2025 NFL Week 10 Betting Preview: Odds, Lines, and Best Bets

The NFL Week 10 odds and betting lines don’t feature a double-digit favorite, so we should see plenty of close matchups! There are half a dozen divisional games, too, which could shake up the standings and have a significant impact on the playoff picture.

Continue reading to see the current betting lines for Week 10. I dissect the latest odds for every game and highlight my best bets for every matchup.

2025 NFL Week 10 Odds and Betting Lines (Snapshot)

Check out the table below for the updated Week 10 NFL odds, provided by Bovada.

The Buffalo Bills are the biggest favorites in the Week 10 odds, with most games within a touchdown in the spread markets.

There are four teams on a bye, including:

• Cincinnati Bengals (3-6)
• Dallas Cowboys (3-5-1)
• Kansas City Chiefs (5-4)
• Tennessee Titans (1-8)

See the current odds and wager on your best bets at Bovada by going to Sports > Football > NFL > NFL Week 10.

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Las Vegas Raiders vs. Denver Broncos Preview: Odds, Betting Lines, Best Bets

Week 10 kicks off with an AFC West battle between the Raiders (2-6) and the Broncos (7-2). Denver has won six straight games and can tighten their hold on first place in the division with a win on Thursday Night Football.

The Broncos are 8-point favorites at home for this divisional game. Las Vegas, meanwhile, is available as a +375 underdog in this game.

Denver is 4-0 at home so far this season and has a +59 point differential through nine games. The Raiders, for comparison, are 1-3 on the road and have a -78 point differential this season.

Las Vegas has lost six of the last seven, including an OT loss last week at home to Jacksonville. On the bright side, Brock Bowers finally returned from injury, reeling in three TDs in his first action since Week 4.

Having Bowers back gives Geno Smith a reliable target, but the Raiders are all but punting on the season after trading away WR Jakobi Meyers. It is unlikely that Bowers can repeat his performance from last week, especially on short rest.

The Broncos’ defense, which leads the NFL with 40 sacks, should shut down the Raiders to earn Denver’s first divisional win of the season.

Atlanta Falcons vs. Indianapolis Colts Preview: Odds, Betting Lines, Best Bets

The Falcons and Colts must put their disappointing losses from Week 9 behind them as they prepare to square off in Berlin. Indianapolis is the designated home team, and the Colts are laying 5.5 points against Atlanta.

Indy’s 27-20 loss in Pittsburgh last week was just their second defeat of the season. The Colts turned the ball over six times, and Daniel Jones was sacked five times. Jonathan Taylor’s MVP campaign also took a hit, with the NFL’s leading rusher generating just 45 yards on 14 rush attempts.

Taylor should see more work this weekend against a Falcons’ defense that is one of the best in the league at stopping the pass. The Colts also traded for CB Sauce Gardner, and the former first-round pick should significantly improve Indy’s secondary.

Atlanta’s offense has the weapons to keep up with the Colts, but the Falcons have struggled to score consistently. The Colts should bounce back from their loss last week with an international win over the Falcons in Berlin. 

New Orleans Saints vs. Carolina Panthers Preview: Odds, Betting Lines, Best Bets

The Saints (1-8) are 5-point underdogs against the Panthers (5-4) in Carolina this week. Carolina is coming off a major upset win over the Packers on Sunday and has a 3-1 record at home this season.

New Orleans, conversely, is winless on the road and lost 34-10 last week in rookie Tyler Shough’s first career start. The Saints also traded WR Rashid Shaheed, one of their best offensive weapons, to Seattle on Tuesday. 

Without Shaheed, the Saints’ already lackluster offense, which has produced just 15.3 PPG, will be even worse. New Orleans’ defense could also be in trouble this week. The Saints allow 129.4 rushing YPG, ninth-most in the NFL.

Carolina, thanks in large part to the emergence of Rico Dowdle, is averaging 135.5 rushing YPG, fifth-most in the NFL. Chuba Hubbard also recently returned for the Panthers, giving Carolina one of the best two-headed rushing attacks in the NFL.

Dowdle and Hubbard should both have productive days in a big divisional win for the Panthers this week.

New York Giants vs. Chicago Bears Preview: Odds, Betting Lines, Best Bets

Two marquee franchises face off as the Giants head to the Windy City to take on the Bears. New York dropped to 2-7 last week after a 34-24 loss to the visiting 49ers. Chicago, on the other hand, improved to 5-3 with a 47-42 win over the Bengals in Cincinnati.

The Bears’ defense has allowed 72 points in the past two weeks. Despite that, Chicago are 3.5-point home favorites against the G-Men on Sunday.

New York’s best offensive skill players, Malik Naber and Cam Skattebo, are both out for the year. Rookie Jaxson Dart has played admirably with the remaining pieces around him, but the Giants’ offense has simply lost too many talented players to keep pace with the Bears this week.

Of course, the Bears have not been a perfect team this season, either. Their defensive struggles are especially concerning. Chicago should pick up the win at home, but the Bears’ recent defensive performances make it difficult to trust them to cover more than a field goal.

Jacksonville Jaguars vs. Houston Texans Preview: Odds, Betting Lines, Best Bets

An important game in the AFC South standings takes place this weekend as the Jaguars head to Houston to take on the Texans. The Jags picked up their fifth win of the season last week, taking down the Raiders in OT.

Houston wasn’t so lucky, falling 18-15 at home to the visiting Broncos. To make matters worse, Texans’ QB C.J. Stroud exited the loss with a concussion. Given the current NFL concussion protocols, there is a chance that Strough misses this week’s game.

Stroud’s health is a concern, but the Jaguars are far from a lock to win the game even if Houston is without its QB. The Texans’ defense has the lowest points allowed in the NFL, giving up just 15.1 PPG.

Houston also has a +47 point differential, despite being 3-5. Jacksonville, for comparison, is 5-3, but has an -8 point differential this season. This should be a defensive battle, and Houston has the better overall defense, so I’m happy to back them.

Buffalo Bills vs. Miami Dolphins Preview: Odds, Betting Lines, Best Bets

Another divisional matchup scheduled for Week 10 pits the Bills against the Dolphins in Miami. Buffalo won the first game of this divisional series, taking down the Dolphins 31-21 at Highmark Stadium.

Miami lost on TNF last week, dropping to 2-7 on the year. On the bright side, they will have extra time to prepare for this home game. Despite the rest, Miami are 9.5-point underdogs against the Bills on Sunday.

Buffalo has plenty of momentum after taking down the Chiefs last week. The Bills (6-2) also need to win this game to keep pace with New England (7-2) in the race to win the AFC East.

Buffalo should win, but covering a 9.5-point spread against a divisional opponent will be challenging. Miami did help the Bills by trading Jaelen Phillips to Philadelphia, weakening the Dolphins’ defense. Even without Phillips, I believe Miami will keep this game within single digits this time around.

Baltimore Ravens vs. Minnesota Vikings Preview: Odds, Betting Lines, Best Bets

Baltimore kept their playoff hopes alive and earned their first two-game winning streak of the season with their 28-6 win over the Dolphins last week. The Ravens will attempt to improve to 4-5 this week as they take on the Vikings (4-4) in Minnesota.

J.J. McCarthy returned to the Vikings’ lineup last week and led Minnesota to a major 27-24 upset win over the Lions in Detroit. The win was impressive, but Minnesota are 4-point underdogs at home this Sunday against Baltimore.

A key part of the Vikings’ success this year is their aggressive defense. Minnesota has 23 sacks this season and allows fewer than 200 passing YPG.

A stout passing defense could be a major problem for Baltimore. Derrick Henry has struggled to produce consistently this year, and Lamar Jackson only recently returned from a hamstring injury. If the Ravens cannot get their running game going, the Vikings have a great shot to pull off the upset in back-to-back weeks.

Cleveland Browns vs. New York Jets Preview: Odds, Betting Lines, Best Bets

The Jets, fresh off a bye and their first win of the season, opened as 2-point home favorites against the Browns this week. However, after trading CB Sauce Gardner and DT Quinnen Williams at the deadline, the Jets are now 2.5-point home underdogs.

Losing Williams could prove especially costly this week. Cleveland’s passing offense leaves a lot to be desired, but the Browns appear to have a future star in rookie running back Quinshon Judkins.

Judkins hurt his shoulder in Week 8, but the Browns’ bye week gave him time to recover. It also gave Cleveland’s defense extra time to prepare for the Jets. The Browns had six sacks in their loss to the Patriots, and they have 24 so far this season.

Myles Garrett and company should overwhelm the Jets’ offense, and New York’s defense will not be able to stop Judkins.

New England Patriots vs. Tampa Bay Buccaneers Preview: Odds, Betting Lines, Best Bets

A missed extra point late in the fourth quarter helped the Patriots secure a 24-23 win over the Falcons. It was New England’s sixth straight win. Now, the Pats will travel to Tampa Bay to take on the NFC South-leading Buccaneers.

Tampa Bay had a bye last week, and few teams needed the time off more than the Bucs. The extra time off gave them time to get healthy, and stars such as RB Bucky Irving are expected to return.

Baker Mayfield overcame the surrounding injuries to lead one of the most productive units in the NFL. Now that Tampa Bay is healthier, Mayfield should be even better.

Drake Maye and the Patriots have also been highly productive. Maye is fifth in passing yards (2,285) and has a 17:4 TD to INT ratio. However, the quarterback has also been sacked 34 times this season, the second most in the NFL.

Tampa Bay are eighth in the league with 25 sacks this season. A rested and motivated Bucs’ team can certainly end the Patriots’ winning streak on Sunday.

Arizona Cardinals vs. Seattle Seahawks Preview: Odds, Betting Lines, Best Bets

Jacoby Brissett led the Cardinals to an upset win over the Cowboys on Monday Night Football in Week 9. The win ended Arizona’s five-game losing streak and earned Brissett the starting QB job going forward.

Brissett and the Cards are 6.5-point underdogs this week in Seattle against the Seahawks. Seattle also won on the road in primetime last week, dominating the Commanders 38-14.

The Seahawks made a move ahead of Tuesday’s trade deadline, acquiring WR Rashid Shaheed from the Saints. The speedy receiver could make Seattle’s already potent offense even more efficient.

Arizona’s win over Dallas was a nice story, but there is a reason the team had lost its previous five games. The defense allows over 230 passing YPG and will struggle to contain Sam Darnold and the Seahawks. Seattle should win comfortably and maintain first place in the NFC West.

Los Angeles Rams vs. San Francisco 49ers Preview: Odds, Betting Lines, Best Bets

The other NFC West teams, the Rams and the 49ers, also square off this week. San Francisco won the first matchup, defeating Los Angeles 26-23 in OT at SoFi Stadium in Week 5.

Oddsmakers have the 49ers as 3.5-point home underdogs for the rematch this weekend. Since they last played, San Francisco has gone 2-2 and lost several starters to injury. LA, conversely, are undefeated since that TNF loss, outscoring opponents 86-20.

The winner of this game could take over control of the NFC West. San Fran’s Brock Purdy is questionable, but the offense has played better without him under center this season. If Purdy returns and is rusty, it could give LA the edge needed to even the regular-season series at 1-1.

LA is tied for third with 27 sacks so far this season. The Rams have also been among the most productive offenses, averaging 26.1 PPG this year. An LA team that is out for revenge will be too much for the injury-depleted 49ers to handle this time around.

Detroit Lions vs. Washington Commanders Preview: Odds, Betting Lines, Best Bets

The Lions and Commanders are two teams hoping to bounce back from losses this week. Detroit fell 27-24 at home to the rival Vikings.

Washington’s defeat was worse, losing 38-14 against the visiting Seahawks. Unfortunately for the Commanders, their biggest loss did not come on the scoreboard. Starting QB Jayden Daniels will miss most, if not all, of the remainder of the season with a dislocated left elbow.

With Daniels out, it comes as no surprise that the Commanders are 9-point home underdogs this Sunday.

Detroit has had their fair share of injuries, especially on defense. The Lions offense is at full strength, though, and is the second-highest scoring unit in the league at 29.9 PPG.

Washington allows 26.2 PPG, and that number is likely to go up as their injuries continue to mount. The Lions should win and cover against an injury-riddled Commanders team this weekend.

Pittsburgh Steelers vs. Los Angeles Chargers Preview: Odds, Betting Lines, Best Bets

The Steelers are back in primetime this week, heading to LA to face the Chargers. Pittsburgh (5-3) upset the Colts last week, but has the worst point differential of any division leader at +7.

Los Angeles (6-3) has a +22 point differential and is 5-1 against the AFC this season. They need a win to stay in second in the AFC West. The Chargers are field-goal home favorites on Sunday Night Football this week.

Pittsburgh won this matchup last year, taking down LA 20-10 in Week 3. The Steelers’ defense has been hit or miss this season, but they are coming off one of their best performances. Pittsburgh secured six turnovers and five sacks in a win over the Colts.

The Steelers’ defense has another chance to rack up stats this week against a Chargers’ team missing multiple starting offensive linemen. Harassing Justin Herbert early and often is the key to slowing down LA’s passing attack, which has the sixth-most passing YPG (250.6).

LA is also without rookie Omarion Hampton again this week, forcing the Chargers to lean on Kimani Vidal as their RB1 this weekend.

Vidal has been up-and-down as the Chargers’ top RB option, making LA a risky bet in this matchup. The Steelers’ defense, tied for third with 27 sacks, should overwhelm the Chargers’ depleted O-Line and lead Pittsburgh to another win.

Philadelphia Eagles vs. Green Bay Packers Preview: Odds, Betting Lines, Best Bets

The final game of Week 10 is a Wild Card rematch between the Eagles (6-2) and the Packers (5-2-1). Philadelphia was on a bye last week, allowing the Eagles extra time to prepare for this MNF matchup.

Green Bay is a 2.5-point favorite in this primetime matchup. The Packers need a win after falling 16-13 last week at home to the Panthers.

Philadelphia’s bye week gave it extra time to recover and prepare for an inconsistent Packers’ offense. The Eagles were also aggressive at the trade deadline, adding CB Jaire Alexander, DE Jaelen Phillips, and CB Michael Carter II.

Their defense was a big part of the Eagles’ title run last season. It is unclear how many snaps their new pieces will play this week, but Philly’s offense can use the blueprint provided by the Panthers to take down the Packers on MNF.

The Eagles’ offense has struggled at times this season, but the Packers’ issues on offense have been worse. Philly’s extra prep time and the motivation from an active trade deadline should lead the Eagles to a win.

Where to Find NFL Week 10 Odds and Betting Lines?

Bovada has the best lines for the NFL in Week 10. You can wager on moneyline, point spreads, point totals, and more for each of the 14 games on this week’s schedule.

New members who redeem the code BV1000 when making their first deposit can claim a 50% welcome bonus. This offer is worth up to $1,000 in extra funds that can be used to wager on your NFL Week 10 best bets.

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