300 passing yards per game. Dak Prescott and CeeDee Lamb are set for bounce-back numbers on Monday Night Football in the Week 6 finale.

Cowboys vs. Chargers Prediction:

  • Point Spread Bet: Dallas Cowboys -2 (-110)
  • Moneyline Bet: Dallas Cowboys (-140)
  • Over-Under Bet: Over 47.5 (-110)

Place Your Bets Now!

NFL Week 6 Best Bet

The Panthers have conceded 100 points over the last three games. The Seahawks and Lions torched them for 37 and 42 points.

We do not foresee the Panthers showing any improvement against the most prolific offense in the NFL. Tagovailoa and the high-octane Dolphins’ attack will beat up the Panthers with Tyreek Hill and Jaylen Waddle in the secondary.

The Dolphins have scored at least 31 points in two home games. They regressed to 20 points at Buffalo after pouring it on for 70 points over the Broncos in Week 3. However, the offense picked up where they left off at Hard Rock Stadium.

The Panthers have gotten gashed against teams that can run the ball. Miami is capable of running it down their throats, and then opening up the passing game.

We like the Dolphins against the spread, but the Over is likely the safer bet. Bryce Young will be forced to air it out. The Panthers can’t rely on staying competitive with their running backs.

In the battle of Alabama QBs, Tagovailoa and Young will be at the forefront of a high-scoring contest in Week 6.

The Bet

Best NFL Week 6 Parlay

Interested in a Week 6 NFL Parlay? Well, we’ve got a great one for you. This five-leg football parlay has +1143 odds. 

On a $100 wager, bettors have the potential to win a whopping $1,143.13 and more than 10x their money for one parlay ticket:

  • Los Angeles Rams (-240)
  • New Orleans Saints (-140)
  • Seattle Seahawks (+125)
  • Minnesota Vikings (-160)
  • Philadelphia Eagles (-250)
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Kyle Eve
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Kyle Eve is a seasoned pro of The Sports Geek. Since joining the team in 2012, Kyle, has covered some of the biggest sporting events in the world. From the Super Bowl and World Series to March Madness, the NBA Finals, Kentucky Derby, and many more, Kyle has provided reliable analysis for millions of readers. After dedicating himself to hockey and football in high school, Kyle placed his first sports bet on his 18th birthday. Since then, he has spent his entire adult life devoting himself to becoming the best sports bettor and casino gambler possible. Kyle is from Windsor, ON, Canada

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