2025 NFL Week 4 Betting Preview: Odds, Lines, and Best Bets

The NFL Week 4 odds and betting lines feature several must-see matchups, including a marquee game between the Chiefs and Ravens. There is also an international game, as the Vikings face the Steelers in Ireland.

This is the final week before byes, too, so it is your last chance to bet on all 32 teams for the foreseeable future. With that in mind, let’s explore the odds for every Week 4 NFL game, and my best bets for all matchups.

2025 NFL Week 4 Odds and Betting Lines (Snapshot)

Here are the latest Week 4 NFL odds, courtesy of BetUS Sportsbook.

Week 4 starts with an NFC West battle on Thursday Night Football between the Seahawks and the Cardinals. Then, Sunday’s games kick off at 9:30 am ET from Ireland. There are also two Monday Night Football games on the schedule this week.

Buffalo is the biggest favorite of the weekend by far at -17 points. The Bills won last week but failed to cover their 12-point spread against Miami. Josh Allen and company will have an even larger spread to cover this week against the lowly Saints.

You can find the latest Week 4 NFL odds and betting lines by going to BetUS and navigating to Sportsbook > Football > NFL > NFL Week 4.

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Seattle Seahawks vs. Arizona Cardinals Preview: Odds, Betting Lines, Best Bets

The Seahawks and Cardinals are both 2-1, with their only losses coming against fellow NFC West team, the San Francisco 49ers. Seattle and Arizona will square off on TNF for the right to remain in second place in the division.

Arizona is a 1-point home favorite, but this game is a pick’em on the moneyline. The over/under is set at 43 points at the top NFL betting sites.

Seattle has won back-to-back games, taking down the Steelers and the Saints. Arizona’s wins, on the other hand, came against New Orleans and the Panthers. Their common opponent, the Saints, is too weak a team to glean much from either team’s win.

The Seahawks’ win over Pittsburgh, on the other hand, was much more impressive than Arizona’s victory over Carolina. Seattle’s Kenneth Walker III has three rushing scores and 168 scrimmage yards in the last two weeks. If he continues to produce like that this week, he will help Seattle pick up a division win.

Minnesota Vikings vs. Pittsburgh Steelers Preview: Odds, Betting Lines, Best Bets

Sunday’s international game between the Vikings and Steelers starts at 9:30 am ET. Pittsburgh is the home team, but they are getting 2.5 points in Ireland. The Vikings are -145 moneyline favorites in this overseas cross-conference matchup. 

Pittsburgh struggled on both sides of the ball in the first two weeks, and the Steelers were lucky to start 1-1 despite a -12 point differential. The Steelers’ defense looked much better against New England, holding the Pats to 14 points and making multiple red zone stands.

Minnesota’s defense also played lights out in Week 3, forcing multiple turnovers and scoring twice in the 48-10 win over Cincinnati. Carson Wentz played well in his first start of the year, minimizing mistakes and throwing two TD passes.

The Steelers’ defense is better than Cincinnati’s, so Wentz will need to be at his best again this week. Minnesota’s defense is also unlikely to force Aaron Rodgers into the same mistakes that Jake Browning committed, so the Vikings cannot count on two scores from turnovers.

Despite that, I believe Minnesota will win and cover the spread on the road against Pittsburgh.  The Vikings are the better team overall, so I trust their chances in this one.

Washington Commanders vs. Atlanta Falcons Preview: Odds, Betting Lines, Best Bets

Washington survived Week 3 without Jayden Daniels, taking down the Raiders 41-24. Daniels missed last week with a knee injury, but he could be back this week. The Commanders are 1-point favorite on the road against the Falcons.

Atlanta could not find its footing on offense last week against Carolina. The Panthers had allowed 26.5 PPG the first two weeks, but they shut out the Falcons in Week 3.

Every team has bad games, and there is too much talent on the Falcons roster, especially on offense, for them to go scoreless again. Washington, on the other hand, is a risky bet if Marcus Mariota ends up starting again.

The quarterback completed 15 passes for 207 yards in the win. The Commanders were able to win despite Mariota’s slow day passing because the team accumulated 200+ rushing yards for the second time in three games this season.

Atlanta’s defense has been good against the run so far, but Washington will be the toughest test the Falcons have faced this season. In the end, the Commanders should pick up the road win and cover the 1-point spread.

New Orleans Saints vs. Buffalo Bills Preview: Odds, Betting Lines, Best Bets

The 3-0 Bills are a -1600 moneyline favorite this week at home against the Saints. At their current odds, Buffalo has a 94.12% implied win probability.

It would be shocking if the Bills lose to a Saints team that has allowed 30 PPG this season, but stranger things have happened. The better question is whether Josh Allen and company can cover the 17-point spread.

Buffalo fell just short of covering its 12-point spread last week, beating the Dolphins 31-21. They are 2-1 ATS this year, upsetting the Ravens in Week 1 and easily beating the Jets by 20 in Week 2.

The Saints were competitive in the first two weeks, but they were plain bad last week in their 44-13 loss against the Seahawks. A demoralizing loss like that can linger, and there is little to no reason not to expect the Saints to be blown out again this week. 

Cleveland Browns vs. Detroit Lions Preview: Odds, Betting Lines, Best Bets

Cleveland shocked the football world last week, coming back from down 10-0 with under four minutes left to beat the Packers. Now, the Browns face another tough NFC North team, the Lions. Detroit is a 9-point home favorite against Cleveland on Sunday.

The Lions took down Baltimore in Week 3 in one of the best games of the year so far. Detroit’s defense sacked Lamar Jackson seven times in the win. Running backs Jahmyr Gibbs and David Montgomery combined for 218 rushing yards and four scores.

Gibbs and Montgomery will have a tough time moving the ball against a stiff Browns’ run defense. Cleveland’s defense, which sacked Jordan Love five times, could also cause problems for Jared Goff.

The Browns would be a good bet to cover if this game were in Cleveland. They have allowed just 13.5 PPG in home games this year. Unfortunately for them, this game is in Detroit, so the Lions should win and cover the spread.

Tennessee Titans vs. Houston Texans Preview: Odds, Betting Lines, Best Bets

The Titans and the Texans will meet this week for the first of their two games this season. Both teams are 0-3, and whether they like it or not, one of them has to win this week. Houston is a -7-point favorite at home.

Tennessee’s defense has tried to keep the team competitive this season, forcing five total turnovers so far. Unfortunately, the offense has been able to hit the ground running with rookie Cam Ward at quarterback. The Titans are averaging 17 PPG this year, the fifth-fewest in the NFL.

Houston’s offense has been even worse, managing a league-low 12.7 PPG this year. The Texans have just 802 passing yards this year, which is the fourth-fewest. Tennessee, for reference, has the second-fewest with 667.

This should be a low-scoring game, and the Texans have done little to prove they deserve to be a touchdown favorite over anybody. Houston should win, but I don’t expect them to cover the spread.

Carolina Panthers vs. New England Patriots Preview: Odds, Betting Lines, Best Bets

The Panthers (1-2) picked up their first win of the season in dominant fashion, shutting out Atlanta 30-0. Carolina is a 6-point underdog this week against New England. The Patriots are also 1-2 and had ample chances to win last week but could not execute in plus territory.

Carolina was able to force three turnovers last week, including two picks. The Patriots, on the other hand, lost the turnover battle thanks in large part to their four combined fumbles.

Many of the Pats’ turnovers came in crucial moments of the game, with two occurring on Pittsburgh’s side of the field. If those issues continue this week, New England could be in serious trouble.

Mike Vrable is an experienced coach who should help his team address its turnover problems. New England will win this game to improve to 2-2 if Drake Maye can play like he did in Week 2. However, I would not bet on New England to cover the 6 points against the Panthers. 

Los Angeles Chargers vs. New York Giants Preview: Odds, Betting Lines, Best Bets

The Chargers’ 3-0 start has them sitting alone atop the AFC West division. All of their wins this season have come against divisional opponents, giving Los Angeles a 2.5-game lead over the rest of the West.

LA is a 6.5-point road favorite this week against the Giants. New York is 0-3 after falling to the Chiefs on Sunday Night Football.

The Giants also announced that they will be starting rookie quarterback Jaxson Dart. A talented but raw prospect, putting Dart under center could be a sign that Brian Daboll is coaching for his job.

Dart is likely to struggle against a Chargers defense that allows just 182 passing YPG. LA has also only allowed 16.7 PPG, which is the fourth-fewest in the NFL. The Chargers should win and cover, handing the Giants their second loss to an AFC West team in as many weeks.

Philadelphia Eagles vs. Tampa Bay Buccaneers Preview: Odds, Betting Lines, Best Bets

One of the biggest matchups of Week 4 pits the Eagles (3-0) against the Buccaneers (3-0) in Tampa Bay. As two of the three remaining undefeated teams in the conference, the winner of this game will have a major advantage in the race for the number one seed.

Tampa Bay have the home advantage, but they are getting 3.5 points for this matchup against the defending Super Bowl champions. The Bucs have a 4-1 record against the Eagles when Jalen Hurts is under center for Philadelphia.

They also beat the Eagles last year when they played in Tampa in Week 4. Unfortunately, the Bucs could be without two of their top receivers for this game. Chris Godwin is still working his way back from an ankle injury he suffered last year, while Mike Evans is out with a hamstring injury.

Even with the injuries, I think the Buccaneers are a good bet to secure the upset. Philly’s offense has struggled this year and would have cost the Eagles the win last week if not for a 19-point comeback and a blocked field goal.

Baker Mayfield has led three fourth-quarter game-winning drives in as many weeks this season. This has helped him rise as an MVP candidate this season, so the confidence is high in Tampa. They have been more consistent than the champs, and I expect more of the same.

Indianapolis Colts vs. Los Angeles Rams Preview: Odds, Betting Lines, Best Bets

Speaking of undefeated teams, the Colts put their 3-0 record on the line against the Rams (2-1) in LA this week. LA was on the wrong side of Philly’s game-sealing field goal block last week. The Rams are 3.5-point favorites against Daniel Jones and the Colts in Week 4.

Prior to the Eagles’ comeback, the Rams were up 26-7 in the fourth quarter. However, they then allowed 26 unanswered points to end the game, including a 61-yard return on a blocked field goal.

The Colts, on the other hand, have been arguably the most surprising team of the 2025 season. Indy’s 418.7 offensive YPG are second only to the Bills so far this season. Also, Jones has yet to throw an interception.

Indy’s 460 rushing yards are the third-most in the league, and they have six rushing touchdowns. The Colts’ 34.4 PPG is tied for the second-most this season. Jones will turn back into his old self eventually, but he should have enough left in the tank to beat a Rams team that is still reeling from its shocking loss last week.

Jacksonville Jaguars vs. San Francisco 49ers Preview: Odds, Betting Lines, Best Bets

Jacksonville improved to 2-1 with its win over Houston last week. San Francisco also won last week, improving to 3-0 on the season and picking up its second win with Mac Jones at quarterback. The Jags face the 49ers this week, and San Fran is a 3-point home favorite.

Jones played well enough to win his starts, but he was injured last week. On the bright side, the 49ers could be getting Brock Purdy back under center this week. If Jones and Purdy are both out, though, then the 49ers are in serious trouble.

The 49ers’ injury woes do not stop at the QB position, either. Pro Bowl and All-Pro pass rusher Nick Bosa tore his ACL last week, knocking him out for the season. San Fran is also dealing with multiple injuries to its offensive skill players.

Jacksonville’s roster, conversely, is relatively healthy. However, the Jags have struggled over the last two weeks, including a loss to a Bengals team that relied on Jake Browning at QB for most of the game. The 49ers have a healthy Christian McCaffrey, and that will be enough to power them to a win this week.

Baltimore Ravens vs. Kansas City Chiefs Preview: Odds, Betting Lines, Best Bets

For the second time this season, the Chiefs are an underdog at home. Kansas City picked up their first win of the season last week, beating the Giants on SNF. Now, Patrick Mahomes and KC are getting 2.5 points against the Ravens.

Baltimore is also 1-2, with a dominant win over Cleveland sandwiched between tough losses to the Bills and Lions. To make matters worse, Derrick Henry has fumbled at least once in every game this year, including twice in the fourth quarter of games.

Henry’s fumbling issues aside, the Ravens have been the best offense in football. They have the most points scored (111) and the best PPG average (37) through three games. Lamar Jackson also leads the league with nine touchdown passes this season.

History is against the Ravens this week at Arrowhead. Including the playoffs, Lamar is just 1-5 against Mahomes in their careers. The value is on KC, as both teams have struggles to get enough wins so far.

Chicago Bears vs. Las Vegas Raiders Preview: Odds, Betting Lines, Best Bets

Chicago (1-2) dominated Dallas in Week 3, taking down the Cowboys 31-14 at home. Now, the Bears will travel to Las Vegas to face the Raiders (1-2), with both teams looking to improve to .500 this season.

The Raiders are a 1-point home favorite, and the moneyline is listed as a pick’em in this cross-conference matchup.

Las Vegas has plenty of young skill players, but they have struggled to get them involved this season. A big reason for the Raiders’ issues is their offensive line. Rookie running back Ashton Jeanty has more yards after contact (145) than total rushing yards (144) this season.

In other words, the Raiders are not doing a good enough job blocking for Jeanty. That could change this week, as the Bears have allowed 418 rushing yards, sixth-most in the league through three games.

Even if Jeanty gets rolling, the Raiders have no answer for Rome Odunze and Luther Burden III. Assuming Caleb Williams continues to improve this week, the Bears’ passing attack should overpower the Raiders.

Green Bay Packers vs. Dallas Cowboys Preview: Odds, Betting Lines, Best Bets

Many fans across the country circled this Week 4 SNF matchup when Dallas traded star pass rusher Micah Parsons to Green Bay on the eve of the regular season. Parsons and the Packers are 7-point favorites against the Cowboys.

Green Bay is coming off an embarrassing loss to Cleveland. The Packers allowed 13 unanswered points in the final four minutes of their 13-10 loss to the previously winless Browns.

The good news is the Packers now have a chance to work out their frustrations against the Cowboys. Dallas is 1-2 this season and lost by 17 points last week against Chicago. The Cowboys’ defense is the perfect opponent for Green Bay, which is trying to work out issues with its injury-hampered passing attack.

Dallas will be without CeeDee Lamb as the receiver nurses an ankle injury. Lamb’s absence will make it even more challenging to move the ball against a Packers’ defense that has only allowed 232.3 YPG to opposing offenses. Green Bay should win, but covering 7 points away from home will be hard.

New York Jets vs. Miami Dolphins Preview: Odds, Betting Lines, Best Bets

In the first of two MNF games this week, the Jets (0-3) take on the Dolphins (0-3) in Miami. Neither team has a win this season, and the loser of this game will be alone at the bottom of the AFC East and have the worst record in the NFL.

Miami is listed at -3 as a home favorite for this contest. New York is available at +134 on the moneyline.

The Jets nearly upset the Buccaneers last week after scoring three fourth-quarter touchdowns and taking a 27-26 lead with under two minutes to go. However, they could not hold the lead, and the Buccaneers won on a walk-off field goal.

New York’s starting QB for this game is up in the air as Justin Fields works his way back from a concussion he suffered in Week 2. If Fields is out, the Jets’ rushing attack will suffer, but their passing attack could improve.

Miami’s passing offense also looked better last week, but they were not able to beat the Bills. If they can repeat their performance from TNF, though, the Dolphins should get their first win of the year this week.

Cincinnati Bengals vs. Denver Broncos Preview: Odds, Betting Lines, Best Bets

The final game of Week 4 pits the Bengals (2-1) against the Broncos (1-2) in Denver. Jake Browning and the Cincinnati is a 7-point underdog for this matchup. The Broncos are -375 moneyline favorites at home.

Denver won at home in Week 1, but their offensive issues cost the Broncos on their two-game road trip. Their defense is good enough to create similar havoc for the Bengals as Minnesota did last week.

Browning led Cincy to a win in Week 2, but the magic ran out last week. He threw two interceptions, and the Bengals turned the ball over five times.

I think Browning’s struggles will continue this week in Denver, while the Broncos have their own issues on offense. Denver should win, but it should be closer than the betting lines suggest.

Where to Find NFL Week 4 Odds and Betting Lines?

BetUS Sportsbook is the best place NFL Week 4 betting odds and lines because of the low juice and excellent variety of markets. The site has exciting and competitive lines for every game on this week’s schedule. It also features a great UI, making it easy to find odds on your favorite teams.

New members of BetUS can use the site’s 125% welcome bonus to get up to $2,625 on your three deposits.

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