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Indianapolis Colts vs Los Angeles Rams Prediction

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A.I. Game Picks

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See the best bets that The Geek is favoring for today’s matchup.

Spread

For every pick our AI engine makes, it also assigns a score from 1-100 reflecting how “confident” we are each pick is likely to hit. The higher the score, the more confidence our AI models are that our picks are going to be winners.

Moneyline

For every pick our AI engine makes, it also assigns a score from 1-100 reflecting how “confident” we are each pick is likely to hit. The higher the score, the more confidence our AI models are that our picks are going to be winners.

Total

For every pick our AI engine makes, it also assigns a score from 1-100 reflecting how “confident” we are each pick is likely to hit. The higher the score, the more confidence our AI models are that our picks are going to be winners.

The Los Angeles Rams will beat the Indianapolis Colts. The Los Angeles Rams will cover the spread, and the total will go under.

Analyzing both teams through their operational metrics leads me to this confident conclusion. The Colts might appear dominant on the surface, averaging 34.3 points per game, but their passing efficiency at 71.8% is unsustainably high over the long haul. Furthermore, their ground game, while effective with 153.3 rushing yards, relies heavily on volume with over 33 attempts, which could become a liability against a Rams’ defense that excels at limiting explosive plays.

On the other hand, the Rams deliver a more balanced and calculated approach, averaging 24.3 points while maintaining a respectable 65.0% pass completion rate. Their 246.3 passing yards provide a solid foundation, complemented by a steady run game averaging 127 yards per game on 27 attempts. Key in this matchup will be the Rams’ ability to apply pressure, something they have excelled at lately. A consistent pass rush will disrupt the Colts’ rhythm, stalling drives and keeping their scoring in check. Given the defensive liabilities of the Colts and the Rams’ capability to control the tempo, I expect a lower-scoring affair that favors the Rams both in victory and with the total staying under.

User Consensus Picks

For every pick our AI engine makes, it also assigns a score from 1-100 reflecting how "confident" we are each pick is likely to hit. The higher the score, the more confidence our AI models are that our picks are going to be winners.

Here is the betting public’s consensus picks for the spread, moneyline, and total for today’s game. Log in with a free account and add your picks to the tally.

Spread Sep 28, 2025
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Moneyline Sep 28, 2025
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Total Sep 28, 2025

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