Super Bowl 60 Betting Odds and Predictions: Can the Bills Finally Deliver?

Kansas City Chiefs (+600)

• • Head Coach: Andy Reid
  • 2024-25 Record: 15-2 (AFC)
  • Super Bowl Titles: 4
  • Key Players: Patrick Mahomes (QB), Travis Kelce (TE), Rashee Rice (WR), Nick Bolton (LB), Trent McDuffie (CB)

Love them or hate them, the Kansas City Chiefs are back in the mix as Super Bowl contenders. Although oddsmakers aren’t all convinced that the Chiefs should be clear favorites, they’re one of the most respected teams in the league.

It’s been an up and down season for the Chiefs, as they haven’t looked like a dynasty and vulnerable at times. They carry a record of 5-4 into Week 11 off their bye week and remain third in the standings, trailing the Los Angeles Chargers and Denver Broncos in the AFC West. In any event, it isn’t wise to discard the Chiefs with Patrick Mahomes under center.

Check out a complete updated run down of the offense and defense in Kansas City:

Offense

The Chiefs’ offense will remain a dangerous unit as long as Mahomes is at the controls. There isn’t a defensive coordinator that sees the Chiefs on the schedule and doesn’t get a headache or two.

Prior to the 28-21 Week 9 loss to the Buffalo Bills, Mahomes was favored to win his third regular season MVP award. He had a rough showing in Orchard Park, but Mahomes’ numbers are still in solid order.

Through nine games, Mahomes has passed for 2,349 yards, 17 touchdowns, and five interceptions on 64.6% completions. He has one of his favorite targets back on the field, as WR Rashee Rice returned to the field following a suspension. Rice’s presence allows TE Travis Kelce to find more room in the secondary.

Patrick Mahomes becomes the youngest QB in NFL history with 250 TD PASSES 🤯 pic.twitter.com/47ebLlpkv6

— Bleacher Report (@BleacherReport) September 28, 2025

Overall, the Chiefs are ninth, with an average of 26.1 points and seventh with 370.1 yards per game in the NFL. They could probably benefit from one more weapon, including an elite running back, but there aren’t any excuses. The offensive line hasn’t been perfect, either, as Mahomes has been sacked an average of two times per game.

If Mahomes stays healthy, the Chiefs’ offense is going to stay in business, though.

Defense

The Chiefs won three Super Bowls since 2020 not only because of Mahomes, but a physical defense that made plays at the right time. It’s tough to get a read on the Chiefs’ defense in 2025-26, though.

They can look elite one week and a complete dumpster fire that can’t get off the field on third down the next. The Chargers, Jaguars, and Bills didn’t have issues consistently moving the ball. Trevor Lawrence and the Jaguars scored 31 points on this team.

Josh Allen can't escape on 3rd down as the @Chiefs defense gets the stop.

KCvsBUF on CBS/Paramount+https://t.co/HkKw7uXVnt pic.twitter.com/AL7ElAj7Cp

— NFL (@NFL) November 3, 2025

In their biggest game of the year, the Chiefs’ defense couldn’t get a stop when it mattered the most against Josh Allen. It was already too late by the time they generated a pass rush in the fourth quarter.

Nevertheless, strong performances versus the Ravens and Lions offer plenty of optimism for another championship in Kansas City. With 5.4 yards allowed per play, the Chiefs are in the middle of the pack.

The Chiefs have allowed 291.8 yards per game, for sixth in the league. It would help greatly if the Chiefs could sustain a constant pass rush, but 2.2 sacks per game sits 17th this season. It’s all or nothing with this defense. The 2023 defense was certainly stronger than the current roster.

Los Angeles Rams (+625)

• Head Coach: Sean McVay
• 2024-25 Record: 10-7 (NFC West Champs)
• Super Bowl Titles: 2
• Key Players: Matthew Stafford (QB), Puka Nacua (WR), Davante Adams (WR), Byron Young (LB), Nate Landman (LB)

As Matthew Stafford excels in his 17th NFL season, the Los Angeles Rams have emerged as top Super Bowl contenders. After an impressive 42-26 Week 10 victory, the Rams are tied with the Seattle Seahawks for the NFC West lead at 7-2.

The Rams captured the Super Bowl title in 2022 and hope to replicate that achievement after finishing 10-7 in each of the past two seasons. Last year, they narrowly lost to Stafford’s former team, the Detroit Lions, 24-23 in a thrilling Wild Card Round matchup at Ford Field.

While the Rams may not receive as much media attention as the Chiefs or Eagles, their roster is well-built and has improved since last season. Here’s what makes the Rams such a dangerous team:

Offense

The Rams’ offense is led by Stafford’s outstanding performance this season. Although he has had some fantastic years in the NFL, Stafford is currently on pace for his best yet.

The 37-year-old quarterback has passed for 2,427 yards, 25 touchdowns, and just two interceptions with a 67.1% completion rate. His 114.8 QB rating ranks among the best in the league this season. Since Week 4, he’s thrown 20 touchdowns and no interceptions, making him a leading candidate for his first NFL MVP award.

Matthew Stafford: the OG of the no look pass 👀 pic.twitter.com/1Zb1NzbgSJ

— FOX Sports: NFL (@NFLonFOX) November 10, 2025

He benefits from a strong supporting cast on offense. WR Puka Nacua is excelling in his third NFL season and taking advantage of playing alongside WR Davante Adams. Together, Nacua and Adams form a dynamic duo in the passing game.

Nacua has 66 receptions for 775 yards and four touchdowns, all coming in four of the last five games. Adams, ecstatic to be in Los Angeles after difficult stints in Las Vegas and New York, has already notched nine touchdowns and 568 receiving yards on 42 receptions.

The Rams’ backfield is also formidable, featuring running backs Kyren Williams and Blake Corum. Williams leads the team with 659 yards and five touchdowns, averaging 4.5 yards per carry. Overall, the Rams rank fifth in the league with 373.3 yards and 27.9 points per game.

Defense

The Rams’ defense has developed into a top-tier unit over the past year, making significant strides and entering elite territory this season. Under Sean McVay, they’ve held opponents to just 17 points per game, ranking second in the NFL, trailing only the Houston Texans in points allowed during the 2025-26 campaign.

Running against the Rams has proven difficult, and their secondary consistently makes impactful plays. Through nine games, they’ve allowed only 96.9 rushing yards and 216 passing yards per outing.

LB Byron Young has been a major disruptor, tallying 45 tackles and already surpassing last season’s career-high with nine sacks. Alongside leading tackler Nate Landman and pass rusher Jared Verse, the Rams boast a tough, well-rounded defense.

“You can’t find many bad snaps on tape with him.”

🎙️DC Chris Shula on OLB Byron Young pic.twitter.com/ix8NqmHTJk

— Los Angeles Rams (@RamsNFL) September 18, 2025

While Matthew Stafford’s MVP-caliber season has drawn much of the spotlight, don’t overlook the Rams’ defense. Their potent unit could provide a decisive edge in a low-scoring, physical playoff game.

If you’re deciding between betting on the Chiefs or Rams, the defensive strength makes the Rams a compelling pick for your Super Bowl 60 predictions!

Philadelphia Eagles (+800)

• • Head Coach: Nick Sirianni
  • 2024-25 Record: 14-3 (Super Bowl Champs)
  • Super Bowl Titles: 2 (2025, 2018)
  • Key Players: Jalen Hurts (QB), A.J. Brown (WR), Saquon Barkley (RB), Jalen Carter (DL), Zack Baun (LB)

The Eagles captured their second Super Bowl in franchise history with a 40-22 win over the Chiefs. They wanted it more than the Chiefs and were rewarded for it in a blowout victory. It’s crazy to think that fans were calling for Sirianni’s head earlier in the season, and he exited the year hoisting the Vince Lombardi Trophy.

Although the latest Super Bowl 60 odds don’t have the Eagles at the top, they’re in a good position following a 10-7 win over the Green Bay Packers in a tough atmosphere at Lambeau Field. Earlier in the season, there was noise in the locker room with some unhappy players, but that has been squashed.

The latest Super Bowl odds have pushed the Eagles outside of the top spot, but they are keeping pace with the Bills at 6-2 on the season. There has been some noise for the Eagles to quell in the locker room, which they’ve done a fine job navigating.

Check out our review of the Eagles roster in 2025-26 and then continue reading below for Super Bowl 60 predictions to see if they’re the top pick!

Offense

After winning the Super Bowl last season, the Eagles have the core together offensively. QB Jalen Hurts is back on the field alongside WR A.J. Brown and WR DeVonta Smith. There was plenty of speculation leading up to the trade deadline that Brown would be on the move, though he will stay in Philadelphia.

Brown, and Smith to a lesser degree, reportedly weren’t too enthused with their role on the team earlier in the season. The news led to Brown trade rumors, but the trade deadline has passed with no changes to the offense.

Brown has been getting involved much more and putting up big numbers as of late, so I don’t expect any more negative reports.

Jalen Hurts' 79-yard TD pass to DeVonta Smith traveled 54.6 yards in the air, his 2nd deep TD pass of the game and 4th this season.

Only Baker Mayfield (7) has thrown more deep TD passes than Hurts (tied w/Stafford & Maye, 4).#PHIvsMIN | #FlyEaglesFlypic.twitter.com/vhD7MR8aNp

— Next Gen Stats (@NextGenStats) October 19, 2025

Hurts has been a dark horse MVP candidate this season, as the Eagles’ QB has passed for 1,860 yards, 16 touchdowns, and one interception on 68.9% completions. It’s tough to rule him out of the fight this early in the season. I expect the offense to click more down the stretch after solid performances versus the Giants, Vikings, and also came through in the clutch at Lambeau.

The Eagles’ offense is only 23rd, with 303.2 yards per game. However, they’ve scored a respectable 24.2 points per game for 12th in the league. The offense has been in better form recently, so I don’t think the numbers tell the whole story. Expect them to hit their full stride at the right time as the playoffs approach.

Defense

The Eagles went through a bit of roster turnover in the offseason. They said goodbye to several key cogs that were integral to the Eagles’ success. DE Josh Sweat departed for Arizona, while DE Brandon Graham called it a career and retired. That being said, Graham did a reversal and made his return to the Eagles recently to afford them a big locker room presence and leader on the field.

Additionally, DE Bryce Huff was traded to the 49ers in the offseason. That has left several holes to patch up, but defensive coordinator Vic Fangio has done a solid job against some of the best offenses in the NFL thus far. They’ve beaten Patrick Mahomes, Dak Prescott, Matthew Stafford, and Baker Mayfield.

Through nine matchups, the Eagles are 10th, with an average of 21.3 points allowed per game. While that doesn’t jump off the page, they’ve had a difficult schedule. Despite games against tough offenses, the Eagles are holding their own. CB Cooper DeJean has been a fantastic tackler, and LB Zack Baun is all over the field, delivering one interception and three sacks.

The Eagles’ defensive performance against the Packers on the road was a glimpse into what they are capable of when they’re in a rhythm. They held Packers’ QB Jordan Love to 176 yards and RB Josh Jacobs to 76 yards in a 10-7 win.

Zack Baun picks off Stafford to start the game!

LARvsPHI on FOX/FOX Onehttps://t.co/HkKw7uXVnt pic.twitter.com/SRD4nYqHUK

— NFL (@NFL) September 21, 2025

Like the offense, I don’t think the defense has reached its potential yet this season, either. They miss their pass rush from last season, but swung a deal to improve at the trade deadline. Acquiring LB Jaelan Phillips was a big addition to the defense.

Phillips’ presence will be notable on the Eagles, as he brings over three sacks and 25 tackles over with him from Miami. With the move, the Eagles’ defensive stock is up, and now Graham’s comeback gives the defense more flexibility and depth.