nfl

Jacksonville Jaguars vs San Francisco 49ers Prediction

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A.I. Game Picks

For every pick our AI engine makes, it also assigns a score from 1-100 reflecting how "confident" we are each pick is likely to hit. The higher the score, the more confidence our AI models are that our picks are going to be winners.

See the best bets that The Geek is favoring for today’s matchup.

Spread

For every pick our AI engine makes, it also assigns a score from 1-100 reflecting how “confident” we are each pick is likely to hit. The higher the score, the more confidence our AI models are that our picks are going to be winners.

Moneyline

For every pick our AI engine makes, it also assigns a score from 1-100 reflecting how “confident” we are each pick is likely to hit. The higher the score, the more confidence our AI models are that our picks are going to be winners.

Total

The San Francisco 49ers will beat the Jacksonville Jaguars. The San Francisco 49ers will cover the spread, and the total will go under.

The expected outcome is heavily influenced by the disparity in offensive efficiency. The 49ers score an average of 19.7 points per game, but their impressive 68.9% completion rate in the passing game indicates they execute plays effectively when passing. In contrast, the Jaguars may score higher at 23.3 points per game but their pass completion percentage of 56.1% suggests a less efficient air attack. This inefficiency could be amplified against a well-structured 49ers defense, which excels at minimizing yards per pass attempt and will likely pressure the Jacksonville quarterback into making mistakes.

On the ground, the Jaguars rely on a heavier rushing attack, averaging 141.7 yards per game. However, it is worth noting that the 49ers have solid run defense metrics which will likely stifle the Jaguars’ ground game. Additionally, with the Jaguars’ push towards the run, this will likely limit the overall number of plays, contributing to the total points remaining under. In conclusion, expecting a strong performance from the 49ers while containing the Jaguars’ productivity leads to a likely victory for San Francisco, with a score trend pointing towards an under on total points.

User Consensus Picks

For every pick our AI engine makes, it also assigns a score from 1-100 reflecting how "confident" we are each pick is likely to hit. The higher the score, the more confidence our AI models are that our picks are going to be winners.

Here is the betting public’s consensus picks for the spread, moneyline, and total for today’s game. Log in with a free account and add your picks to the tally.

Spread Sep 28, 2025
sf jax
Moneyline Sep 28, 2025
sf jax
Total Sep 28, 2025

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